Endocrine-disrupting chemicals and skin manifestations
Abstract
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin. In addition, their effects on keratinocytes, melanocytes, sebocytes, inflammatory and immunological cells, and skin stem cells produce inflammatory and allergic skin diseases, chloracne, disorders of skin pigmentation, skin cancer, and skin aging. Mechanisms, which EDCs use to induce these skin disorders are complicated, and involve the interference of endogenous hormones and most importantly the activation of the aryl hydrocarbon receptor signal pathway. Further studies on EDCs and skin diseases are necessary to elucidate these mechanisms.
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By analyzing genetic responses to cosmetic ingredients, researchers can gain insights into potential long-term health impacts and identify ingredients that may disrupt normal cellular functions.
“By analyzing the genetic responses to various ingredients, researchers can gain insights into potential long-term health impacts and identify ingredients that may disrupt normal cellular functions (125).”
From The dark side of beauty: an in-depth analysis of the health hazards and toxicological impact of synthetic cosmetics and personal care products (2024) · cites this paper as [125]
Toxicogenomics examines how cosmetic ingredients affect gene expression and molecular pathways within the body.
“Toxicogenomics is yet another technique making strides in the cosmetic safety assessment. It examines how cosmetic ingredients affect gene expression and molecular pathways within the body.”
From The dark side of beauty: an in-depth analysis of the health hazards and toxicological impact of synthetic cosmetics and personal care products (2024) · cites this paper as [125]
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- Authors
- Ju, Q., & Zouboulis, C. C.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Städtisches Klinikum Dessau (DE)
- Corresponding author
- Zouboulis, Christos C.
- Venue
- Reviews in Endocrine and Metabolic Disorders
- Published
- 2016-06-30
- Volume
- 17
- Issue
- 3
- Pages
- 449-457
- ISSN
- 1389-9155 (ISSN-L)
- 1573-2606
- OpenAlex
- W2469333388
- Cited by
- 43
- References
- 7
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reviews in Endocrine and Metabolic Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81472894)
- Shanghai health system excellent academic leader training project (XBR2013113)
- Shanghai Municipal Health Bureau Key Project (20134037)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- endocrine disruptors, skin diseases, aryl hydrocarbon receptor, keratinocytes, melanocytes, sebocytes, skin stem cells, allergic skin diseases, chloracne, skin pigmentation disorders, skin cancer, skin aging, immunotoxicity, hepatotoxicity, carcinogenicity
- MeSH terms
- Environmental Exposure, Humans, Skin Diseases, Signal Transduction, Receptors, Aryl Hydrocarbon, Endocrine Disruptors
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