Clinical aspects and molecular diagnostics of skin aging

Zouboulis, Christos C.; Makrantonaki, Evgenia

doi:10.1016/j.clindermatol.2010.07.001

Cited by 341Skin Protection and AgingGenetics, Aging, and Longevity in Model OrganismsSkin and Cellular Biology Research

Clinical aspects and molecular diagnostics of skin aging

Zouboulis, Christos C., Makrantonaki, Evgenia·2011·Clinics in Dermatology

DOI 10.1016/j.clindermatol.2010.07.001

Open this paper in CoChat — free account

Abstract

This contribution will address the effect of aging on skin functions, with a particular focus on skin permeability, wound healing, angiogenesis, lipogenesis, sweat production, immune function, and vitamin D synthesis. With accelerating age, skin functions deteriorate due to structural and morphologic changes. Skin is prone to the development of several diseases, varying from benign to malignant. Because the number of persons aged 80 and older is expected to rise in the next decades, disease prevention will become an important issue. Screening examinations and prevention through public education starting at an early age regarding sun avoidance, the use of sunscreens and the importance of a balanced nutrition are the first steps for successful healthy aging. Although the fundamental mechanisms in the pathogenesis of aged skin are still poorly understood, a growing body of evidence points toward the involvement of multiple pathways. Recent data obtained by expression profiling studies and studies of progeroid syndromes illustrate that among the most important biologic processes involved in skin aging are alterations in DNA repair and stability, mitochondrial function, cell cycle and apoptosis, extracellular matrix, lipid synthesis, ubiquitin-induced proteolysis and cellular metabolism. Among others, a major factor that has been implicated in the initiation of aging is the physiologic decline of hormones occurring with age. However, hormones at age-specific levels may regulate not only age-associated mechanisms but also tumor suppressor pathways that influence carcinogenesis. Understanding the molecular mechanisms of aging may open new strategies to deal with the various diseases accompanying high age, including cancer.

Integrity signals

Registry

Crossref · 10.1016/j.clindermatol.2010.07.001

Cites

147 of 147 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Oxidative stress plays an important role in skin aging and skin damage, with its main feature being increased intracellular ROS.
“Oxidative stress plays an important role in skin aging and skin damage processes, and its main feature is increased intracellular ROS.”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [31]
Accumulation of ROS causes DNA damage, induces skin inflammatory response, reduces antioxidant enzymes, activates NF-kB and AP-1 to inhibit collagen production, and increases matrix metalloproteinases to decompose collagen and binding proteins in the dermis, eventually leading to skin aging.
“The accumulation of ROS causes DNA damage, induces skin inflammatory response, reduces antioxidant enzymes, activates nuclear factor kappa B (NF-kB) and activator protein1 (AP–1) to inhibit collagen production, and increases matrix metalloproteinases to decompose collagen and binding proteins in the dermis, which eventually leads to skin aging [30,31,32,33].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [31]

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
The limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200 · see citing works
Mechanisms of photoaging and chronological skin aging
Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., & Voorhees, J. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1462 · Cited by 1,849 · see citing works
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E. M., Zon, L. I., Kyriakis, J. M., et al. (1996) · Nature · doi:10.1038/380075a0 · Cited by 1,767 · see citing works
Positional Cloning of the Werner's Syndrome Gene
Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705 · see citing works
A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works
Gene expression profile of aging and its retardation by caloric restriction
Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473 · see citing works
Aging decreases the capacity of human skin to produce vitamin D3.
MacLaughlin, J. A., & Holick, M. F. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112134 · Cited by 1,442 · see citing works
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., & Smith, J. R. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1063 · Cited by 1,351 · see citing works
Genetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works
Association between premature mortality and hypopituitarism
Tomlinson, J., Holden, N., Hills, R., Wheatley, K., Clayton, R., Bates, A., Sheppard, M., & Stewart, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04006-x · Cited by 1,006 · see citing works
FOXO3A genotype is strongly associated with human longevity
Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983 · see citing works
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911 · see citing works
Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review
Carroll, P. V., Christ the members of Growth Hormon, E. R., Bengtsson, B. Å., Carlsson, L., Christiansen, J. S., Clemmons, D., Hintz, R., Ho, K., Laron, Z., Sizonenko, P., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4594 · Cited by 822 · see citing works
Resveratrol: A review of preclinical studies for human cancer prevention
Athar, M., Back, J. H., Tang, X., KIM, K., Kopelovich, L., Bickers, D. R., & Kim, A. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2006.12.025 · Cited by 733 · see citing works
Wound Fluid from Chronic Leg Ulcers Contains Elevated Levels of Metalloproteinases MMP-2 and MMP-9
Wysocki, A. B., Staiano-Coico, L., & Grinnell, F. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12359590 · Cited by 732 · see citing works
Aging-Dependent Large Accumulation of Point Mutations in the Human mtDNA Control Region for Replication
Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., & Attardi, G. M. (1999) · Science · doi:10.1126/science.286.5440.774 · Cited by 725 · see citing works
Microarrays and toxicology: The advent of toxicogenomics
Nuwaysir, E. F., Bittner, M. L., Trent, J. M., Barrett, J. C., & Afshari, C. A. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199903)24:3 · Cited by 656 · see citing works
Mitotic Misregulation and Human Aging
Ly, D. H., Lockhart, D. J., Lerner, R. A., & Schultz, P. G. (2000) · Science · doi:10.1126/science.287.5462.2486 · Cited by 599 · see citing works
Association of <i>FOXO3A</i> variation with human longevity confirmed in German centenarians
Flachsbart, F., Caliebe, A., Kleindorp, R., Blanché, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S., & Nebel, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809594106 · Cited by 572 · see citing works
The relationship between in vitro cellular aging and in vivo human age.
Schneider, E. L., & Mitsui, Y. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3584 · Cited by 569 · see citing works
Molecular mechanisms of skin ageing
Jenkins, G. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00425-0 · Cited by 559 · see citing works
Aging and Genome Maintenance: Lessons from the Mouse?
Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553 · see citing works
Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547 · see citing works
Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila
Rogina, B., Reenan, R. A., Nilsen, S. P., & Helfand, S. L. (2000) · Science · doi:10.1126/science.290.5499.2137 · Cited by 506 · see citing works
The quest for genetic determinants of human longevity: challenges and insights
Christensen, K., Johnson, T. E., & Vaupel, J. W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1871 · Cited by 489 · see citing works
Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts
Seshadri, T., & Campisi, J. (1990) · Science · doi:10.1126/science.2104680 · Cited by 477 · see citing works
Matrix metalloproteinase inhibition by green tea catechins
Demeule, M., Brossard, M., Pagé, M., Gingras, D., & Béliveau, R. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00009-1 · Cited by 429 · see citing works
Sexual hormones in human skin
Zouboulis, C., Chen, W.-C., Thornton, M., Qin, K., & Rosenfield, R. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-961807 · Cited by 379 · see citing works
Gene expression profile of aging in human muscle
Welle, S. L., Brooks, A. I., Delehanty, J. M., Needler, N. A., & Thornton, C. A. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00049.2003 · Cited by 355 · see citing works
UV photoprotection by combination topical antioxidants vitamin C and vitamin E
Lin, J.-Y., Selim, M. A., Shea, C. R., Grichnik, J. M., Omar, M. M., Monteiro-Riviere, N. A., & Pinnell, S. R. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.425 · Cited by 354 · see citing works
A Transcriptional Profile of Aging in the Human Kidney
Rodwell, G. E. J., Sonu, R., Zahn, J. M., Lund, J., Wilhelmy, J., Wang, L., Xiao, W., Mindrinos, M., Crane, E., Segal, E., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020427 · Cited by 338 · see citing works
Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans
Stahl, W., Heinrich, U., Jungmann, H., Sies, H., & Tronnier, H. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.3.795 · Cited by 317 · see citing works
Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin
Lavker, R. M., Gerberick, G. F., Veres, D., Irwin, C. J., & Kaidbey, K. H. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)90184-1 · Cited by 313 · see citing works
Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts.
Hara, E., Yamaguchi, T., Nojima, H., Ide, T., Campisi, J., Okayama, H., & Oda, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42146-6 · Cited by 311 · see citing works
Contoversies in Experimental Dermatology
Chuong, C., Nickoloff, B. J., Elias, P. M., Goldsmith, L. A., Macher, E., Maderson, P. A., Sundberg, J. P., Tagami, H., Plonka, P. M., Thestrup-Pederson, K., et al. (2002) · Experimental Dermatology · doi:10.1034/j.1600-0625.2002.00112.x · Cited by 288 · see citing works
Molecular Mechanisms of Skin Aging
Makrantonaki, E., & Zouboulis, C. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.027 · Cited by 288 · see citing works
Tissue Inhibitor of Metalloproteinases-1 Is Decreased and Activated Gelatinases Are Increased in Chronic Wounds
Bullen, E. C., Longaker, M. T., Updike, D. L., Benton, R. L., Ladin, D. A., Hou, Z., & Howard, E. W. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12612786 · Cited by 271 · see citing works
Skin antioxidants: Their role in aging and in oxidative stress — New approaches for their evaluation
Kohen, R. (1999) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(99)80087-0 · Cited by 260 · see citing works
Vitamin D Induces the Antimicrobial Protein hCAP18 in Human Skin
Weber, G., Heilborn, J. D., Chamorro, C. I., Hammarsjö, A., Törmä, H., & Ståhle, M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23687.x · Cited by 251 · see citing works
Degradation of Fibronectin and Vitronectin and Vitronectin in Chronic Wound Fluid: Analysis by Cell Blotting, Immunoblotting, and Cell Adhesion Assays
Grinnell, F., Ho, C.-H., & Wysocki, A. B. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12499839 · Cited by 244 · see citing works
Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity
West, M. D., Pereira‐Smith, O. M., & Smith, J. R. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90372-8 · Cited by 242 · see citing works
Reduced Expression of Connective Tissue Growth Factor (CTGF/CCN2) Mediates Collagen Loss in Chronologically Aged Human Skin
Quan, T., Shao, Y., He, T., Voorhees, J. J., & Fisher, G. J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.224 · Cited by 239 · see citing works
Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts
Millis, A. J. T., Hoyle, M., McCue, H. M., & Martini, H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90286-h · Cited by 239 · see citing works
Green tea polyphenol (−)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress
Katiyar, S. K., & Mukhtar, H. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.5.719 · Cited by 234 · see citing works
Chronological ageing and photoageing of the human sebaceous gland
Zouboulis, C. C., & Boschnakow, A. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00894.x · Cited by 226 · see citing works
Biochemistry of the Elastic Fibers in Normal Connective Tissues and its Alterations in Diseases
Uitto, J. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12530093 · Cited by 220 · see citing works
The Aged Epidermal Permeability Barrier
Elias, P. M., & Ghadially, R. (2002) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(03)00037-5 · Cited by 217 · see citing works
Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair
Katiyar, S., Elmets, C. A., & Katiyar, S. K. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.08.004 · Cited by 212 · see citing works
Update on photoprotection
Palm, M. D., & O'Donoghue, M. N. (2007) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2007.00150.x · Cited by 210 · see citing works
The role of telomeres in skin aging/photoaging
Kosmadaki, M., & Gilchrest, B. A. (2003) · Micron · doi:10.1016/j.micron.2003.11.002 · Cited by 198 · see citing works
Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (−)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production
Katiyar, S. K., Challa, A., McCormick, T. S., Cooper, K. D., & Mukhtar, H. (1999) · Carcinogenesis · doi:10.1093/carcin/20.11.2117 · Cited by 193 · see citing works
The human skin as a hormone target and an endocrine gland
Zouboulis, C. C. (2004) · HORMONES · doi:10.14310/horm.2002.11109 · Cited by 184 · see citing works
Human skin: an independent peripheral endocrine organ
Zouboulis, C. C. (2000) · Hormone Research in Paediatrics · doi:10.1159/000053265 · Cited by 183 · see citing works
Decreased Extracellular-Signal-Regulated Kinase and Increased Stress-Activated MAP Kinase Activities in Aged Human Skin In Vivo
Chung, J. H., Kang, S., Varani, J., Lin, J., Fisher, G. J., & Voorhees, J. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00009.x · Cited by 181 · see citing works
Carotenoids and Protection against Solar UV Radiation
Stahl, W., & Sies, H. (2002) · Skin Pharmacology and Physiology · doi:10.1159/000064532 · Cited by 180 · see citing works
Characteristics and Pathomechanisms of Endogenously Aged Skin
Makrantonaki, E., & Zouboulis, C. C. (2007) · Dermatology · doi:10.1159/000100890 · Cited by 177 · see citing works
Human skin stem cells and the ageing process
Zouboulis, C. C., Adjaye, J., Akamatsu, H., Moe-Behrens, G., & Niemann, C. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.001 · Cited by 176 · see citing works
Self-citation
Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease
Johnson, T. E., Henderson, S. T., Murakami, S., de Castro, E., de Castro, S. H., Cypser, J. R., Rikke, B. A., Tedesco, P., & Link, C. D. (2002) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1015677828407 · Cited by 174 · see citing works
Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast
Sim, G.-S., Lee, B.-C., Cho, H. S., Lee, J. W., Kim, J., Lee, D. H., Kim, J.-H., Pyo, H.-B., Moon, D. C., Oh, K., et al. (2007) · Archives of Pharmacal Research · doi:10.1007/bf02977608 · Cited by 172 · see citing works
Does estrogen prevent skin aging? Results from the First National Health and Nutrition Examination Survey (NHANES I)
Dunn, L. B. (1997) · Archives of Dermatology · doi:10.1001/archderm.133.3.339 · Cited by 172 · see citing works
Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.
Pa, B. (1976) · PubMed · Cited by 168 · see citing works
An Update on the Oxygen Stress–Mitochondrial Mutation Theory of Aging: Genetic and Evolutionary Implications
Miquel, J. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(97)00060-0 · Cited by 167 · see citing works
Skin aging
Yaar, M., & Gilchrest, B. A. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70089-6 · Cited by 166 · see citing works
Vitamins as Hormones
Reichrath, J., Lehmann, B., Carlberg, C., Varani, J., & Zouboulis, C. C. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-958715 · Cited by 164 · see citing works
The influence of hormone replacement therapy on skin ageing
Sator, P. G., Schmidt, J. B., Sator, M. O., Huber, J., & Hönigsmann, H. (2001) · Maturitas · doi:10.1016/s0378-5122(00)00225-5 · Cited by 162 · see citing works
In Vitro Assessment of Keratinocyte Aging
Gilchrest, B. A. (1983) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12541084 · Cited by 160 · see citing works
Cigarette smoke – an aging accelerator?
Bernhard, D., Moser, C. E., Backović, A., & Wick, G. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.016 · Cited by 155 · see citing works
Gene expression profiling in Werner syndrome closely resembles that of normal aging
Kyng, K. J., May, A., Kølvraa, S., & Bohr, V. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2130723100 · Cited by 153 · see citing works
Orally Administered Green Tea Polyphenols Prevent Ultraviolet Radiation-Induced Skin Cancer in Mice through Activation of Cytotoxic T Cells and Inhibition of Angiogenesis in Tumors
Mantena, S. K., Meeran, S. M., Elmets, C. A., & Katiyar, S. K. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2871 · Cited by 150 · see citing works
Ageing and thermal responses during passive heat exposure: sweating and sensory aspects
Dufour, A., & Candas, V. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0396-9 · Cited by 148 · see citing works
PROTECTION AGAINST ULTRAVIOLET B RADIATION‐INDUCED EFFECTS IN THE SKIN OF SKH‐1 HAIRLESS MICE BY A POLYPHENOLIC FRACTION ISOLATED FROM GREEN TEA
Agarwal, R., Katiyar, S. K., Khan, S. G., & Mukhtar, H. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb04954.x · Cited by 142 · see citing works
Suppression of UVB-induced phosphorylation of mitogen-activated protein kinases and nuclear factor kappa B by green tea polyphenol in SKH-1 hairless mice
Afaq, F., Ahmad, N., & Mukhtar, H. (2003) · Oncogene · doi:10.1038/sj.onc.1207035 · Cited by 133 · see citing works
Differential Effects of Photoaging vs Intrinsic Aging on the Vascularization of Human Skin
Chung, J. H., Yano, K., Lee, M. K., Youn, C. S., Seo, J. Y., Kim, K. H., Cho, K. H., Eun, H. C., & Detmar, M. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1437 · Cited by 132 · see citing works
A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence.
Wick, M., Bürger, C., Brüsselbach, S., Lucibello, F. C., & Müller, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32259-7 · Cited by 130 · see citing works
Potential Role of Estrogens in Wound Healing
Ashcroft, G. S., & Ashworth, J. J. (2003) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200304110-00002 · Cited by 130 · see citing works
Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs
Dixon, K. M., Deo, S. S., Wong, G., Slater, M., Norman, A. W., Bishop, J. E., Posner, G. H., Ishizuka, S., Halliday, G. M., Reeve, V. E., et al. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.06.006 · Cited by 127 · see citing works
Tumour necrosis factor-α-induced migration of human Langerhans cells: the influence of ageing: TNF-Α and LANGERHANS CELLS
Bhushan, M., Cumberbatch, M., Dearman, R. J., Andrew, S. M., Kimber, I., & Griffiths, C. E. M. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04549.x · Cited by 126 · see citing works
A study of French centenarians: are ACE and APOE associated with longevity?
Blanché, H., Cabanne, L., Sahbatou, M., & Thomas, G. (2001) · Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie · doi:10.1016/s0764-4469(00)01274-9 · Cited by 126 · see citing works
Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis
Moore, J. O., Wang, Y., Stebbins, W. G., Gao, D., Zhou, X., Phelps, R., Lebwohl, M., & Wei, H. (2006) · Carcinogenesis · doi:10.1093/carcin/bgi367 · Cited by 122 · see citing works
Effect of age on heat-activated sweat gland density and flow during exercise in dry heat
Anderson, R. K., & Kenney, W. L. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.3.1089 · Cited by 119 · see citing works
Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin
Katiyar, S. K. (2002) · International Journal of Oncology · doi:10.3892/ijo.21.6.1213 · Cited by 118 · see citing works
Selective Estrogen Receptor Modulators Accelerate Cutaneous Wound Healing in Ovariectomized Female Mice
Hardman, M. J., Emmerson, E., Campbell, L., & Ashcroft, G. S. (2008) · Endocrinology · doi:10.1210/en.2007-1042 · Cited by 117 · see citing works
Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes
Tzellos, T., Klagas, I., Vahtsevanos, K., Triaridis, S., Printza, A., Kyrgidis, Α., Karakiulakis, G., Zouboulis, C. C., & Papakonstantinou, E. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00889.x · Cited by 116 · see citing works
Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity?
Laron, Z. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.022 · Cited by 115 · see citing works
The effects of ageing on wound healing: immunolocalisation of growth factors and their receptors in a murine incisional model
Ashcroft, G. S., Horan, M. A., & Ferguson, M. W. J. (1997) · Journal of Anatomy · doi:10.1046/j.1469-7580.1997.19030351.x · Cited by 111 · see citing works
Age‐specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro
Makrantonaki, E., Adjaye, J., Herwig, R., Brink, T. C., Groth, D., Hultschig, C., Lehrach, H. R., & Zouboulis, C. C. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00223.x · Cited by 109 · see citing works
1,25-Dihydroxyvitamin D3 and analogues protect primary human keratinocytes against UVB-induced DNA damage
Haes, P. D., Garmyn, M., Verstuyf, A., Clercq, P. D., Vandewalle, M., Degreef, H. J., Vantieghem, K., Bouillon, R., & Segaert, S. (2005) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2004.09.010 · Cited by 108 · see citing works
Aging, anti-aging, and hormesis
Rattan, S. I. S. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.01.006 · Cited by 108 · see citing works
Chronological ageing and photoageing of dendritic cells
Grewe, M. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00898.x · Cited by 106 · see citing works
Curcumin Suppresses AP1 Transcription Factor-dependent Differentiation and Activates Apoptosis in Human Epidermal Keratinocytes
Balasubramanian, S., & Eckert, R. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606003200 · Cited by 100 · see citing works
Sex steroids and cutaneous wound healing: the contrasting influences of estrogens and androgens
Gilliver, S. C., & Ashcroft, G. S. (2007) · Climacteric · doi:10.1080/13697130701456630 · Cited by 100 · see citing works
Expression profiling of aging in the human skin
Lener, T., Moll, P. R., Rinnerthaler, M., Bauer, J. W., Aberger, F., & Richter, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.012 · Cited by 96 · see citing works
Interplay of IGF-I and 17β-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro
Makrantonaki, E., Vogel, K., Fimmel, S., Oeff, M. K., Seltmann, H., & Zouboulis, C. C. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.07.005 · Cited by 94 · see citing works
Endogenous TGF-β Activity Is Modified during Cellular Aging: Effects on Metalloproteinase and TIMP-1 Expression
Zeng, G., McCue, H. M., Mastrangelo, L., & Millis, A. J. T. (1996) · Experimental Cell Research · doi:10.1006/excr.1996.0326 · Cited by 93 · see citing works
The skin as a mirror of the aging process in the human organism – State of the art and results of the aging research in the German National Genome Research Network 2 (NGFN-2)
Makrantonaki, E., & Zouboulis, C. C. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.07.002 · Cited by 86 · see citing works
Chemical exposures, medical history, and risk of squamous and basal cell carcinoma of the skin.
Gallagher, R. P., Bajdik, C. D., Fincham, S. M., Hill, G. B., Keefe, A. R., Coldman, A. J., & McLean, D. I. (1996) · PubMed · Cited by 85 · see citing works
(−)Epigallocatechin-3-gallate inhibits leukocyte elastase: potential of the phyto-factor in hindering inflammation, emphysema, and invasion
Sartor, L., Pezzato, E., & Garbisa, S. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.1.73 · Cited by 85 · see citing works
Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation
Ye, J., Garg, A., Calhoun, C. J., Feingold, K. R., Elias, P. M., & Ghadially, R. (2002) · Experimental Dermatology · doi:10.1034/j.1600-0625.2002.110303.x · Cited by 82 · see citing works
A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women
Sator, P. G., Sator, M. O., Schmidt, J. B., Nahavandi, H., Radaković, S., Huber, J. C., & Hönigsmann, H. (2007) · Climacteric · doi:10.1080/13697130701444073 · Cited by 81 · see citing works
Infrared exposure induces an angiogenic switch in human skin that is partially mediated by heat
Kim, M., Kim, Y. K., Cho, K. H., & Chung, J. H. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07510.x · Cited by 75 · see citing works
Skin aging and sex hormones in women – clinical perspectives for intervention by hormone replacement therapy
Sator, P.-G., Schmidt, J. B., Rabe, T., & Zouboulis, C. C. (2004) · Experimental Dermatology · doi:10.1111/j.1600-0625.2004.00259.x · Cited by 74 · see citing works
Longitudinal effects of age on heat-activated sweat gland density and output in healthy active older men
Inoue, Y. (1996) · European Journal of Applied Physiology · doi:10.1007/bf00376497 · Cited by 72 · see citing works
All-Trans Retinoic Acid Antagonizes UV-Induced VEGF Production and Angiogenesis via the Inhibition of ERK Activation in Human Skin Keratinocytes
Kim, M., Kim, Y. K., Eun, H. C., Cho, K. H., & Chung, J. H. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700463 · Cited by 72 · see citing works
Growth Hormone and Body Composition
Bengtsson, B.-Å., Brummer, R. J., & Bosaeus, I. G. (2008) · Hormone Research · doi:10.1159/000181579 · Cited by 72 · see citing works
Aging and Photoaging Affect Gene Expression in Cultured Human Keratinocytes
Gilchrest, B. A. (1994) · Archives of Dermatology · doi:10.1001/archderm.1994.01690010086013 · Cited by 71 · see citing works
Influence of physiological androgen levels on wound healing and immune status in men
Fimmel, S., & Zouboulis, C. C. (2005) · The Aging Male · doi:10.1080/13685530500233847 · Cited by 70 · see citing works
Aged human skin removes UVB-induced pyrimidine dimers from the epidermis more slowly than younger adult skin in vivo
Yamada, M., Udono, M. U., Hori, M., Hirose, R., Sato, S., Mori, T., & Nikaido, O. (2005) · Archives of Dermatological Research · doi:10.1007/s00403-005-0618-0 · Cited by 62 · see citing works
Androgens and ageing of the skin
Makrantonaki, E., & Zouboulis, C. C. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832b71dc · Cited by 62 · see citing works
Modulation of Replicative Senescence of Diploid Human Cells by Nuclear ERK Signaling
Tresini, M., Lorenzini, A., Torres, C. A., & Cristofalo, V. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604955200 · Cited by 60 · see citing works
Ontogeny of growth hormone receptors in human tissues: an immunohistochemical study
Simard, M., Manthos, H., Giaid, A., Lefèbvre, Y., & Goodyer, C. G. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.8.8768881 · Cited by 59 · see citing works
Nutrition and the skin
Ryan, A. S., & Goldsmith, L. A. (1996) · Clinics in Dermatology · doi:10.1016/0738-081x(96)00068-5 · Cited by 57 · see citing works
Caloric Restriction and Experimental Carcinogenesis
Kritchevsky, D. (2002) · Hybridoma and Hybridomics · doi:10.1089/153685902317401753 · Cited by 56 · see citing works
Betacarotene supplementation protects from photoaging-associated mitochondrial DNA mutation
Eicker, J., Kürten, V., Wild, S., Riss, G., Góralczyk, R., Krutmann, J., & Berneburg, M. (2003) · Photochemical & Photobiological Sciences · doi:10.1039/b300808h · Cited by 55 · see citing works
Pigmentary changes in aged and photoaged skin.
Castanet, J., & Ortonne, J. ‐. (1997) · PubMed · Cited by 54 · see citing works
Genetics of human longevity with emphasis on the relevance of HSP70 as candidate genes
Singh, R. (2007) · Frontiers in bioscience · doi:10.2741/2405 · Cited by 54 · see citing works
A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians
Nebel, A., Flachsbart, F., Till, A., Caliebe, A., Blanché, H., Arlt, A., Häsler, R., Jacobs, G., Kleindorp, R., & Franke, A. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.08.004 · Cited by 53 · see citing works
Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: A pilot study
Patriarca, M. T., Goldman, K. Z., dos Santos, J. M., Petri, V., Simões, R. S., Soares, J. M., Simões, M. D. J., & Baracat, E. C. (2006) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2006.05.024 · Cited by 51 · see citing works
Blood levels of vitamin E, polyunsaturated fatty acids of phospholipids, lipoperoxides and glutathione peroxidase in patients affected with seborrheic dermatitis
Passi, S., Morrone, A., Luca, C. D., Picardo, M., & Ippolito, F. (1991) · Journal of Dermatological Science · doi:10.1016/0923-1811(91)90064-5 · Cited by 46 · see citing works
Paradoxical effects of ?-estradiol on epidermal permeability barrier homeostasis
Tsutsumi, M., & Denda, M. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08115.x · Cited by 46 · see citing works
Skin alterations and diseases in advanced age
Makrantonaki, E., & Zouboulis, C. C. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.05.008 · Cited by 43 · see citing works
Intrinsische Hautalterung
Zouboulis, C. C. (2003) · Der Hautarzt · doi:10.1007/s00105-003-0581-7 · Cited by 42 · see citing works
Effects of Ageing and Physical Training on the Peripheral Sweat Production of the Human Eccrine Sweat Gland
BUONO, M. J., McKENZIE, B. K., & KASCH, F. W. (1991) · Age and Ageing · doi:10.1093/ageing/20.6.439 · Cited by 42 · see citing works
The RAS genes: a homeostatic device in Saccharomyces cerevisiae longevity☆
Jazwinski, S. M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00095-0 · Cited by 41 · see citing works
Metabolic Alterations and Shifts in Energy Allocations Are Corequisites for the Expression of Extended Longevity Genes in Drosophila
Arking, R., Buck, S. A., Hwangbo, D., & Lane, M. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02097.x · Cited by 40 · see citing works
Genomic-driven insights into changes in aging skin.
Robinson, M. K., Binder, R. L., & Griffiths, C. E. M. (2009) · PubMed · Cited by 39 · see citing works
Reduced expression of mRNA for transforming growth factor β(TGFβ) and TGFβ receptors I and II and decreased TGFβ binding to the receptors in in vitro-aged fibroblasts
Mori, Y., Hatamochi, A., Arakawa, M., & Ueki, H. (1998) · Archives of Dermatological Research · doi:10.1007/s004030050282 · Cited by 38 · see citing works
Ageing: A lethal side-effect
Partridge, L., & Gems, D. (2002) · Nature · doi:10.1038/418921a · Cited by 34 · see citing works
Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts
Young, J. J., Patel, A., & Rai, P. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.026 · Cited by 31 · see citing works
Dermatoendokrinologie
Makrantonaki, E., & Zouboulis, C. C. (2010) · Der Hautarzt · doi:10.1007/s00105-009-1889-8 · Cited by 26 · see citing works
Exogenous interleukin-1beta restores impaired Langerhans cell migration in aged skin
Bhushan, M., Cumberbatch, M., Dearman, R. J., Kimber, I., & Griffiths, C. E. M. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05973.x · Cited by 24 · see citing works
Different gene expression of skin tissues between mice with weight controlled by either calorie restriction or physical exercise.
Lü, J., Xie, L., Sylvester, J. E., Wang, J., Bai, J., Baybutt, R. C., & Wang, W. (2007) · PubMed · Cited by 24 · see citing works
Skin cancer in the elderly
Sachs, D. L., Marghoob, A. A., & Halpern, A. C. (2001) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(05)70095-1 · Cited by 20 · see citing works
Emergency Management of Chronic Wounds
Hartoch, R. S., McManus, J. G., Knapp, S., & Buettner, M. F. (2007) · Emergency Medicine Clinics of North America · doi:10.1016/j.emc.2007.01.010 · Cited by 19 · see citing works
Aging and photoaging affect gene expression in cultured human keratinocytes
Gilchrest, B. A. (1994) · Archives of Dermatology · doi:10.1001/archderm.130.1.82 · Cited by 19 · see citing works
Ultraviolet Radiation Attenuates Thrombospondin 1 Expression via PI3K‐Akt Activation in Human Keratinocytes
Kim, M., Oh, Y. J., Lee, S., Kim, J. E., Kim, K. H., & Chung, J. H. (2006) · Photochemistry and Photobiology · doi:10.1562/2005-09-29-ra-702 · Cited by 16 · see citing works
Pigmentary changes in aged and photoaged skin
Castanet, J. (1997) · Archives of Dermatology · doi:10.1001/archderm.133.10.1296 · Cited by 14 · see citing works
Responsiveness to Androgens and Effectiveness of Antisense Oligonucleotides against the Androgen Receptor on Human Epidermal Keratinocytes is Dependent on the Age of the Donor and the Location of Cell Origin
Fimmel, S., Kurfürst, R., Bonté, F., & Zouboulis, C. C. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-961810 · Cited by 13 · see citing works
The Role of Hormones in Intrinsic Aging
Zouboulis, C. C., & Makrantonaki, E. (2006) · Springer eBooks · doi:10.1007/3-540-32953-6_6 · Cited by 12 · see citing works
Practical applications of genomics research for treatment of aging skin.
Kaczvinsky, J. R., & Pe, G. (2009) · PubMed · Cited by 11 · see citing works
Aging, from basic research to pathological applications
Robert, L., & Robert, A. M. (2003) · Pathologie Biologie · doi:10.1016/j.patbio.2003.09.008 · Cited by 5 · see citing works
[Effects of hormones on aging of the CNS, the immune system and the skin in rats].
Ja, F.-T. H. (2004) · PubMed · Cited by 4 · see citing works
From bench to beauty counter: using genomics to drive technology development for skin care.
Tiesman, J. P. (2009) · PubMed · Cited by 3 · see citing works

Flagged first, then by citations

2 of the 149 references couldn’t be matched to a known paper.

Sorted by citations

Oxidative Stress in Aging Human Skin
Rinnerthaler, M., Bischof, J., Streubel, M., Trost, A., & Richter, K. (2015) · Biomolecules · doi:10.3390/biom5020545 · Cited by 1,053 · see citing works
Oxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980 · see citing works
The Dynamics of the Skin’s Immune System
Nguyen, A. V., & Soulika, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081811 · Cited by 719 · see citing works
Advanced glycation end products
Gkogkolou, P., & Böhm, M. (2012) · Dermato-Endocrinology · doi:10.4161/derm.22028 · Cited by 594 · see citing works
Hydrolyzed Collagen—Sources and Applications
León-López, A., Morales-Peñaloza, A., Juárez, V. M. M., Vargas‐Torres, A., Zeugolis, D. I., & Aguirre‐Álvarez, G. (2019) · Molecules · doi:10.3390/molecules24224031 · Cited by 562 · see citing works
Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing
Li, M., Liang, Y., He, J., Zhang, H., & Guo, B. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.0c02823 · Cited by 482 · see citing works
Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review
Davinelli, S., Nielsen, M. E., & Scapagnini, G. (2018) · Nutrients · doi:10.3390/nu10040522 · Cited by 473 · see citing works
Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms
Lephart, E. D. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.001 · Cited by 325 · see citing works
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
Velarde, M. C., Flynn, J. M., Day, N. U., Melov, S., & Campisi, J. (2012) · Aging · doi:10.18632/aging.100423 · Cited by 299 · see citing works
Age-Related Aspects of Cutaneous Wound Healing: A Mini-Review
Sgonc, R., & Gruber, J. (2013) · Gerontology · doi:10.1159/000342344 · Cited by 288 · see citing works
Enhancing Structural Support of the Dermal Microenvironment Activates Fibroblasts, Endothelial Cells, and Keratinocytes in Aged Human Skin In Vivo
Quan, T., Wang, F., Shao, Y., Rittié, L., Xia, W., Orringer, J. S., Voorhees, J. J., & Fisher, G. J. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.364 · Cited by 248 · see citing works
Defining skin aging and its risk factors: A systematic review and meta-analysis
Wong, Q. Y. A., & Chew, F. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-01573-z · Cited by 250 · see citing works
Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging
Gaur, M., Dobke, M. K., & Lunyak, V. V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010208 · Cited by 198 · see citing works
The Skin Microbiome: Current Landscape and Future Opportunities
Smythe, P., & Wilkinson, H. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043950 · Cited by 208 · see citing works
Collagen Derived from Fish Industry Waste: Progresses and Challenges
Rajabimashhadi, Z., Gallo, N., Salvatore, L., & Lionetto, F. (2023) · Polymers · doi:10.3390/polym15030544 · Cited by 192 · see citing works
Age‐related dermal collagen changes during development, maturation and ageing – a morphometric and comparative study
Marcos‐Garcés, V., Aguilar, P. M., Serrano, C. B., García-Bustos, V., Seguí, J. B., Izquierdo, A. F., & Ruiz‐Saurí, A. (2014) · Journal of Anatomy · doi:10.1111/joa.12186 · Cited by 185 · see citing works
Intrinsic skin aging: the role of oxidative stress.
Poljšak, B., Dahmane, R. G., & Godić, A. (2012) · PubMed · Cited by 184 · see citing works
On the role of skin in the regulation of local and systemic steroidogenic activities
Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2015) · Steroids · doi:10.1016/j.steroids.2015.04.006 · Cited by 182 · see citing works
Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies
Pérez-Sánchez, A., Barrajón‐Catalán, E., Herranz‐López, M., & Micol, V. (2018) · Nutrients · doi:10.3390/nu10040403 · Cited by 187 · see citing works
Aesthetic aspects of skin aging, prevention, and local treatment
Zouboulis, C. C., Gancevičienė, R., Liakou, A. Ι., Theodoridis, A., Elewa, R. M., & Makrantonaki, E. (2019) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2019.04.002 · Cited by 172 · see citing works
The Human Epidermal Basement Membrane: A Shaped and Cell Instructive Platform That Aging Slowly Alters
Roig-Rosello, E., & Rousselle, P. (2020) · Biomolecules · doi:10.3390/biom10121607 · Cited by 142 · see citing works
Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin
Vandiver, A. R., Irizarry, R. A., Hansen, K. D., Garza, L. A., Rúnarsson, Á. R., Li, X., Chien, A. L.-L., Wang, T. S., Leung, S. G., Kang, S., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0644-y · Cited by 154 · see citing works
Active ingredients against human epidermal aging
Lorencini, M., Brohem, C. A., Dieamant, G., Zanchin, N. I. T., & Maïbach, H. I. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.03.002 · Cited by 139 · see citing works
Vitamin D in the skin physiology and pathology.
Piotrowska, A., Wierzbicka, J., & Zmijewski, M. A. (2016) · Acta Biochimica Polonica · doi:10.18388/abp.2015_1104 · Cited by 141 · see citing works
Neuroendocrine Aspects of Skin Aging
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112798 · Cited by 137 · see citing works
Biological effects of rutin on skin aging
Choi, S. J., Lee, S.-N., Kim, K., Joo, D. H., Shin, S., Lee, J.-J., Lee, H. K., Kim, J., Kwon, S. B., Kim, M. J., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2604 · Cited by 130 · see citing works
Comparison of Box–Behnken and central composite designs in optimization of fullerene loaded palm-based nano-emulsions for cosmeceutical application
Ngan, C. L., Basri, M., Lye, F. F. A., Masoumi, H. R. F., Tripathy, M., Karjiban, R. A., & Abdulmalek, E. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.05.042 · Cited by 125 · see citing works
Molecular basis of retinol anti‐ageing properties in naturally aged human skin <i>in vivo</i>
Shao, Y., He, T., Fisher, G. J., Voorhees, J. J., & Quan, T. (2017) · International Journal of Cosmetic Science · doi:10.1111/ics.12348 · Cited by 130 · see citing works
Adipocytes in Skin Health and DiseasePreprint
Rivera-Gonzalez, G. C., Shook, B., & Horsley, V. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015271 · Cited by 111 · see citing works
Tannic Acid, A Promising Anti-Photoaging Agent: Evidences of its Antioxidant and Anti-Wrinkle Potentials, and its Ability to Prevent Photodamage and MMP-1 Expression in L929 Fibroblasts Exposed to UVB.
Daré, R. G., Nakamura, C., Ximenes, V., & Lautenschlager, S. O. (2020) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2020.08.019 · Cited by 92 · see citing works
Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients
Stefanadi, E., Dimitrakakis, G., Antoniou, C. K., Challoumas, D., Punjabi, N. P., Dimitrakaki, I. A., Punjabi, S., & Stefanadis, C. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0311-z · Cited by 98 · see citing works
Glycated Reconstructed Human Skin as a Platform to Study the Pathogenesis of Skin Aging
Pennacchi, P. C., de Almeida, M. E. S., Gomes, O. L. A., Faião‐Flores, F., Crepaldi, M. C. D. A., dos Santos, M. F., Barros, S. B. D. M., & Maria–Engler, S. S. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2015.0009 · Cited by 96 · see citing works
Identification of Biomarkers of Human Skin Ageing in Both Genders. Wnt Signalling - A Label of Skin Ageing?
Makrantonaki, E., Brink, T. C., Zampeli, V., Elewa, R. M., Mlody, B., Hossini, A. M., Hermes, B., Krause, U., Knolle, J., Abdallah, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050393 · Cited by 93 · see citing works
Nrf2 a molecular therapeutic target for Astaxanthin
Kohandel, Z., Farkhondeh, T., Aschner, M., & Samarghandian, S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111374 · Cited by 95 · see citing works
Aging is associated with highly defined epigenetic changes in the human epidermis
Raddatz, G., Hagemann, S., Aran, D., Söhle, J., Kulkarni, P. P., Kaderali, L., Hellman, A., Winnefeld, M., & Lyko, F. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-36 · Cited by 93 · see citing works
Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders
Bellei, B., & Picardo, M. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100981 · Cited by 93 · see citing works
A mechanistic view on the aging human skin through ex vivo layer-by-layer analysis of mechanics and microstructure of facial and mammary dermis
Lynch, B., Pageon, H., Blay, H. L., Brizion, S., Bastien, P., Bornschlögl, T., & Domanov, Y. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-04767-1 · Cited by 92 · see citing works
Alterations of the pigmentation system in the aging process
Kang, H. Y., Lee, J. W., Papaccio, F., Bellei, B., & Picardo, M. (2021) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12994 · Cited by 92 · see citing works
Aging and the pathogenic response to burn.
Rani, M., & Schwacha, M. G. (2012) · Europe PMC (PubMed Central) · Cited by 87 · see citing works
Genetics and skin aging
Makrantonaki, E., Bekou, V., & Zouboulis, C. C. (2012) · Dermato-Endocrinology · doi:10.4161/derm.22372 · Cited by 87 · see citing works
The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: a systematic review
Minelli, L., Schrijver, S. D., & Moortgat, P. (2016) · Scars Burns & Healing · doi:10.1177/2059513116676828 · Cited by 86 · see citing works
Dietary advanced glycation end products (dAGEs): An insight between modern diet and health
Tian, Z., Chen, S., Shi, Y., Wang, P., Wu, Y., & Li, G. (2023) · Food Chemistry · doi:10.1016/j.foodchem.2023.135735 · Cited by 84 · see citing works
Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach
Lee, K. E., Bharadwaj, S., Yadava, U., & Kang, S. G. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1596904 · Cited by 81 · see citing works
Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Choi, S.-J., Youn, J., Kim, K., Joo, D. H., Shin, S., Lee, J.-J., Lee, H. K., An, I., Kwon, S., Youn, H. J., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2626 · Cited by 81 · see citing works
Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications
Singh, K. N., Patil, S., & Barkate, H. V. (2019) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13019 · Cited by 81 · see citing works
Wound healing properties of ethyl acetate fraction of Moringa oleifera in normal human dermal fibroblasts
Gothai, S., Arulselvan, P., Tan, W. S., & Fakurazi, S. (2016) · Journal of Intercultural Ethnopharmacology · doi:10.5455/jice.20160201055629 · Cited by 76 · see citing works
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
Alle, Q., Borgne, E. L., Bensadoun, P., Lemey, C., Béchir, N., Gabanou, M., Estermann, F. E., Bertrand‐Gaday, C., Pessemesse, L., Toupet, K., et al. (2022) · Aging Cell · doi:10.1111/acel.13714 · Cited by 75 · see citing works
Geriatric Dermatology Review: Major Changes in Skin Function in Older Patients and Their Contribution to Common Clinical Challenges
Chang, A. L. S., Wong, J. W., Endo, J. O., & Norman, R. A. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.02.014 · Cited by 75 · see citing works
Extrinsic aging: UV-mediated skin carcinogenesis
Tsatsou, F., Trakatelli, M., Patsatsi, A., Kalokasidis, K., & Sotiriadis, D. (2012) · Dermato-Endocrinology · doi:10.4161/derm.22519 · Cited by 74 · see citing works
Review of Major Theories of Skin Aging
Gragnani, A., Cornick, S. M., Chominski, V., de Noronha, S. M. R., de Noronha, S. A. A. C., & Ferreira, L. M. (2014) · Advances in Aging Research · doi:10.4236/aar.2014.34036 · Cited by 75 · see citing works
Skin intervention of fullerene-integrated nanoemulsion in structural and collagen regeneration against skin aging
Ngan, C. L., Basri, M., Tripathy, M., Abedi Karjiban, R., & Abdul-Malek, E. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.01.006 · Cited by 68 · see citing works
Hallmarks of Skin Aging: Update
Jin, S., Li, K., Zong, X., Eun, S., Morimoto, N., & Guo, S. (2023) · Aging and Disease · doi:10.14336/ad.2023.0321 · Cited by 67 · see citing works
Anesthesia, Microcirculation, and Wound Repair in Aging
Bentov, I., & Reed, M. J. (2013) · Anesthesiology · doi:10.1097/aln.0000000000000036 · Cited by 64 · see citing works
Application of Cell Therapy for Anti-Aging Facial Skin
Zarei, F., & Abbaszadeh, A. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x13666181113113415 · Cited by 63 · see citing works
Skin aging by glycation: lessons from the reconstructed skin model
Pageon, H., Zucchi, H., Rousset, F., Monnier, V. M., & Asselineau, D. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2013-0091 · Cited by 62 · see citing works
Management of burns in the elderly.
Abu-Sittah, G. S., Chahine, F., & Janom, H. (2016) · Europe PMC (PubMed Central) · Cited by 60 · see citing works
Aging in the sebaceous gland
Hou, X., Wei, Z., Zouboulis, C. C., & Ju, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.909694 · Cited by 65 · see citing works
Chemical Constituents from Leaves of Hydrangea serrata and Their Anti-photoaging Effects on UVB-Irradiated Human Fibroblasts
Shin, J., Han, H.-S., Lee, S.-B., Myung, D.-B., Lee, K., Lee, S. H., Kim, H. J., & Lee, K. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00742 · Cited by 56 · see citing works
Age-dependent variation in cytokines, chemokines and biologic analytes rinsed from the surface of healthy human skin
Kinn, P., Holdren, G. O., Westermeyer, B. A., Abuissa, M., Fischer, C. L., Fairley, J. A., Brogden, K. A., & Brogden, N. K. (2015) · Scientific Reports · doi:10.1038/srep10472 · Cited by 57 · see citing works
Skin health in older age
Al‐Nuaimi, Y., Sherratt, M. J., & Griffiths, C. E. M. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.08.005 · Cited by 57 · see citing works
MicroRNAs in human skin ageing
Mancini, M., Lena, A. M., Saintigny, G., Mahé, C., Daniele, N. D., Melino, G., & Candi, E. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.04.003 · Cited by 53 · see citing works
Targeting organ-specific mitochondrial dysfunction to improve biological aging
Madreiter‐Sokolowski, C. T., Hiden, U., Krstić, J., Panzitt, K., Wagner, M., Enzinger, C., Khalil, M., Abdellatif, M., Malle, E., Madl, T., et al. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108710 · Cited by 54 · see citing works
Protective effect of neglected plant Diplocyclos palmatus on quorum sensing mediated infection of Serratia marcescens and UV-A induced photoaging in model Caenorhabditis elegans
Alexpandi, R., Prasanth, M. I., Ravi, A. V., Balamurugan, K., Durgadevi, R., Ramanathan, S., Mesquita, J. F. D., & Pandian, S. K. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111637 · Cited by 51 · see citing works
Dermal Fibroblasts as the Main Target for Skin Anti-Age Correction Using a Combination of Regenerative Medicine Methods
Zorina, A. I., Zorin, V. L., Isaev, A. A., Kudlay, D. A., Vasileva, M., & Kopnin, P. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45050247 · Cited by 51 · see citing works
Research Progress in Skin Aging and Immunity
He, X., Gao, X., & Xie, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074101 · Cited by 48 · see citing works
Immunological Aspects of Skin Aging in Atopic Dermatitis
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115729 · Cited by 50 · see citing works
Skin Immunosenescence and Type 2 Inflammation: A Mini-Review With an Inflammaging Perspective
Chen, B., Yang, J., Song, Y., Zhang, D., & Hao, F. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.835675 · Cited by 47 · see citing works
Effect of oral administration of collagen hydrolysates from Nile tilapia on the chronologically aged skin
Wang, L., Jiang, Y. C., Wang, X., Zhou, J., Cui, H., Xu, W., He, Y., Ma, H., & Gao, R. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.03.005 · Cited by 47 · see citing works
Development of an Aged Full-Thickness Skin Model Using Flexible Skin-on-a-Chip Subjected to Mechanical Stimulus Reflecting the Circadian Rhythm
Jeong, S., Kim, J., Jeon, H. M., Kim, K., & Sung, G. Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312788 · Cited by 46 · see citing works
Antioxidant Thermogelling Formulation for Burn Wound Healing
Liu, M., Chen, Y., Zhu, Q., Tao, J., Tang, C., Ruan, H., Wu, Y., & Loh, X. J. (2022) · Chemistry - An Asian Journal · doi:10.1002/asia.202200396 · Cited by 46 · see citing works
Biological Effects Induced by Specific Advanced Glycation End Products in the Reconstructed Skin Model of Aging
Pageon, H., Zucchi, H., Dai, Z., Sell, D. R., Strauch, C., Monnier, V. M., & Asselineau, D. (2015) · BioResearch open access · doi:10.1089/biores.2014.0053 · Cited by 45 · see citing works
Biomarkers of skin aging
Kanaki, T., Makrantonaki, E., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9392-x · Cited by 46 · see citing works
Skin Health Connected to the Use of Absorbent Hygiene Products: A Review
Bender, J., Faergemann, J., & Sköld, M. (2017) · Dermatology and Therapy · doi:10.1007/s13555-017-0189-y · Cited by 45 · see citing works
Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice
Wang, Z., Wang, Q., Wang, L., Xu, W., He, Y., Li, Y., He, S., & Ma, H. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8098 · Cited by 44 · see citing works
Endocrine-disrupting chemicals and skin manifestations
Ju, Q., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9371-2 · Cited by 43 · see citing works
Dietary Monounsaturated Fatty Acids Intake and Risk of Skin Photoaging
Latreille, J., Kesse‐Guyot, E., Malvy, D. J.-M., Andreeva, V. A., Galan, P., Tschachler, E., Herçberg, S., Guinot, C., & Ezzedine, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044490 · Cited by 43 · see citing works
When the skin is in the center of interest: An aging issue
Zouboulis, C. C., Makrantonaki, E., & Nikolakis, G. D. (2019) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2019.04.004 · Cited by 44 · see citing works
Gender Differences in Skin Aging and the Changing Profile of the Sex Hormones with Age
Farage, M. A. (2012) · Journal of Steroids & Hormonal Science · doi:10.4172/2157-7536.1000109 · Cited by 41 · see citing works
Galangin suppresses H2O2‐induced aging in human dermal fibroblasts
Wen, S., Chen, J., Weng, Y., Aneja, R., Chen, C., Huang, C., & Kuo, W. (2017) · Environmental Toxicology · doi:10.1002/tox.22455 · Cited by 41 · see citing works
Skin mirrors human aging
Nikolakis, G. D., Makrantonaki, E., & Zouboulis, C. C. (2013) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2013-0018 · Cited by 40 · see citing works
Chronic actinic damage of facial skin
Bilaç, C., Şahin, M. T., & Öztürkcan, S. (2014) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2014.02.014 · Cited by 39 · see citing works
Management of the Skin and Soft Tissue in the Geriatric Surgical Patient
Greenhalgh, D. G. (2014) · Surgical Clinics of North America · doi:10.1016/j.suc.2014.09.008 · Cited by 39 · see citing works
Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation
Weiland, D., Brachvogel, B., Hornig‐Do, H., Neuhaus, J., Holzer, T., Tobin, D. J., Niessen, C. M., Wiesner, R. J., & Baris, O. R. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.08.019 · Cited by 39 · see citing works
The anti‐ageing effects of a natural peptide discovered by artificial intelligence
Kennedy, K. P., Cal, R., Casey, R., Lopez, C., Adelfio, A., Molloy, B., Wall, A. M., Holton, T. A., & Khaldi, N. (2020) · International Journal of Cosmetic Science · doi:10.1111/ics.12635 · Cited by 39 · see citing works
Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent
Daré, R. G., Kolanthai, E., Neal, C. J., Fu, Y., Seal, S., Nakamura, C. V., & Lautenschlager, S. O. S. (2023) · Antioxidants · doi:10.3390/antiox12010190 · Cited by 38 · see citing works
Dermatological problems of the puberty
Bergler-Czop, B. S., & Brzezińska-Wcisło, L. A. (2013) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2013.35621 · Cited by 39 · see citing works
Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin
Markiewicz, E., Jerome, J., Mammone, T., & Idowu, O. C. (2022) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s364538 · Cited by 38 · see citing works
Age related changes in the dermal mast cells and the associated changes in the dermal collagen and cells: A histological and electron microscopy study
Hafez, S. M. N. A. (2019) · Acta Histochemica · doi:10.1016/j.acthis.2019.05.004 · Cited by 35 · see citing works
Skin differences based on age and chronicity of ultraviolet exposure: results from a gene expression profiling study
McGrath, J. A., Robinson, M. K., & Binder, R. L. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.10860.x · Cited by 35 · see citing works
Novel methods of drug administration for the treatment and care of older patients
Quinn, H. L., Hughes, C. M., & Donnelly, R. F. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.050 · Cited by 34 · see citing works
State of the Science Burn Research: Burns in the Elderly
Jeschke, M. G., Phelan, H. A., Wolf, S. C., Romanowski, K. S. S., Rehou, S., Saetamal, A., Weber, J., Schulz, J., New, C., Wiktor, A. J., et al. (2020) · Journal of Burn Care & Research · doi:10.1093/jbcr/irz163 · Cited by 34 · see citing works
Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
Klinngam, W., Rungkamoltip, P., Thongin, S., Joothamongkhon, J., Khumkhrong, P., Khongkow, M., Namdee, K., Tepaamorndech, S., Chaikul, P., Kanlayavattanakul, M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112461 · Cited by 34 · see citing works
Protective Effect of Djulis (Chenopodium formosanum) Extract against UV- and AGEs-Induced Skin Aging via Alleviating Oxidative Stress and Collagen Degradation
Lyu, J.-L., Liu, Y.-J., Wen, K., Chiu, C., Lin, Y.-H., & Chiang, H. (2022) · Molecules · doi:10.3390/molecules27072332 · Cited by 34 · see citing works
The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials
Zhang, X., Zhou, Q., Qi, Y., Chen, X., Deng, J., Zhang, Y., Li, R., & Fan, J. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2164557 · Cited by 39 · see citing works
Decreased proliferative capacity of aged dermal fibroblasts in a three dimensional matrix is associated with reduced IGF1R expression and activation
Bentov, I., Damodarasamy, M., Plymate, S. R., & Reed, M. J. (2014) · Biogerontology · doi:10.1007/s10522-014-9501-8 · Cited by 32 · see citing works
Glycation: The angiogenic paradox in aging and age-related disorders and diseases
Roca, F., Grossin, N., Chassagne, P., Puisieux, F. L., & Boulanger, É. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.03.009 · Cited by 33 · see citing works
Choline chloride-based deep eutectic solvent as an inhibitor of metalloproteases (collagenase and elastase) in cosmetic formulation
Buarque, F. S., Silva, S. A. M. E., & Ribeiro, B. D. (2023) · 3 Biotech · doi:10.1007/s13205-023-03602-2 · Cited by 31 · see citing works
Nested PCR-denaturing gradient gel electrophoresis analysis of human skin microbial diversity with age
Li, W., Han, L., Yu, P., Ma, C., Wu, X., & Xu, J. (2014) · Microbiological Research · doi:10.1016/j.micres.2014.02.008 · Cited by 30 · see citing works
In vivo and qualitative studies investigating the translational potential of microneedles for use in the older population
Quinn, H. L., Hughes, C. M., & Donnelly, R. F. (2017) · Drug Delivery and Translational Research · doi:10.1007/s13346-017-0393-4 · Cited by 29 · see citing works

Authors: Zouboulis, C. C., & Makrantonaki, E.
Affiliations: Städtisches Klinikum Dessau (DE)
Corresponding author: Zouboulis, Christos C.
ORCID: Zouboulis, Christos C.
Makrantonaki, Evgenia
Venue: Clinics in Dermatology
Publisher: Elsevier BV
Published: 2011-01
Volume: 29
Issue: 1
Pages: 3-14
ISSN: 0738-081X (ISSN-L)
DOI: 10.1016/j.clindermatol.2010.07.001
OpenAlex: W2025725196
Cited by: 341
References: 149
Citations by year: 2026: 12 · 2025: 15 · 2024: 14 · 2023: 25 · 2022: 25 · 2021: 24 · 2020: 28 · 2019: 27 · 2018: 20 · 2017: 26 · 2016: 35 · 2015: 25 · 2014: 26 · 2013: 16 · 2012: 20
FWCI: 2.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinics in Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: skin aging, skin permeability, wound healing, angiogenesis, lipogenesis, sweating, skin immune function, vitamin D synthesis, progeroid syndromes, DNA repair, mitochondrial function, apoptosis, extracellular matrix, cellular metabolism, carcinogenesis, healthy aging, sun protection, sunscreen use, gene expression profiling
MeSH terms: Animals, Humans, Nutritional Physiological Phenomena, Skin, Skin Diseases, Skin Physiological Phenomena, Sunscreening Agents, Skin Aging, Genomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinical aspects and molecular diagnostics of skin aging

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks