Particulate matter 2.5 regulates lipid synthesis and inflammatory cytokine production in human SZ95 sebocytes
Open accessAbstract
A large body of evidence indicates that particulate matter (PM)2.5 is associated with various negative effects on human health. However, the impact and molecular mechanism of PM2.5 on the skin have not been elucidated. Therefore, the present study aimed to investigate the effects of two types of PM2.5 [water-soluble extracts (W-PM2.5) and non-water-soluble extracts (NW-PM2.5)] on cell proliferation, cell cycle progression, lipid synthesis, and inflammatory cytokine production of human SZ95 sebocytes. The results demonstrated that NW-PM2.5 and W-PM2.5 exposure dose-dependently inhibited SZ95 sebocyte proliferation by inducing G1 cell arrest. Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1α (IL-1α), IL-6 and IL-8 in SZ95 sebocytes. Additionally, the expression of aryl hydrocarbon (Ah) receptor (AhR), AhR nuclear translocator protein (ARNT), as well as cytochrome P450 1A1 were significantly increased following PM2.5 exposure. Thus, these findings indicate that PM2.5 exerts inhibitory effects on cell proliferation and lipid synthesis, and stimulatory effects on inflammatory cytokine production and AhR signaling activation in human SZ95 sebocytes.
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AHR activation and increased CYP1A1 expression have also been reported after exposure to B[a]P, PM2.5 and water-soluble tobacco smoke extracts.
“AHR activation and increased CYP1A1 expression have also been reported after exposure to B[a]P,38 PM2.5 39 and water‐soluble tobacco smoke extracts.40”
From The impact of airborne pollution on skin (2019) · cites this paper as [39]
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- Authors
- Liu, Q., Wu, J., Song, J., Liang, P., Zheng, K., Xiao, G., Liu, L., Zouboulis, C. C., & Lei, T.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Corresponding author
- Lei, Tiechi
- Venue
- International Journal of Molecular Medicine
- Publisher
- Spandidos Publications
- Published
- 2017-08-25
- Volume
- 40
- Issue
- 4
- Pages
- 1029-1036
- ISSN
- 1107-3756 (ISSN-L)
- 1791-244X
- PMC
- PMC5593471
- OpenAlex
- W2750447302
- Cited by
- 30
- References
- 37
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 2
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- International Journal of Molecular Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- particulate matter 2.5, air pollution, sebocytes, inflammatory cytokines, interleukin-1 alpha, interleukin-6, interleukin-8, cell proliferation, G1 cell cycle arrest, aryl hydrocarbon receptor, ARNT, CYP1A1, skin health
- MeSH terms
- Cell Line, Transformed, Epithelial Cells, Gene Expression Regulation, Humans, Sebaceous Glands, Signal Transduction, Interleukin-6, Interleukin-8, Receptors, Aryl Hydrocarbon, Cytochrome P-450 CYP1A1, Complex Mixtures, Cell Proliferation, Lipid Metabolism, Aryl Hydrocarbon Receptor Nuclear Translocator, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Particulate Matter, Interleukin-1alpha, G1 Phase Cell Cycle Checkpoints
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