Cited by 44Genetically Modified Organisms ResearchAgricultural safety and regulationsInsect Resistance and Genetics

Safety of Pseudomonas chlororaphis as a gene source for genetically modified crops

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Anderson, Jennifer A., Staley, Jamie, Challender, Mary, Heuton, Jamie·2018·Transgenic Research

Abstract

Genetically modified crops undergo extensive evaluation to characterize their food, feed and environmental safety prior to commercial introduction, using a well-established, science-based assessment framework. One component of the safety assessment includes an evaluation of each introduced trait, including its source organism, for potential adverse pathogenic, toxic and allergenic effects. Several Pseudomonas species have a history of safe use in agriculture and certain species represent a source of genes with insecticidal properties. The ipd072Aa gene from P. chlororaphis encodes the IPD072Aa protein, which confers protection against certain coleopteran pests when expressed in maize plants. P. chlororaphis is ubiquitous in the environment, lacks known toxic or allergenic properties, and has a history of safe use in agriculture and in food and feed crops. This information supports, in part, the safety assessment of potential traits, such as IPD072Aa, that are derived from this source organism.

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  • Effective toxins have been isolated from other bacteria including species of Pseudomonas and Chromobacter that might be expressed in future insect-resistant GE plants.

    “In addition to Bt, effective toxins have also been isolated from other bacteria including species of Pseudomonas (Anderson et al., 2018) and Chromobacter (Sampson et al. 2017) that might be expressed in future insect-resistant GE plants.”

    From Genetically engineered crops help support conservation biological control (2019) · cites this paper as Anderson et al., 2018

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  1. Montie TC Pseudomonas vol 10. Biotechnology Handbooks 1998 New York Springer

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Authors
Anderson, J. A., Staley, J., Challender, M., & Heuton, J.
Affiliations
Pioneer Hi-Bred (US)
Corresponding author
Anderson, Jennifer A.
Venue
Transgenic Research
Published
2018-02
Volume
27
Issue
1
Pages
103-113
ISSN
  • 0962-8819 (ISSN-L)
  • 1573-9368
OpenAlex
W2792678916
Cited by
44
References
41
Citations by year
2026: 1 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 2 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 3
FWCI
5.09
Type
journal article
Language
en
Open access
Locations
  • Transgenic Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
U.S. Environmental Protection Agency
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Keywords
Pseudomonas chlororaphis, genetically modified crops, safety assessment, insecticidal proteins, maize, allergenicity, toxicity, pathogenicity
MeSH terms
Pseudomonas chlororaphis, Bacterial Proteins, Zea mays, Insecticides, Phylogeny, Crops, Agricultural, Plants, Genetically Modified, Biological Control Agents

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