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Acute phase proteins in cattle after exposure to complex stress
Abstract
Stressors such as weaning, mixing and transportation have been shown to lead to increased blood concentrations of acute phase proteins (APP), including serum amyloid A (SAA) and haptoglobin, in calves. This study was therefore undertaken to assess whether SAA and haptoglobin levels in blood mirror stress in adult cattle. Six clinically healthy Holstein cows and two Holstein heifers were transported for four to six hours to a research facility, where each animal was housed in solitary tie stalls. Blood samples for evaluation of leukocyte counts and serum SAA and haptoglobin concentrations were obtained before (0-sample) and at 8, 24 and 48 hours after the start of transportation. Upon arrival the animals gave the impression of being anxious, and they appeared to have difficulty coping with isolation and with being tied on the slippery floors of the research stable. Serum concentrations of SAA and haptoglobin increased significantly in response to the stressors (P < 0.01 and 0.05 at 48 hours, respectively). Additionally, the animals had transient neutrophilia at 8 and 24 hours (P < 0.05). In conclusion, the results of the study suggest that SAA and haptoglobin may serve as markers of stress in adult cattle.
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“Haptoglobin is an acute phase protein which increases as a result of stressors such as weaning, transportation, and disease (Lomborg et al., 2008).”
From A randomized controlled trial evaluating the effect of providing a rest period during long-distance transportation of surplus dairy calves: Part II. Effect on hematological variables (2024) · cites this paper as Lomborg et al., 2008
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Metadata
- Authors
- Lomborg, S. R., Nielsen, L. R., Heegaard, P. M. H., & Jacobsen, S.
- Affiliations
- University of Copenhagen (DK)
- Technical University of Denmark (DK)
- Corresponding author
- Jacobsen, S.
- Venue
- Veterinary Research Communications
- Published
- 2008-05-07
- Volume
- 32
- Issue
- 7
- Pages
- 575-582
- ISSN
- 0165-7380 (ISSN-L)
- 1573-7446
- OpenAlex
- W1993821464
- Cited by
- 159
- References
- 26
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 11 · 2022: 12 · 2021: 14 · 2020: 10 · 2019: 14 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 4 · 2014: 12 · 2013: 9 · 2012: 10
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Veterinary Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Behavior and Welfare Studies
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
- Keywords
- acute phase proteins, serum amyloid A, haptoglobin, cattle stress, transport stress, stress symptoms, neutrophilia, Holstein cows, Holstein heifers, isolation stress, tie stalls
- MeSH terms
- Acute-Phase Proteins, Animals, Anxiety, Behavior, Animal, Cattle, Female, Haptoglobins, Stress, Physiological, Transportation
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