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Cited by 1,060Animal health and immunologyBiomarkers in Disease MechanismsSepsis Diagnosis and Treatment

Application of acute phase protein measurements in veterinary clinical chemistry

Open access
Petersen, Henrik Hagbard, Nielsen, Jens Peter, Heegaard, Peter Mikael Helweg·2004·Veterinary Research
DOI 10.1051/vetres:2004002
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Abstract

The body's early defence in response to trauma, inflammation or infection, the acute phase response, is a complex set of systemic reactions seen shortly after exposure to a triggering event. One of the many components is an acute phase protein response in which increased hepatic synthesis leads to increased serum concentration of positive acute phase proteins. The serum concentration of these acute phase proteins returns to base levels when the triggering factor is no longer present. This paper provides a review of the acute phase proteins haptoglobin, C-reactive protein and serum amyloid A and their possible use as non-specific indicators of health in large animal veterinary medicine such as in the health status surveillance of pigs at the herd level, for the detection of mastitis in dairy cattle and for the prognosis of respiratory diseases in horses.

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Crossref · 10.1051/vetres:2004002

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  • Early detection of APPs in serum may occur as soon as 4 h post-exposure in SAA or CRP or later at 24-48 h in Hp or Fb.

    “Early detection of APPs in serum may occur as soon as 4 h post-exposure in SAA or CRP or later at 24–48 h in Hp or Fb [262].”

    From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [262]

    The Common Functions Reference section says serum SAA and CRP increase within four hours and describes Hp as increasing later. It gives 24–48 hours as the typical time to maximum APP concentration, not the time when Hp or fibrinogen first becomes detectable; the passages do not establish that timing for fibrinogen. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cites

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Research works printed but not linked: 17

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  2. Beck G., Habicht G.S., Isolation and charac- terisation of a primitive interleukin-1 like protein from an invertebrate, Asterias forbesi, Proc. Natl. Acad. Sci. USA 83 (1986) 7429- 7433.
  3. Fiedel B.A., Simpson R.M., Gewurz H., Effects of C-reactive protein (CRP) on plate- let function, in: Kushner I., Volankis J.E., Gewurz H. (Eds.), C-reactive protein and the plasma protein response to tissue injury, The New York Academy of Science 389, New York, 1982, pp. 263-273.
  4. Gruys E., Touissant M.J.M., Landman W.J.M., Tivapasi M., Chamanza R., van Veen L., Infection, inflammation and stress inhibit growth. Mechanisms and non-specific assessment of the processes by acute phase proteins, in: Wensing T. (Ed.), Production diseases in farm animals, 2, Wageningen Press, The Netherlands, 1999, pp. 72-87.
  5. Kushner I., The phenomenon of the acute phase response, in: Kushner I., Volanakis J.E., Gewurz H. (Eds.), C-reactive protein and the plasma protein response to tissue injury, The New York Academy of Science 389, New York, 1982, pp. 39-48.
  6. Mackiewicz A., Kushner I., Baumann H., Acute phase proteins molecular biology, biochemistry, and clinical applications, CRC Press, Boca Raton, 1993.
  7. Mold C., Du Clos T.W., Nakayama S., Edwards K.M., Gewurz H., C-reactive pro- tein reactivity with complement and effects on phagocytosis, in: Kushner I., Volankis J.E., Gewurz H. (Eds.), C-reactive protein and the plasma protein response to tissue injury, The New York Academy of Science 389, New York, 1982, pp. 251-262.
  8. Molenaar A., Rajan G., Pearson M., Miles M., Petrova R., Davis S., Stelwagen K., A serum amyloid protein homologue is expressed by the mammary gland in a similar pattern to lactoferrin, Proceedings of the 3rd European Colloquium on food safety and acute phase proteins, Doorn, The Netherlands, 2002.
  9. Putnam F.W., Haptoglobin, in: Putnam F.W. (Ed.), The plasma proteins, Academic Press, 1975.
  10. Saloniemi H., Use of somatic cell count in udder health work, in: Sandholm M., Honkanen-Buzalski T., Kaartinen L., Pyörälä S. (Eds.), The bovine udder and mastitis, Uni- versity of Helsinki, Helsinki, Finland, ISBN 951-834-047-1, 1995, pp. 105-110.
  11. Sipe J.D., Acute phase proteins in chronic inflammation, in: Koj A. (Ed.), The acute phase response to injury and infection, Else- vier, 1985, pp. 273-284.
  12. Straw B.E., Meuten D.J., Thacker B.J., Physical examination and diagnosis, in: Straw B.E., D'Allaire S.D., Mengeling W.L., Tailor D.J. (Eds.), Diseases of swine, 8(1), Blackwell Science Ltd., 1999, pp. 3-18.
  13. Vilcék J., Le J., Immunology of cytokines: An introduction, in: Thomson A.W. (Ed.), The Cytokine Handbook, Academic Press, 1991, pp. 1-17.
  14. Volanakis J.E., Complement activation by C-reactive protein complexes, in: Kushner I., Volanakis J.E., Gewurz H. (Eds.), C-reac- tive protein and the plasma protein response to tissue injury, The New York Academy of Science 389, New York, 1982, pp. 235-250.
  15. Whicher J.T., Dieppe P.A., Acute phase pro- teins, in: Thompson R.A. (Ed.), Clinics in immunology and allergy, Vol. 5(3), W.B. Saunders, London, 1985, pp. 425-446.
  16. Xu L., Badolato R., Murphy W.J., Longo D.L., Anver M., Hale S., Oppenheim J.J., To access this journal online: www.edpsciences.org
  17. Yoo J.-Y., Desiderio S., Innate and acquired immunity intersect in a global view of the acute-phase response, Proc. Natl. Acad. Sci. USA 100 (2003) 1157-1162.

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Authors
Petersen, H. H., Nielsen, J. P., & Heegaard, P. M. H.
ORCID
Venue
Veterinary Research
Publisher
EDP Sciences
Published
2004-03
Volume
35
Issue
2
Pages
163-187
ISSN
  • 0928-4249 (ISSN-L)
  • 1297-9716
DOI
10.1051/vetres:2004002
OpenAlex
W2125954029
Cited by
1,060
References
6
Citations by year
2026: 30 · 2025: 26 · 2024: 39 · 2023: 61 · 2022: 67 · 2021: 47 · 2020: 54 · 2019: 57 · 2018: 67 · 2017: 48 · 2016: 45 · 2015: 62 · 2014: 58 · 2013: 77 · 2012: 44
FWCI
5.84
Type
journal article
Language
en
Open access
Locations
  • Veterinary Research (publishedVersion)
  • PubMed (publishedVersion)
  • Springer Link (Chiba Institute of Technology) (submittedVersion)
  • HAL (submittedVersion, other-oa)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
Topics
  • Health Sciences › Veterinary › Small Animals › Animal health and immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords
acute phase proteins, acute phase response, haptoglobin, C-reactive protein, serum amyloid A, inflammatory markers, large animal medicine
MeSH terms
Acute-Phase Proteins, Serum Amyloid A Protein, Animals, Apolipoproteins, C-Reactive Protein, Cattle, Female, Haptoglobins, Horse Diseases, Horses, Mastitis, Bovine, Respiratory Tract Infections, Swine, Swine Diseases

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