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Cited by 36Adenosine and Purinergic SignalingHearing, Cochlea, Tinnitus, GeneticsIon Channels and Receptors

Damage-induced cell–cell communication in different cochlear cell types via two distinct ATP-dependent Ca2+ waves

Open access
Lahne, Manuela, Gale, Jonathan E.·2010·Purinergic Signalling
DOI 10.1007/s11302-010-9193-8PMC PMC2912991
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Abstract

Unlabelled Intercellular Ca(2+) waves can coordinate the action of large numbers of cells over significant distances. Recent work in many different systems has indicated that the release of ATP is fundamental for the propagation of most Ca(2+) waves. In the organ of hearing, the cochlea, ATP release is involved in critical signalling events during tissue maturation. ATP-dependent signalling is also implicated in the normal hearing process and in sensing cochlear damage. Here, we show that two distinct Ca(2+) waves are triggered during damage to cochlear explants. Both Ca(2+) waves are elicited by extracellular ATP acting on P2 receptors, but they differ in their source of Ca(2+), their velocity, their extent of spread and the cell type through which they propagate. A slower Ca(2+) wave (14 mum/s) communicates between Deiters' cells and is mediated by P2Y receptors and Ca(2+) release from IP(3)-sensitive stores. In contrast, a faster Ca(2+) wave (41 mum/s) propagates through sensory hair cells and is mediated by Ca(2+) influx from the external environment. Using inhibitors and selective agonists of P2 receptors, we suggest that the faster Ca(2+) wave is mediated by P2X(4) receptors. Thus, in complex tissues, the expression of different receptors determines the propagation of distinct intercellular communication signals.Electronic supplementary material The online version of this article (doi:10.1007/s11302-010-9193-8) contains supplementary material, which is available to authorized users.

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  • Ex vivo cochlear calcium waves slow from an initial velocity of 10-15 μm/s with distance from the site of lesion.

    “Similarly to those in living skin, ex vivo cochlear calcium waves slow from an initial velocity of 10–15 μm/s with distance from the site of lesion (13, 24).”

    From Damage-evoked signals in cochlear neurons and supporting cells (2024) · cites this paper as [13]

    The Results (page not available in our copy) report a cochlear calcium wave travelling at 13.7 ± 0.5 μm/s, within the claimed range. But that is the measured velocity of a distinct slower wave, not an initial velocity that declines with distance; the same section reports a separate faster wave at 40.7 ± 5.4 μm/s. The reported reduction with distance concerns calcium-signal magnitude, not wave speed. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Damage elicits spreading calcium waves within cochlear epithelia.

    “Also like in skin, damage elicits spreading calcium waves within cochlear epithelia.”

    From Damage-evoked signals in cochlear neurons and supporting cells (2024) · cites this paper as [13]

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Research works printed but not linked: 3

  1. Guo C, Masin M, Qureshi OS, Murrell-Lagnado RD (2007) Evidence for functional P2X 4 /P2X 7 heteromeric receptors. Mol Pharmacol 72(6):1447-1456
  2. Surprenant A, Rassendren F, Kawashima E, North RA, Buell G (1996) The cytolytic P2Z receptor for extracellular atp identified as a P2X receptor (P2X 7 ). Science 272(5262):735-738
  3. Jarlebark LE, Housley GD, Thorne PR (2000) Immunohistochemical localization of adenosine 5′-triphosphate-gated ion channel P2X(2) receptor subunits in adult and developing rat cochlea. J Comp Neurol 421(3):289-301

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Authors
Lahne, M., & Gale, J. E.
Affiliations
University College London (GB)
Corresponding author
Gale, Jonathan E.
ORCID
Venue
Purinergic Signalling
Publisher
Springer Science and Business Media LLC
Published
2010-06
Volume
6
Issue
2
Pages
189-200
ISSN
  • 1573-9538 (ISSN-L)
  • 1573-9546
DOI
10.1007/s11302-010-9193-8
PMC
PMC2912991
OpenAlex
W2036698172
Cited by
36
References
44
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 3 · 2013: 4 · 2012: 3
FWCI
1.53
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Purinergic Signalling (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
calcium waves, extracellular ATP, P2X4 receptor, P2Y receptors, cochlear damage, Deiters' cells, hair cells, cochlea, IP3 receptor, ATP release

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