A mechanism for sensing noise damage in the inner ear
Open accessAbstract
Our sense of hearing requires functional sensory hair cells. Throughout life those hair cells are subjected to various traumas, the most common being loud sound. The primary effect of acoustic trauma is manifested as damage to the delicate mechanosensory apparatus of the hair cell stereocilia. This may eventually lead to hair cell death and irreversible deafness. Little is known about the way in which noxious sound stimuli affect individual cellular components of the auditory sensory epithelium. However, studies in different types of cell cultures have shown that damage and mechanical stimulation can activate changes in intracellular free calcium concentration ([Ca(2+)](i)) and elicit intercellular Ca(2+) waves. Thus an attractive hypothesis is that changes in [Ca(2+)](i), propagating as a wave through support cells in the organ of Corti, may constitute a fundamental mechanism to signal the occurrence of hair cell damage. The mechanism we describe here exhibits nanomolar sensitivity to extracellular ATP, involves regenerative propagation of intercellular calcium waves due to ATP originating from hair cells, and depends on functional IP(3)-sensitive intracellular stores in support cells.
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Damage elicits spreading calcium waves within cochlear epithelia.
“Also like in skin, damage elicits spreading calcium waves within cochlear epithelia.”
From Damage-evoked signals in cochlear neurons and supporting cells (2024) · cites this paper as [12]
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“, 2015), presumably from supporting cells (Gale et al., 2004; Lahne and Gale, 2008, 2010).”
BackgroundMethodResultInfluentialDamage-evoked signals in cochlear neurons and supporting cells
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“Of equal importance, it is known that local damage in cochlear explants can trigger intercellular calcium signals that propagate through surrounding epithelia (12, 13).”
BackgroundMethod
- Authors
- Gale, J. E., Piazza, V., Ciubotaru, C. D., & Mammano, F.
- Affiliations
- University College London (GB)
- Veneto Institute of Molecular Medicine (IT)
- University of Padua (IT)
- Corresponding author
- Gale, Jonathan E
- Mammano, Fabio
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 14
- Issue
- 6
- Pages
- 526-529
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2095198088
- Cited by
- 149
- References
- 16
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 7
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3425 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- noise-induced hearing loss, acoustic trauma, hair cell damage, stereocilia, calcium waves, intercellular calcium signaling, organ of Corti, supporting cells, ATP, IP3 receptor, intracellular calcium stores, auditory sensory epithelium, hair cell death
- MeSH terms
- Adenosine Triphosphate, Fluorescent Antibody Technique, Hair Cells, Auditory, Humans, Organ of Corti, Sound, Inositol 1,4,5-Trisphosphate, Receptors, Purinergic P2, Calcium Signaling, Reverse Transcriptase Polymerase Chain Reaction
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