Effects of dietary weight loss on obstructive sleep apnea: a meta-analysis
Abstract
Purpose Clinical and epidemiologic investigations suggest a strong association between obesity and obstructive sleep apnea (OSA). The purpose of this study is to evaluate the currently available literature reporting on the effectiveness of dietary weight loss in treating OSA among obese patients.Methods Relevant studies were identified by computerized searches of PubMed, EMBASE, CINAHL, Web of Science, and The Cochrane Central Register of Controlled Trials through September 2011 as well as the reference lists of all obtained articles. Information on study design, patient characteristics, pre- and post-dietary weight loss measures of OSA and body mass index (BMI), and study quality was obtained. Data were extracted by two independent analysts. Weighted averages using a random-effects model are reported with 95 % confidence intervals.Results Nine articles representing 577 patients were selected. Dietary weight loss program resulted in a pooled mean BMI reduction of 4.8 kg/m(2) (95 % confidence interval [CI] 3.8-5.9). The random-effects pooled apnea hypopnea (AHI) indices at pre- and post-dietary intervention were 52.5 (range 10.0-91.0) and 28.3 events/h (range 5.4-64.5), respectively (p < 0.001). Compared to control, the weighted mean difference of AHI was decreased by -14.3 events/h (95 % CI -23.5 to -5.1; p = 0.002) in favor of the dietary weight loss programs.Conclusions Dietary weight loss programs are effective in reducing the severity of OSA but not adequate in relieving all respiratory events. Weight reduction programs should be considered as adjunct rather than curative therapy.
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Weight loss from behavioral or surgical interventions may improve and sometimes resolve sleep-disordered breathing.
“Together, this emerging body of literature suggests that weight loss achieved through behavioral or surgical interventions may be effective for improving and in some cases resolving SDB.”
From Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association (2016) · cites this paper as [159]
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- Authors
- Anandam, A., Akinnusi, M., Kufel, T., Porhomayon, J., & El-Solh, A. A.
- Affiliations
- University at Buffalo, State University of New York (US)
- VA Western New York Healthcare System (US)
- Buffalo VA Medical Center (US)
- Corresponding author
- El-Solh, Ali A.
- Venue
- Sleep and Breathing
- Published
- 2012-02-29
- Volume
- 17
- Issue
- 1
- Pages
- 227-234
- ISSN
- 1520-9512 (ISSN-L)
- 1522-1709
- OpenAlex
- W2060940284
- Cited by
- 95
- References
- 49
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 12 · 2012: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sleep And Breathing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- obstructive sleep apnea, dietary weight loss, obesity, body mass index reduction, apnea-hypopnea index, slimming program, adjunctive therapy
- MeSH terms
- Diet, Reducing, Follow-Up Studies, Humans, Prospective Studies, Weight Loss, Body Mass Index, Randomized Controlled Trials as Topic, Treatment Outcome, Sleep Apnea, Obstructive
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