Cited by 95Obstructive Sleep Apnea ResearchSleep and related disordersApelin-related biomedical research

Effects of dietary weight loss on obstructive sleep apnea: a meta-analysis

Anandam, Anil, Akinnusi, Morohunfolu, Kufel, Thomas, Porhomayon, Jahan, El-Solh, Ali A.·2013·Sleep and Breathing

Abstract

Purpose Clinical and epidemiologic investigations suggest a strong association between obesity and obstructive sleep apnea (OSA). The purpose of this study is to evaluate the currently available literature reporting on the effectiveness of dietary weight loss in treating OSA among obese patients.Methods Relevant studies were identified by computerized searches of PubMed, EMBASE, CINAHL, Web of Science, and The Cochrane Central Register of Controlled Trials through September 2011 as well as the reference lists of all obtained articles. Information on study design, patient characteristics, pre- and post-dietary weight loss measures of OSA and body mass index (BMI), and study quality was obtained. Data were extracted by two independent analysts. Weighted averages using a random-effects model are reported with 95 % confidence intervals.Results Nine articles representing 577 patients were selected. Dietary weight loss program resulted in a pooled mean BMI reduction of 4.8 kg/m(2) (95 % confidence interval [CI] 3.8-5.9). The random-effects pooled apnea hypopnea (AHI) indices at pre- and post-dietary intervention were 52.5 (range 10.0-91.0) and 28.3 events/h (range 5.4-64.5), respectively (p < 0.001). Compared to control, the weighted mean difference of AHI was decreased by -14.3 events/h (95 % CI -23.5 to -5.1; p = 0.002) in favor of the dietary weight loss programs.Conclusions Dietary weight loss programs are effective in reducing the severity of OSA but not adequate in relieving all respiratory events. Weight reduction programs should be considered as adjunct rather than curative therapy.

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Crossref · 10.1007/s11325-012-0677-3

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Authors
Anandam, A., Akinnusi, M., Kufel, T., Porhomayon, J., & El-Solh, A. A.
Affiliations
  • University at Buffalo, State University of New York (US)
  • VA Western New York Healthcare System (US)
  • Buffalo VA Medical Center (US)
Corresponding author
El-Solh, Ali A.
Venue
Sleep and Breathing
Published
2012-02-29
Volume
17
Issue
1
Pages
227-234
ISSN
  • 1520-9512 (ISSN-L)
  • 1522-1709
OpenAlex
W2060940284
Cited by
95
References
49
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 12 · 2012: 3
FWCI
1.05
Type
journal article
Language
en
Open access
closed
Locations
  • Sleep And Breathing (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
Keywords
obstructive sleep apnea, dietary weight loss, obesity, body mass index reduction, apnea-hypopnea index, slimming program, adjunctive therapy
MeSH terms
Diet, Reducing, Follow-Up Studies, Humans, Prospective Studies, Weight Loss, Body Mass Index, Randomized Controlled Trials as Topic, Treatment Outcome, Sleep Apnea, Obstructive

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