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Cited by 4Coffee research and impactsSexual function and dysfunction studiesMale Reproductive Health Studies

Association between caffeine intake and erectile dysfunction: a meta-analysis of cohort studies

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Karimi, Mehdi, Asbaghi, Omid, Kazemi, Kimia, Sedgi, Fatemeh Maleki, Soleimani, Ensiye, Moghadam, Hanieh Keikhay·2024·Journal of Health, Population and Nutrition
DOI 10.1186/s41043-024-00645-wPMC PMC11439322
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Abstract

Background: Erectile dysfunction (ED) is a common condition with various contributing factors, including lifestyle and dietary habits. Caffeine, a widely consumed stimulant, has been linked to multiple physiological effects on vascular function and hormonal balance that might influence sexual function. This meta-analysis aims to evaluate the association between caffeine intake and the risk of ED by analyzing data from cohort studies. Methods: A systematic search was conducted across PubMed, Web of Science, Scopus, and Embase databases, and a manual search was conducted on Google Scholar for studies on the relationship between caffeine intake and ED in adult men. The search included observational studies published up to April 1, 2024. Four cohort studies were included, and their data were extracted and analyzed by STATA version 18. Results: Four included cohort studies comprised 51,665 cohort members. The study population included adult males, on average, aged 18 to 80. The results indicate that there was no significant relationship between coffee consumption and the risk of ED (relative risk [RR] = 0.94, 95% CI: 0.86–1.03; p = 0.999). Conclusions: The current evidence suggests no significant relationship between caffeine intake and ED, but limited studies limit conclusions. Future research should focus on larger sample sizes, standardized outcome assessments, and different dosages and forms of caffeine consumption.

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  • Pooled data from two large meta-analyses found no causal association between caffeine intake and erectile dysfunction.

    “but pooled data from two large meta-analyses found no causal association.[41][42][43]”

    From A systematic appraisal of emerging alternative therapies in men’s health and wellness (2025) · cites this paper as [41]

    The Results (Caffeine and ED; page not provided) report no statistically significant association in a meta-analysis of four cohort studies. The Conclusion says the limited evidence does not permit robust conclusions and calls for further research to clarify causality. Thus, this source supports a lack of detected association, not a finding of no causal association. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Karimi, M., Asbaghi, O., Kazemi, K., Sedgi, F. M., Soleimani, E., & Moghadam, H. K.
Affiliations
  • Bogomolets National Medical University (UA)
  • Shahid Beheshti University of Medical Sciences (IR)
  • Urmia University (IR)
  • Tabriz University of Medical Sciences (IR)
  • Varastegan Institute for Medical Sciences (IR)
Corresponding author
  • Karimi, Mehdi
  • Asbaghi, Omid
  • Kazemi, Kimia
  • Sedgi, Fatemeh Maleki
  • Soleimani, Ensiye
  • Moghadam, Hanieh Keikhay
ORCID
Venue
Journal of Health, Population and Nutrition
Publisher
Springer Science and Business Media LLC
Published
2024-09-28
Volume
43
Issue
1
Pages
154-154
ISSN
  • 1606-0997 (ISSN-L)
  • 2072-1315
DOI
10.1186/s41043-024-00645-w
PMC
PMC11439322
OpenAlex
W4402941937
Cited by
4
References
6
Citations by year
2026: 2 · 2025: 2
FWCI
0.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Health Population and Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
Keywords
caffeine consumption, erectile dysfunction, coffee consumption, sexual function, vascular function, hormonal balance, men's health
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Caffeine, Coffee, Humans, Erectile Dysfunction, Male, Middle Aged, Risk Factors, Cohort Studies, Young Adult

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