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Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats
Abstract
Fipronil (FPN) is a phenylpyrazole insecticide, widely used for agricultural and veterinary activities. Early reports indicated that FIP organ toxicity is primarily mediated by the induction of oxidative stress. Both thymoquinone (TQ) and diallyl sulfide (DAS) are natural antioxidants with established health benefits. This study investigated the potential ameliorative effects of DAS and TQ against FPN-induced toxicity in rats. Thirty-two male Wistar rats (150-180 g) were randomized into four treatment groups, receiving (I) saline, (II) FPN (10 mg/kg bw), (III) FPN with DAS (200 mg/kg bw), and (IV) FPN with TQ (10 mg/kg bw). All treatments were administered once daily for 28 days. The results showed that compared to the control rats, FPN-treated rats had significantly increased (p < 0.05) serum levels of uric acid, urea, creatinine, cholesterol, aspartate transferase, alanine transferase, alkaline phosphatase, lactate dehydrogenase, and γ-glutamyl transferase. Moreover, FPN significantly reduced (p < 0.05) the serum levels of total proteins, albumin, and triglycerides. In addition, compared with the control group, FPN-treated rats had significantly elevated (p < 0.05) malondialdehyde and nitric oxide levels, as well as significantly reduced glutathione concentration and activities of glutathione peroxidase, superoxide dismutase, and catalase enzymes in the hepatic, renal, and brain tissues. Cotreatment with DAS or TQ significantly ameliorated (p < 0.05) the FPN-induced alterations in all the previously mentioned parameters with more frequent restoration of normal control ranges in the TQ group. In conclusion, both DAS and TQ alleviated the oxidative injury of FPN, probably by enhancing tissue antioxidant defenses.
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DAS exhibited potent antioxidant and cytoprotective activities, and these activities may be due to suppressing the enzymatic activity of cytochrome P450-2E1 and thereby reducing the generation of reactive oxygen and nitrogen species or by inducing the mRNA expression of Nrf2 and heme-oxygenase 1 enzyme.
“Interestingly, Abdel-Daim et al. [69] reported that DAS exhibited potent antioxidant and cytoprotective activities and these activities may be due to suppressing the enzymatic activity of cytochrome P450-2E1 and thereby reducing the generation of reactive oxygen and nitrogen species or by inducing the mRNA expression of Nrf2 and heme-oxygenase 1 enzyme.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [69]
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Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931
Protective effects of thymoquinone and diallyl sulphide against malathion-induced toxicity in rats
Abdel-Daim, M. M., Abushouk, A. I., Bungău, S. G., Bin-Jumah, M., El-kott, A. F., Shati, A. A., Aleya, L., & Alkahtani, S. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-07580-y · Cited by 49
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Metadata
- Authors
- Abdel-Daim, M. M., Shaheen, H. M., Abushouk, A. I., Toraih, E. A., Fawzy, M. S., Alansari, W. S., Aleya, L., & Bungau, S.
- Affiliations
- Damanhour University (EG)
- Ain Shams University (EG)
- Suez Canal University (EG)
- King Abdulaziz University (SA)
- Centre National de la Recherche Scientifique (FR)
- University of Oradea (RO)
- ORCID
- Venue
- Environmental Science and Pollution Research
- Published
- 2018-06-07
- Volume
- 25
- Issue
- 24
- Pages
- 23909-23916
- ISSN
- 0944-1344 (ISSN-L)
- 1614-7499
- OpenAlex
- W2806003736
- Cited by
- 65
- References
- 70
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 5
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Environmental Science and Pollution Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- fipronil, thymoquinone, diallyl sulfide, oxidative stress, insecticide toxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, antioxidant enzymes, glutathione, malondialdehyde, nitric oxide, phenylpyrazole insecticides, hepatoprotection, renal protection, neuroprotection
- MeSH terms
- Allyl Compounds, Animals, Antioxidants, Brain, Enzymes, Glutathione, Insecticides, Kidney, Liver, Male, Malondialdehyde, Nitric Oxide, Pyrazoles, Sulfides, Lipid Peroxidation, Benzoquinones, Rats, Wistar, Oxidative Stress, Protective Agents
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