NIA workshop on senescence in brain aging and Alzheimer's disease and its related dementias

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

Tau protein aggregation is associated with cellular senescence in the brain

Musi, N., Valentine, J. M., Sickora, K. R., Baeuerle, E., Thompson, C. S., Shen, Q., & Orr, M. E. (2018) · Aging Cell · doi:10.1111/acel.12840 · Cited by 595 · see citing works

Senolytic therapies for healthy longevity.

van Deursen, J. M. (2019) · Science · doi:10.1126/science.aaw1299 · Cited by 237 · see citing works

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age

Mehdipour, M., Etienne, J., Chen, C., Gathwala, R., Rehman, M., Kato, C., Liu, C., Liu, Y., Zuo, Y., Conboy, M. J., et al. (2019) · Aging · doi:10.18632/aging.102148 · Cited by 42 · see citing works

Unknown fates of (brain) oxidation or UFO: Close encounters with neuronal senescence

Walton, C. C., & Andersen, J. K. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.012 · Cited by 26 · see citing works

Increase in blood–brain barrier leakage in healthy, older adults

Verheggen, I. C. M., de Jong, J. J. A., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Palm, W. M., Postma, A. A., Jansen, J. F. A., Verhey, F. R. J., & Backes, W. H. (2020) · GeroScience · doi:10.1007/s11357-020-00211-2 · Cited by 205 · see citing works

Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial

Gonzales, M. M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., & Orr, M. E. (2022) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.62 · Cited by 203 · see citing works

Therapeutic targeting of senescent cells in the CNS

Rießland, M., Ximerakis, M., Jarjour, A. A., Zhang, B., & Orr, M. E. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01033-z · Cited by 74 · see citing works

Geroscience and pathology: a new frontier in understanding age-related diseases

Fekete, M., Major, D., Fehér, Á., Fazekas‐Pongor, V., & Lehoczki, A. (2024) · Pathology & Oncology Research · doi:10.3389/pore.2024.1611623 · Cited by 64 · see citing works

High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture

Hou, J., Jeon, B.-M., Baek, J.-I., Yun, Y. J., Kim, D., Chang, B., Kim, S.-Y., & Kim, S. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.04.002 · Cited by 56 · see citing works

Residual Disease in Glioma Recurrence: A Dangerous Liaison with Senescence

Putavet, D. A., & de Keizer, P. L. J. (2021) · Cancers · doi:10.3390/cancers13071560 · Cited by 39 · see citing works

A geroscience motivated approach to treat Alzheimer’s disease: Senolytics move to clinical trials

Gonzales, M. M., Krishnamurthy, S., Garbarino, V. R., Daeihagh, A. S., Gillispie, G. J., Deep, G., Craft, S., & Orr, M. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111589 · Cited by 37 · see citing works

Brain cellular senescence in mouse models of Alzheimer’s disease

Dorigatti, A. O., Riordan, R., Yu, Z., Ross, G., Wang, R., Reynolds-Lallement, N. C., Magnusson, K. R., Galván, V., & Pérez, V. (2022) · GeroScience · doi:10.1007/s11357-022-00531-5 · Cited by 32 · see citing works

Connecting the dots: Neuronal senescence, stress granules, and neurodegeneration

Ma, Y., & Farny, N. G. (2023) · Gene · doi:10.1016/j.gene.2023.147437 · Cited by 30 · see citing works

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29 · see citing works

Senescence-related genes as prognostic indicators in breast cancer survival

Ungvari, Z. I., Ungvari, A., Fekete, M., Kiss, C., & Győrffy, B. (2024) · GeroScience · doi:10.1007/s11357-024-01384-w · Cited by 14 · see citing works

Neuronal Rubicon Represses Extracellular APP/Amyloid β Deposition in Alzheimer’s Disease

Espinoza, S., Grünenwald, F., Gómez, W., García, F., Abarzúa-Catalán, L., Oyarce-Pezoa, S., Hernandez, M. F., Cortés, B. I., Uhrig, M., Ponce, D. P., et al. (2022) · Cells · doi:10.3390/cells11121860 · Cited by 8 · see citing works

Senotherapeutics: Emerging pharmacological strategies to target cellular senescence

Nagy, D., Brunner, E., Ekambaram, S., Nagaraja, R. Y., Kordestan, K. V., Patai, R., Kristóf, R., Nagykaldi, M., Chandragiri, S. S., Shanmugarama, S., et al. (2026) · Advances in Translational Research · doi:10.1556/1661.2026.00015 · Cited by 1 · see citing works

Paparan Pestisida Menginduksi Senesen Dini Pada Mesenchymal Stem Cell In Vitro

Adaninggar, A., Oktavya, G., Putri, R. R. R. A. D., Aprilianti, S. H. U., & Nuriliani, A. (2024) · Journal of Biota · doi:10.24002/biota.v9i1.6340 · Cited by 1 · see citing works

Imaging blood-brain barrier function in aging

Verheggen, I. C. M. (2021) · doi:10.26481/dis.20210601iv

Novel cell markers with altered expression in brain aging and Alzheimer's disease: A review

Alobu, E. J., Uchewa, O. O., & Ibegbu, A. O. (2026) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2026.08.010

Cellular senescence and the aging brain

Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works

Cellular senescence in brain aging and neurodegeneration: from molecular mechanisms to translational opportunities

Cantero‐Fortiz, Y., Butler, C., Montalbán, X., & Boada, M. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1805691 · Cited by 5 · see citing works

Cellular senescence in brain aging

Sikora, E., Bielak-Zmijewska, A., Dudkowska, M., Krzystyniak, A., Mosieniak, G., Wesierska, M., & Wlodarczyk, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646924 · Cited by 304 · see citing works

Cellular senescence at the crossroads of inflammation and Alzheimer's disease

Guerrero, A., De Strooper, B., & Arancibia-Cárcamo, I. L. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.06.007 · Cited by 236 · see citing works

Decoding senescent drivers in Alzheimer's disease: From bench to bedside

Zhou, R., Lin, X., Liao, Z., Lin, J., Zheng, R., Ni, H., Liu, W., Feng, Z., He, Q., Lin, X., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102978 · Cited by 4 · see citing works