Are there roles for brain cell senescence in aging and neurodegenerative disorders?

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 2× · see citing works

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

Bannister, A. J., Zegerman, P., Partridge, J. F., Miska, E. A., Thomas, J. O., Allshire, R. C., & Kouzarides, T. (2001) · Nature · doi:10.1038/35065138 · Cited by 2,903 · see citing works

The role of senescent cells in ageing

van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623 · see citing works

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Acosta, J. C., Banito, A., Wuestefeld, T., Georgilis, A., Janich, P., Morton, J. P., Athineos, D., Kang, T.-W., Lasitschka, F., Andrulis, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2784 · Cited by 2,278 · cited 1× · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

The role of autophagy in neurodegenerative disease

Nixon, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3232 · Cited by 2,059 · see citing works

The essence of senescence: Figure 1.

Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works

Gene regulation and DNA damage in the ageing human brain

Lu, T., Pan, Y., Kao, S.-Y., Li, C., Kohane, I., Chan, J., & Yankner, B. A. (2004) · Nature · doi:10.1038/nature02661 · Cited by 1,874 · see citing works

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works

Senescence-associated β-galactosidase is lysosomal β-galactosidase.

Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444 · see citing works

Programmed cell senescence during mammalian embryonic development

Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428 · see citing works

p38 MAP-Kinases pathway regulation, function and role in human diseases

Cuenda, A., & Rousseau, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.010 · Cited by 1,397 · see citing works

Mitochondrial abnormalities in Alzheimer's disease

Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works

Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., & Smith, J. R. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1063 · Cited by 1,351 · see citing works

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works

Chronic stress and age-related increases in the proinflammatory cytokine IL-6.

Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,220 · see citing works

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Lee, J.-H., Yu, W. H., Kumar, A., Lee, S., Mohan, P. S., Peterhoff, C. M., Wolfe, D. M., Martinez-Vicente, M., Massey, A. C., Sovak, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.05.008 · Cited by 1,212 · see citing works

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186 · see citing works

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · see citing works

Autophagy mediates the mitotic senescence transition

Young, A. R. J., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J. F. J., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F. M., et al. (2009) · Genes & Development · doi:10.1101/gad.519709 · Cited by 1,078 · see citing works

Lamin B1 loss is a senescence-associated biomarker

Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works

p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype

Freund, A., Patil, C. K., & Campisi, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.69 · Cited by 1,039 · cited 4× · see citing works

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

Alcorta, D. A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., & Barrett, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13742 · Cited by 1,008 · see citing works

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B., & Mucke, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10061 · Cited by 1,006 · see citing works

Autophagy gone awry in neurodegenerative diseases

Wong, E. S. P., & Cuervo, A. M. (2010) · Nature Neuroscience · doi:10.1038/nn.2575 · Cited by 883 · see citing works

Cellular senescence and its effector programs

Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855 · see citing works

Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

Blum-Degena, D., Müller, T., Kuhn, W., Gerlach, M., Przuntek, H., & Riederer, P. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12192-7 · Cited by 801 · see citing works

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology · doi:10.1038/ncb1095 · Cited by 790 · see citing works

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757 · see citing works

Cellular Senescence

Sherr, C. J., & DePinho, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00046-5 · Cited by 745 · see citing works

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works

Oxidative DNA damage and senescence of human diploid fibroblast cells.

Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., & Ames, B. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4337 · Cited by 720 · see citing works

Dystrophic microglia in the aging human brain

Streit, W. J., Sammons, N. W., Kuhns, A. J., & Sparks, D. L. (2004) · Glia · doi:10.1002/glia.10319 · Cited by 705 · see citing works

Developmental genetics of vertebrate glial–cell specification

Rowitch, D., & Kriegstein, A. (2010) · Nature · doi:10.1038/nature09611 · Cited by 685 · see citing works

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

Lipinski, M. M., Zheng, B., Lu, T., Yan, Z., Py, B. F., Ng, A., Xavier, R. J., Li, C., Yankner, B. A., Scherzer, C. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009485107 · Cited by 680 · see citing works

Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response

Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00870.x · Cited by 598 · see citing works

Astrocyte Senescence as a Component of Alzheimer’s Disease

Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586 · see citing works

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway

Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563 · see citing works

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

Shah, P. P., Donahue, G., Otte, G. L., Capell, B. C., Nelson, D. M., Cao, K., Aggarwala, V., Cruickshanks, H. A., Rai, T. S., McBryan, T., et al. (2013) · Genes & Development · doi:10.1101/gad.223834.113 · Cited by 550 · see citing works

The role of nuclear lamin B1 in cell proliferation and senescence

Shimi, T., Butin-Israeli, V., Adam, S. A., Hamanaka, R. B., Goldman, A. E., Lucas, C. A., Shumaker, D. K., Kosak, S. T., Chandel, N. S., & Goldman, R. D. (2011) · Genes & Development · doi:10.1101/gad.179515.111 · Cited by 547 · see citing works

Tau promotes neurodegeneration through global chromatin relaxation

Frost, B., Hemberg, M., Lewis, J., & Feany, M. B. (2014) · Nature Neuroscience · doi:10.1038/nn.3639 · Cited by 519 · cited 2× · see citing works

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer’s disease

Yang, Y., Mufson, E. J., & Herrup, K. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02557.2003 · Cited by 483 · see citing works

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., & Berger, M. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80737-n · Cited by 483 · see citing works

Role of Ceramide in Cellular Senescence

Venable, M. E., Lee, J. Y., Smyth, M. J., Bielawska, A. E., & Obeid, L. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30701 · Cited by 468 · see citing works

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

De Cecco, M., Criscione, S. W., Peckham, E. J., Hillenmeyer, S., Hamm, E. A., Manivannan, J., Peterson, A. L., Kreiling, J. A., Neretti, N., & Sedivy, J. M. (2013) · Aging Cell · doi:10.1111/acel.12047 · Cited by 459 · see citing works

A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

Coppé, J.-P., Patil, C. K., Rodier, F., Krtolica, A., Beauséjour, C. M., Parrinello, S., Hodgson, J. G., Chin, K., Desprez, P.-Y., & Campisi, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009188 · Cited by 455 · see citing works

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans

Boehm, M., & Slack, F. J. (2005) · Science · doi:10.1126/science.1115596 · Cited by 449 · see citing works

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

Ramirez, R. D., Morales, C. P., Herbert, B.-S., Rohde, J. M., Passons, C., Shay, J. W., & Wright, W. E. (2001) · Genes & Development · doi:10.1101/gad.859201 · Cited by 444 · cited 2× · see citing works

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

Wang, Q., Walsh, D. M., Rowan, M. J., Selkoe, D. J., & Anwyl, R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1633-03.2004 · Cited by 437 · see citing works

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

Stephan, A. H., Madison, D. V., Mateos, J. M., Fraser, D. A., Lovelett, E. A., Coutellier, L., Kim, L., Tsai, H.-H., Huang, E. J., Rowitch, D. H., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1333-13.2013 · Cited by 423 · see citing works

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

McShea, A., Harris, P. L. R., Webster, K. R., Wahl, A. F., & Smith, M. A. (1997) · Europe PMC (PubMed Central) · Cited by 422 · see citing works

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

Town, T., Laouar, Y., Pittenger, C., Mori, T., Szekely, C. A., Tan, J., Duman, R. S., & Flavell, R. A. (2008) · Nature Medicine · doi:10.1038/nm1781 · Cited by 422 · see citing works

Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions

Chu, Y., Dodiya, H. B., Aebischer, P., Olanow, C. W., & Kordower, J. H. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.023 · Cited by 420 · see citing works

Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease

Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., & Mucke, L. (1997) · Nature · doi:10.1038/39321 · Cited by 417 · see citing works

Molecular dissection of formation of senescence-associated heterochromatin foci

Zhang, R., Chen, W., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02019-06 · Cited by 415 · see citing works

Microglial senescence: does the brain's immune system have an expiration date?

Streit, W. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.001 · Cited by 397 · see citing works

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

Liu, N., Landreh, M., Cao, K., Abe, M., Hendriks, G., Kennerdell, J. R., Zhu, Y., Wang, L., & Bonini, N. M. (2012) · Nature · doi:10.1038/nature10810 · Cited by 394 · see citing works

Parkin and PINK1: much more than mitophagy

Scarffe, L. A., Stevens, D. A., Dawson, V. L., & Dawson, T. M. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.004 · Cited by 392 · see citing works

Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway

Iwasa, H., Han, J., & Ishikawa, F. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00620.x · Cited by 388 · see citing works

Epigenetic changes in Alzheimer's disease: Decrements in DNA methylation

Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C. M., Coleman, P. D., & Rogers, J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.12.005 · Cited by 386 · see citing works

Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage

Kruman, I. I., Wersto, R. P., Cardozo‐Pelaez, F., Smilenov, L. B., Chan, S. L., Chrest, F. J., Emokpae, R., Gorospe, M., & Mattson, M. P. (2004) · Neuron · doi:10.1016/s0896-6273(04)00017-0 · Cited by 365 · see citing works

Activation of transposable elements during aging and neuronal decline in Drosophila

Li, W., Prazak, L., Chatterjee, N., Grüninger, S., Krug, L., Theodorou, D., & Dubnau, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3368 · Cited by 346 · see citing works

Microglia in the Aging Brain

Conde, J. R., & Streit, W. J. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000202887.22082.63 · Cited by 344 · see citing works

Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases

Mattson, M. P., Pedersen, W. A., Duan, W., Culmsee, C., & Camandola, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07824.x · Cited by 343 · see citing works

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress–induced death of motor neurons in amyotrophic lateral sclerosis

Cutler, R. G., Pedersen, W. A., Camandola, S., Rothstein, J. D., & Mattson, M. P. (2002) · Annals of Neurology · doi:10.1002/ana.10312 · Cited by 325 · see citing works

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

Zhao, L., Ma, Q.-L., Calon, F., Harris-White, M. E., Yang, F., Lim, G. P., Morihara, T., Ubeda, O. J., Ambegaokar, S., Hansen, J. E., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1630 · Cited by 317 · see citing works

Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation

Chandra, T., Kirschner, K., Thuret, J.-Y., Pope, B. D., Ryba, T., Newman, S., Ahmed, K., Samarajiwa, S. A., Salama, R., Carroll, T., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.010 · Cited by 308 · see citing works

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

Lee, S., Jeong, S.-Y., Lim, W.-C., Kim, S., Park, Y.-Y., Sun, X., Youle, R. J., & Cho, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700679200 · Cited by 298 · see citing works

Abnormal Mitochondrial Morphology in Sporadic Parkinson's and Alzheimer's Disease Cybrid Cell Lines

Trimmer, P. A., Swerdlow, R. H., Parks, J. K., Keeney, P. M., Bennett, J. P., Miller, S. W., Davis, R. E., & Parker, W. D. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7333 · Cited by 296 · see citing works

Activation of c-Jun N-Terminal Kinase and p38 in an Alzheimer's Disease Model Is Associated with Amyloid Deposition

Savage, M. J., Lin, Y.-G., Ciallella, J. R., Flood, D. G., & Scott, R. W. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03376.2002 · Cited by 291 · see citing works

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16^ink4a

Kosar, M., Bartkova, J., Hubackova, S., Hodny, Z., Lukas, J., & Bartek, J. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14707 · Cited by 283 · see citing works

Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

Mori, M. A., Raghavan, P., Thomou, T., Boucher, J., Robida-Stubbs, S., Macotela, Y., Russell, S. J., Kirkland, J. L., Blackwell, T. K., & Kahn, C. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.017 · Cited by 279 · see citing works

Formation of elongated giant mitochondria in DFO‐induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1

Yoon, Y., Yoon, D., Lim, I. K., Yoon, S., Chung, H., Rojo, M., Malka, F., Jou, M., Martinou, J., & Yoon, G. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20753 · Cited by 275 · see citing works

Evidence That Aging And Amyloid Promote Microglial Cell Senescence

Flanary, B. E., Sammons, N. W., Nguyen, C., Walker, D., & Streit, W. J. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.9096 · Cited by 272 · see citing works

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

Haughey, N. J., Bandaru, V. V. R., Bae, M. H., & Mattson, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.003 · Cited by 271 · see citing works

Long‐term culture of mouse cortical neurons as a model for neuronal development, aging, and death

Lesuisse, C., & Martin, L. J. (2002) · Journal of Neurobiology · doi:10.1002/neu.10037 · Cited by 263 · see citing works

Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1

Mai, S., Klinkenberg, M., Auburger, G., Bereiter-Hahn, J., & Jendrach, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.059246 · Cited by 256 · see citing works

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

Kang, H. T., Lee, K. B., Kim, S. Y., Choi, H. R., & Park, S. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023367 · Cited by 254 · see citing works

Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease

Sheehan, J. P., Swerdlow, R. H., Miller, S. W., Davis, R. E., Parks, J. K., Parker, W. D., & Tuttle, J. B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04612.1997 · Cited by 249 · see citing works

Metabolic analysis of senescent human fibroblasts reveals a role for AMP in cellular senescence

Zwerschke, W., Mazurek, S., Stöckl, P., Hütter, E., EIGENBRODT, E., & Jansen‐Dürr, P. (2003) · Biochemical Journal · doi:10.1042/bj20030816 · Cited by 248 · see citing works

Ageing and telomeres: a study into organ- and gender-specific telomere shortening

Cherif, H. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg208 · Cited by 246 · see citing works

Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein

Wood, J. A., Wood, P. L., Ryan, R., Graff-Radford, N. R., Pilapil, C., Robitaille, Y., & Quirion, R. (1993) · Brain Research · doi:10.1016/0006-8993(93)91327-o · Cited by 244 · see citing works

Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease

Mattson, M. P., Barger, S. W., Furukawa, K., Bruce‐Keller, A. J., Wyss‐Coray, T., Mark, R. J., & Mucke, L. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00014-8 · Cited by 243 · see citing works

Systemic inflammatory cells fight off neurodegenerative disease

Schwartz, M., & Shechter, R. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.71 · Cited by 240 · see citing works

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

Pribluda, A., Elyada, E., Wiener, Z., Hamza, H., Goldstein, R. E., Biton, M., Burstain, I., Morgenstern, Y., Brachya, G., Billauer, H., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.005 · Cited by 239 · see citing works

Transforming Growth Factor-Beta Induces Senescence in Hepatocellular Carcinoma Cells and Inhibits Tumor Growth†,‡

Şentürk, Ş., Mumcuoğlu, M., Gürsoy-Yüzügüllü, Ö., Cingoz, B., Akçalı, K. C., & Öztürk, M. (2010) · Hepatology · doi:10.1002/hep.23769 · Cited by 238 · see citing works

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

Tang, D. G., Tokumoto, Y. M., Apperly, J. A., Lloyd, A. C., & RAFF, M. C. (2001) · Science · doi:10.1126/science.1056780 · Cited by 228 · see citing works

Alterations in microRNA expression in stress-induced cellular senescence

Li, G., Luna, C., Qiu, J., Epstein, D. L., & González, P. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.09.002 · Cited by 220 · see citing works

P38 MAP kinase is activated at early stages in Alzheimer's disease brain

Sun, A. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00180-8 · Cited by 219 · see citing works

Cell cycle arrest is not senescence

Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100281 · Cited by 217 · see citing works

Increased Sensitivity to Mitochondrial Toxin-Induced Apoptosis in Neural Cells Expressing Mutant Presenilin-1 Is Linked to Perturbed Calcium Homeostasis and Enhanced Oxyradical Production

Keller, J. N., Guo, Q., Holtsberg, F. W., Bruce‐Keller, A. J., & Mattson, M. P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04439.1998 · Cited by 214 · see citing works

Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients

Huell, M., Strauss, S., Volk, B., Berger, M., & Bauer, J. (1995) · Acta Neuropathologica · doi:10.1007/bf00571510 · Cited by 214 · see citing works

Growth and aging: a common molecular mechanism

Blagosklonny, M. V., & Hall, M. N. (2009) · Aging · doi:10.18632/aging.100040 · Cited by 212 · see citing works

Genetics of Parkinson's disease – state of the art, 2013

Bonifati, V. (2013) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(13)70009-9 · Cited by 209 · see citing works

Parkinson’s disease‐associated DJ‐1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

Wang, X., Petrie, T. G., Liu, Y., Liu, J., Fujioka, H., & Zhu, X. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07734.x · Cited by 206 · see citing works

Stress-induced senescence in human and rodent astrocytes

Bitto, A., Sell, C., Crowe, E., Lorenzini, A., Malaguti, M., Hrelia, S., & Torres, C. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.06.021 · Cited by 204 · see citing works

Cytokine Gene Expression as a Function of the Clinical Progression of Alzheimer Disease Dementia

Luterman, J. D., Haroutunian, V., Yemul, S., Ho, L., Purohit, D., Aisen, P. S., Mohs, R., & Pasinetti, G. M. (2000) · Archives of Neurology · doi:10.1001/archneur.57.8.1153 · Cited by 192 · see citing works

MicroRNAs and neurodegeneration: role and impact

Abe, M., & Bonini, N. M. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.013 · Cited by 190 · see citing works

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

Mattson, M. P., & Goodman, Y. (1995) · Brain Research · doi:10.1016/0006-8993(95)00148-j · Cited by 188 · see citing works

Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis

Ferrón, S. R., Marqués-Torrejón, M. Á., Mira, H., Flores, I., Taylor, K., Blasco, M. A., & Fariñas, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3836-09.2009 · Cited by 179 · see citing works

Lysosomal storage diseases as disorders of autophagy

Settembre, C., Fraldi, A., Rubinsztein, D. C., & Ballabio, A. (2008) · Autophagy · doi:10.4161/auto.5227 · Cited by 172 · see citing works

Sphingomyelin and ceramide as regulators of development and lifespan

Cutler, R. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00246-9 · Cited by 171 · see citing works

Astrocytes aged <i>in vitro</i> show a decreased neuroprotective capacity

Pertusa, M., García‐Matas, S., Rodríguez‐Farré, E., Sanfeliu, C., & Cristòfol, R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04369.x · Cited by 168 · see citing works

Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes

Flanary, B. E., & Streit, W. J. (2004) · Glia · doi:10.1002/glia.10301 · Cited by 167 · see citing works

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (2001) · Journal of Alzheimer's Disease · doi:10.3233/jad-2001-3107 · Cited by 165 · see citing works

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

Gire, V., & Wynford-Thomas, D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1611 · Cited by 161 · see citing works

Telomere shortening in neurological disorders: an abundance of unanswered questions

Eitan, E., Hutchison, E. R., & Mattson, M. P. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.02.010 · Cited by 158 · see citing works

Genome‐wide miRNA signatures of human longevity

Elsharawy, A., Keller, A., Flachsbart, F., Wendschlag, A., Jacobs, G., Kefer, N., Brefort, T., Leidinger, P., Backes, C., Meese, E., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00824.x · Cited by 156 · see citing works

Increased p53 Protein Associated with Aging in Human Diploid Fibroblasts

Kulju, K. S., & Lehman, J. M. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1095 · Cited by 155 · see citing works

Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells

Ferrón, S., Mira, H., Franco, S., Cano-Jaimez, M., Bellmunt, E., Ramírez, C., Fariñas, I., & Blasco, M. A. (2004) · Development · doi:10.1242/dev.01215 · Cited by 152 · see citing works

Amyloid-β1–42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2

He, N., Jin, W.-L., Lok, K.-H., Wang, Y., Yin, M., & Wang, Z.-J. (2013) · Cell Death &amp; Disease · doi:10.1038/cddis.2013.437 · Cited by 151 · see citing works

Altered Calcium Homeostasis in Cells Transformed by Mitochondria from Individuals with Parkinson's Disease

Sheehan, J. P., Swerdlow, R. H., Parker, W. D., Miller, S. W., Davis, R. E., & Tuttle, J. B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68031221.x · Cited by 151 · see citing works

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence

Larsson, L. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.10.005 · Cited by 147 · see citing works

Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective

Tăcutu, R., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2011) · Aging · doi:10.18632/aging.100413 · Cited by 143 · see citing works

Identification of subpopulations in mesenchymal stem cell-like cultures from human umbilical cord

Majore, I., Moretti, P., Hass, R., & Kasper, C. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-6 · Cited by 142 · see citing works

MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways

Hu, Z., Klein, J. D., Mitch, W. E., Zhang, L., Martínez, I., & Wang, X. H. (2014) · Aging · doi:10.18632/aging.100643 · Cited by 138 · see citing works

The effects of aging, injury and disease on microglial function: a case for cellular senescence

Miller, K. R., & Streit, W. J. (2007) · Neuron Glia Biology · doi:10.1017/s1740925x08000136 · Cited by 134 · see citing works

DNA Synthesis and Neuronal Apoptosis Caused by Familial Alzheimer Disease Mutants of the Amyloid Precursor Protein Are Mediated by the p21 Activated Kinase PAK3

McPhie, D. L., Coopersmith, R., Hines-Peralta, A. U., Chen, Y., Ivins, K. J., Manly, S. P., Kozlowski, M. R., Neve, K. A., & Neve, R. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06914.2003 · Cited by 130 · see citing works

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

Geng, Y.-Q., Guan, J.-T., Xu, X.-H., & Fu, Y.-C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.011 · Cited by 129 · see citing works

Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress

Sitte, N., Merker, K., Grune, T., & von Zglinicki, T. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00253-9 · Cited by 127 · see citing works

Independent induction of senescence by p16INK4a and p21CIP1 in spontaneously immortalized human fibroblasts.

Vogt, M., Haggblom, C., Yeargin, J., Christiansen-Weber, T. A., & Haas, M. (1998) · PubMed · Cited by 124 · see citing works

Stepwise up‐regulation of MicroRNA expression levels from replicating to reversible and irreversible growth arrest states in WI‐38 human fibroblasts

Maes, O. C., Sarojini, H., & Wang, E. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21834 · Cited by 124 · see citing works

Regulation of two E2F-related genes in presenescent and senescent human fibroblasts.

Dimri, G. P., Hara, E., & Campisi, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33990-x · Cited by 122 · see citing works

Expression Patterns of Retinoblastoma Protein in Parkinson Disease

Jordan-Sciutto, K. L., Dorsey, R., Chalovich, E. M., Hammond, R. R., & Achim, C. L. (2003) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1093/jnen/62.1.68 · Cited by 121 · see citing works

Methylation and acetylation in nervous system development and neurodegenerative disorders

Mattson, M. P. (2003) · Ageing Research Reviews · doi:10.1016/s1568-1637(03)00013-8 · Cited by 119 · see citing works

Protein oxidation and degradation during postmitotic senescence

Grune, T., Merker, K., Jung, T., Sitte, N., & Davies, K. J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.009 · Cited by 117 · see citing works

Glucocorticoids induce long-lasting effects in neural stem cells resulting in senescence-related alterations

Bose, R., Moors, M., Tofighi, R., Cascante, A., Hermanson, O., & Ceccatelli, S. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.60 · Cited by 110 · see citing works

Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons

Raza, M., Deshpande, L. S., Blair, R. E., Carter, D. S., Sombati, S., & DeLorenzo, R. J. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.005 · Cited by 109 · see citing works

Alzheimer’s as a metabolic disease

Demetrius, L., & Driver, J. A. (2013) · Biogerontology · doi:10.1007/s10522-013-9479-7 · Cited by 108 · see citing works

Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a

Lüth, H. J., Holzer, M., Gertz, H.-J., & Arendt, T. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02178-2 · Cited by 105 · see citing works

Centenarians, but not octogenarians, up-regulate the expression of microRNAs

Serna, E., Gambini, J., Borrás, C., Abdelaziz, K. M., Belenguer‐Varea, Á., Sanchis, P., Avellana, J. A., Rodríguez‐Mañas, L., & Viña, J. (2012) · Scientific Reports · doi:10.1038/srep00961 · Cited by 101 · see citing works

Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson's disease

van Dijk, K. D., Persichetti, E., Chiasserini, D., Eusebi, P., Beccari, T., Calabresi, P., Berendse, H. W., Parnetti, L., & van de Berg, W. D. J. (2013) · Movement Disorders · doi:10.1002/mds.25495 · Cited by 101 · see citing works

Why do Neurons Enter the Cell Cycle?

Kruman, I. I. (2004) · Cell Cycle · doi:10.4161/cc.3.6.901 · Cited by 99 · see citing works

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer’s and other neurodegenerative diseases

Golde, T. E., & Miller, V. M. (2009) · Alzheimer's Research &amp; Therapy · doi:10.1186/alzrt5 · Cited by 98 · see citing works

Esophageal cancer-related gene 4 is a secreted inducer of cell senescence expressed by aged CNS precursor cells

Kujuro, Y., Suzuki, N., & Kondo, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911446107 · Cited by 94 · see citing works

Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein.

Medrano, E. E., Im, S., Yang, F., & ABDEL‐MALEK, Z. A. (1995) · PubMed · Cited by 92 · see citing works

TGF-β signaling engages an ATM-CHK2-p53–independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

Cipriano, R., Kan, C. E., Graham, J., Danielpour, D., Stampfer, M., & Jackson, M. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015022108 · Cited by 92 · see citing works

Increased organization of cytoskeleton accompanying the aging of human fibroblasts in vitro*1

Wang, E. (1984) · Experimental Cell Research · doi:10.1016/0014-4827(84)90679-7 · Cited by 92 · see citing works

Distribution of the mRNA encoding the four dopamine D1 receptor subtypes in the brain of the european eel (Anguilla anguilla): Comparative approach to the function of D1 receptors in vertebrates

Kapsimali, M., Vidal, B., González, A., Dufour, S., & Vernier, P. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000410)419:3 · Cited by 91 · see citing works

Effect of aging on the microglial response to peripheral nerve injury

Conde, J. R., & Streit, W. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.07.012 · Cited by 86 · see citing works

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

Belrose, J. C., Xie, Y., Gierszewski, L. J., MacDonald, J. F., & Jackson, M. F. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-11 · Cited by 86 · see citing works

Secreted β-amyloid precursor protein activates microglia via JNK and p38-MAPK

Bodles, A. M., & Barger, S. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.022 · Cited by 82 · see citing works

Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis

Ranganathan, S., Scudiere, S. C., & Bowser, R. P. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3403 · Cited by 76 · see citing works

Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes

Lin, D., Wu, J., Holstein, D. M., Upadhyay, G., Rourk, W., Muller, E., & Lechleiter, J. D. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.11.004 · Cited by 76 · see citing works

DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization

Micco, R. D., Cicalese, A., Fumagalli, M., Dobreva, M., Verrecchia, A., Pelicci, P. G., & di Fagagna, F. D. (2008) · Cell Cycle · doi:10.4161/cc.7.22.7152 · Cited by 76 · see citing works

The NetAge database: a compendium of networks for longevity, age-related diseases and associated processes

Tăcutu, R., Budovsky, A., & Fraifeld, V. E. (2010) · Biogerontology · doi:10.1007/s10522-010-9265-8 · Cited by 76 · see citing works

ALTERED CHROMATIN CONFORMATION IN ALZHEIMER'S DISEASE

Crapper, D. R., Quittkat, S., & Boni, U. D. (1979) · Brain · doi:10.1093/brain/102.3.483 · Cited by 76 · see citing works

Phenotypic and functional changes in glial cells as a function of age

Yu, W. H., Go, L., Guinn, B., Fraser, P. E., Westaway, D. A., & McLaurin, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00258-5 · Cited by 75 · see citing works

Age‐Dependent Changes in Calcium Currents and Calcium Homeostasis in Mammalian Neuronsa

Verkhratsky, A., Shmigol, A., Kirischuk, S., Pronchuk, N., & Kostyuk, P. G. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44423.x · Cited by 71 · see citing works

SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons

Panossian, L. A., Fenik, P., Zhu, Y., Zhan, G., McBurney, M. W., & Veasey, S. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5166-10.2011 · Cited by 70 · see citing works

Markers of cellular senescence.

Carnero, A. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-239-1_4 · Cited by 68 · see citing works

Why do neurons enter the cell cycle?

Kruman (2004) · PubMed · Cited by 67 · see citing works

A P53-dependent, telomere-independent proliferative life span barrier in human astrocytes consistent with the molecular genetics of glioma development.

Evans, R., Wyllie, F. S., Wynford‐Thomas, D., Kipling, D., & Jones, C. J. (2003) · PubMed · Cited by 66 · see citing works

Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts

Höhn, A., Sittig, A., Jung, T., Grimm, S., & Grune, T. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.591 · Cited by 64 · see citing works

IL-6-mediated events in Alzheimer's disease pathology

Bauer, J., Strauss, S., Volk, B., & Berger, T. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90148-m · Cited by 62 · see citing works

Developmental stage of oligodendrocytes determines their response to activated microglia in vitro

Miller, B. A., Gregoriades, J. M. C., Tovar, C. A., Ferguson, A. R., Bresnahan, J. C., & Beattie, M. S. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-28 · Cited by 62 · see citing works

Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging

Dong, W., Cheng, S., Huang, F. P., Fan, W., Chen, Y., Shi, H., & He, H. (2011) · Medical Science Monitor · doi:10.12659/msm.881706 · Cited by 58 · see citing works

Comparison of global DNA methylation profiles in replicative versus premature senescence.

Zhang, W., Ji, W.-D., Yang, J.-P., Yang, L.-Q., Chen, W., & Zhuang, Z.-X. (2008) · Life Science · doi:10.1016/j.lfs.2008.07.015 · Cited by 57 · see citing works

Golgi study of the mouse striatum: Age‐related dendritic changes in different neuronal populations

Rafols, J. A., Cheng, H. W., & McNeill, T. H. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902790205 · Cited by 56 · see citing works

Paired helical filaments and the cytoplasmic-nuclear interface in Alzheimer's disease

Metuzals, J., Robitaille, Y., Houghton, S., Gauthier, S. G., & Leblanc, R. (1988) · Journal of Neurocytology · doi:10.1007/bf01216709 · Cited by 55 · see citing works

Cellular longevity: role of apoptosis and replicative senescence

Bree, R. T., Stenson-Cox, C., Grealy, M., Byrnes, L., Gorman, A. M., & Afshin Samali, A. (2002) · Biogerontology · doi:10.1023/a:1016299812327 · Cited by 53 · see citing works

Cultured cerebellar granule neurons as an in vitro aging model: Topoisomerase IIβ as an additional biomarker in DNA repair and aging

Bhanu, M. U., Mandraju, R. K., Bhaskar, C., & Kondapi, A. K. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.08.003 · Cited by 50 · see citing works

Reduced expression ofMECP2affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome

Squillaro, T., Alessio, N., Cipollaro, M., Melone, M. A. B., Hayek, G., Renieri, A., Giordano, A., & Galderisi, U. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0784 · Cited by 50 · see citing works

Age‐induced hypertrophy of astrocytes in rat supraoptic nucleus: A cytological, morphometric, and immunocytochemical study

Berciano, M. T., Andrés, M. A., Calle, E., & Lafarga, M. (1995) · The Anatomical Record · doi:10.1002/ar.1092430115 · Cited by 50 · see citing works

MeCP2 Phosphorylation Limits Psychostimulant-Induced Behavioral and Neuronal Plasticity

Deng, J. V., Wan, Y., Wang, X., Cohen, S., Wetsel, W. C., Greenberg, M. E., Kenny, P. J., Calakos, N., & West, A. E. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2821-13.2014 · Cited by 49 · see citing works

Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment

Kim, H., Bing, G., Jhoo, W., Kim, W.-K., Shin, E., Park, E.-S., Choi, Y.-S., Lee, D., Shin, C. Y., Ryu, J. R., et al. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00382-5 · Cited by 49 · see citing works

Quantitative morphological changes in neurons and glia in the frontal lobe of the aging rat

Peinado, M. Á., Martínez, M., Pedrosa, J. Á., Quesada, A., & Peinado, J. M. (1993) · The Anatomical Record · doi:10.1002/ar.1092370110 · Cited by 48 · see citing works

Lysosomal β-Galactosidase and β-Hexosaminidase Activities Correlate with Clinical Stages of Dementia Associated with Alzheimer's Disease and Type 2 Diabetes Mellitus

Tiribuzi, R., Orlacchio, A., Crispoltoni, L., Maiotti, M., Zampolini, M., De Angeliz, M., Mecocci, P., Cecchetti, R., Bernardi, G., Datti, A., et al. (2011) · Journal of Alzheimer’s Disease · doi:10.3233/jad-2011-100525 · Cited by 43 · see citing works

Age-related accumulation of lipofuscin in three different regions of rat brain

Oenzil, F., Kishikawa, M., Mizuno, T., & Nakano, M. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)91590-3 · Cited by 38 · see citing works

Remodeling chromatin for senescence.

Adams, P. D. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00313.x · Cited by 37 · see citing works

Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers

Santarosa, M., Col, L. D., Tonin, E., Caragnano, A., Viel, A., & Maestro, R. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0951 · Cited by 33 · see citing works

Senescence-associated lysosomalα-L-fucosidase (SA-α-Fuc): A sensitive and more robust biomarker for cellular senescence beyond SA-β-Gal

Singh, M., & Piekorz, R. P. (2013) · Cell Cycle · doi:10.4161/cc.25318 · Cited by 31 · see citing works

Microinjection of anti-p21 antibodies induces senescent Hs68 human fibroblasts to synthesize DNA but not to divide.

Ma, Y., Prigent, S. A., Born, T. L., Monell, C. R., Feramisco, J. R., & Bertolaet, B. L. (1999) · PubMed · Cited by 24 · see citing works

The effect of sulfated hyaluronan on the morphological transformation and activity of cultured human astrocytes

Yamada, T., Sawada, R., & Tsuchiya, T. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.03.044 · Cited by 23 · see citing works

A study of mitochondria in spinal ganglion neurons during life: Quantitative changes from youth to extremely advanced age

Martinelli, C., Sartori, P., Ledda, M., & Pannese, E. (2006) · Tissue and Cell · doi:10.1016/j.tice.2005.12.002 · Cited by 21 · see citing works

Increased Age Is Associated With Epigenetic and Structural Changes in Chromatin From Neuronal Nuclei

Rodrigues, H. F., de Souza, T. A., Ghiraldini, F. G., Mello, M. L. S., & Moraes, A. D. S. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24705 · Cited by 17 · see citing works

Decrease in the nucleo-cytoplasmic volume ratio of rabbit spinal ganglion neurons with age

Ledda, M., Barni, L., Altieri, L., & Pannese, E. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01116-2 · Cited by 14 · see citing works

A Micro-RNA Connection in BRafV600E -Mediated Premature Senescence of Human Melanocytes

Ren, G., Feng, J., Datar, I. J., Yeung, A. H., Saladi, S. V., Feng, Y., de la Serna, I. L., & Yeung, K. C. (2012) · International Journal of Cell Biology · doi:10.1155/2012/913242 · Cited by 8 · see citing works

Untitled work

(1998) · doi:10.1002/(sici)1097-4547(19980615)52:6

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Singh, A., Kukreti, R., Saso, L., & Kukreti, S. (2019) · Molecules · doi:10.3390/molecules24081583 · Cited by 2,305 · see citing works

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Bussian, T. J., Aziz, A., Meyer, C. F., Swenson, B. L., van Deursen, J. M., & Baker, D. J. (2018) · Nature · doi:10.1038/s41586-018-0543-y · Cited by 1,289 · see citing works

Inflammasome signalling in brain function and neurodegenerative disease

Heneka, M. T., McManus, R. M., & Latz, E. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0055-7 · Cited by 836 · see citing works

Role of p53 in the Regulation of Cellular Senescence

Mijit, M., Caracciolo, V., Melillo, A., Amicarelli, F., & Giordano, A. (2020) · Biomolecules · doi:10.3390/biom10030420 · Cited by 639 · see citing works

Cellular senescence in brain aging

Sikora, E., Bielak-Zmijewska, A., Dudkowska, M., Krzystyniak, A., Mosieniak, G., Wesierska, M., & Wlodarczyk, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646924 · Cited by 304 · see citing works

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

Saez-Atienzar, S., & Masliah, E. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0325-z · Cited by 257 · see citing works

Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

Mangold, C. A., Wronowski, B., Du, M., Masser, D. R., Hadad, N., Bixler, G. V., Brucklacher, R. M., Ford, M. M., Sonntag, W. E., & Freeman, W. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0920-8 · Cited by 203 · see citing works

Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons

Riessland, M., Kolisnyk, B., Kim, T. W., Cheng, J., Ni, J., Pearson, J. A., Park, E. J., Dam, K., Acehan, D., Ramos-Espiritu, L. S., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.013 · Cited by 180 · see citing works

Astrocyte senescence promotes glutamate toxicity in cortical neurons

Limbad, C., Oron, T. R., Alimirah, F., Davalos, A. R., Tracy, T. E., Gan, L., Desprez, P.-Y., & Campisi, J. (2020) · PLOS ONE · doi:10.1371/journal.pone.0227887 · Cited by 183 · see citing works

Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

Pellegrini, C., Antonioli, L., Calderone, V., Colucci, R., Fornai, M., & Blandizzi, C. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101806 · Cited by 174 · see citing works

Oxidative stress, cellular senescence and ageing

Pole, A., Dimri, M., & Dimri, G. P. (2016) · AIMS molecular science · doi:10.3934/molsci.2016.3.300 · Cited by 158 · see citing works

Impact of pulse pressure on cerebrovascular events leading to age-related cognitive decline

Thorin‐Trescases, N., de Montgolfier, O., Pinçon, A., Raignault, A., Caland, L., Labbé, P., & Thorin, É. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00637.2017 · Cited by 151 · see citing works

The costs and benefits of senotherapeutics for human health

Raffaele, M., & Vinciguerra, M. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00300-7 · Cited by 140 · see citing works

From cellular senescence to Alzheimer’s disease: The role of telomere shortening

Boccardi, V., Pelini, L., Ercolani, S., Ruggiero, C., & Mecocci, P. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.003 · Cited by 121 · see citing works

Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases

Balasubramanian, P., Hall, D., & Subramanian, M. (2018) · GeroScience · doi:10.1007/s11357-018-0048-5 · Cited by 110 · see citing works

Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases

Pellegrini, C., Fornai, M., Antonioli, L., Blandizzi, C., & Calderone, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122876 · Cited by 110 · see citing works

At the Crossroads Between Neurodegeneration and Cancer: A Review of Overlapping Biology and Its Implications

Houck, A. L., Seddighi, S., & Driver, J. A. (2018) · Current Aging Science · doi:10.2174/1874609811666180223154436 · Cited by 93 · see citing works

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models

Verma, D., Seo, B. A., Ghosh, A., Ma, S.-X., Hernandez-Quijada, K., Andersen, J. K., Ko, H. S., & Kim, Y. (2021) · Cells · doi:10.3390/cells10071694 · Cited by 85 · see citing works

Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy

Uemura, N., Uemura, M. T., Lo, A., Bassil, F., Zhang, B., Luk, K. C., Lee, V. M. ‐., Takahashi, R., & Trojanowski, J. Q. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz070 · Cited by 81 · see citing works

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

Ohashi, M., Korsakova, E., Allen, D., Lee, P., Fu, K., Vargas, B. S., Cinkornpumin, J., Salas, C., Park, J. C., Germanguz, I., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.04.001 · Cited by 80 · see citing works

Evidence of sex differences in cellular senescence

Ng, M., & Hazrati, L. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.08.014 · Cited by 80 · see citing works

Cell senescence in neuropathology: A focus on neurodegeneration and tumours

Carreno, G., Guiho, R., & Martı́nez-Barberá, J. P. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12689 · Cited by 77 · see citing works

Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?

Abbadie, C., Pluquet, O., & Pourtier, A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2587-9 · Cited by 74 · see citing works

Cellular senescence: a hitchhiker’s guide

Aravinthan, A. D. (2015) · Human Cell · doi:10.1007/s13577-015-0110-x · Cited by 73 · see citing works

Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration

Chae, J., Jang, H., Son, C., Park, C., Choi, H., Jin, S., Lee, H., Lee, H., Ryu, J., Kim, N., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00457-4 · Cited by 63 · see citing works

LARS2 Regulates Apoptosis via ROS‐Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells

Feng, S., Wan, S., Liu, S., Wang, W., Tang, M., Bai, L., & Zhu, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5501346 · Cited by 61 · see citing works

The killifish visual system as an in vivo model to study brain aging and rejuvenation

Vanhunsel, S., Bergmans, S., Beckers, A., Etienne, I., Van houcke, J., Seuntjens, E., Arckens, L., De Groef, L., & Moons, L. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00077-4 · Cited by 58 · see citing works

Potential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection

Mbara, K. C., Devnarain, N., & Owira, P. M. O. (2022) · Pharmaceutical Medicine · doi:10.1007/s40290-022-00444-w · Cited by 60 · see citing works

Redox Biology in Neurological Function, Dysfunction, and Aging

Franco, R., & Vargas, M. R. (2018) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2018.7509 · Cited by 68 · see citing works

Targeting normal and cancer senescent cells as a strategy of senotherapy

Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100941 · Cited by 57 · see citing works

Intermittent Short Sleep Results in Lasting Sleep Wake Disturbances and Degeneration of Locus Coeruleus and Orexinergic Neurons

Zhu, Y., Fenik, P., Zhan, G., Somach, R. T., Xin, R., & Veasey, S. C. (2016) · SLEEP · doi:10.5665/sleep.6030 · Cited by 56 · see citing works

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

Andriani, G. A., Vijg, J., & Montagna, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.007 · Cited by 55 · see citing works

Senotherapeutics: Targeting senescent cells for the main age-related diseases

Boccardi, V., & Mecocci, P. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111526 · Cited by 52 · see citing works

The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling

Osorio, C. P., Kanukuntla, T., Diaz, E. L., Jafri, N., Cummings, M., & Sfera, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00143 · Cited by 49 · see citing works

Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer’s type

Martino Adami, P. V., Orellana, A., García, P., Kleineidam, L., Alarcón-Martín, E., Montrreal, L., Aguilera, N., Espinosa, A., Abdelnour, C., Rosende-Roca, M., et al. (2022) · Brain · doi:10.1093/brain/awac024 · Cited by 46 · see citing works

Aging, Senescence, and Dementia

Behfar, Q., Zuniga, A. R., & Adami, P. V. M. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.42 · Cited by 49 · see citing works

The role of cellular senescence in aging through the prism of Koch-like criteria

Yanai, H., & Fraifeld, V. E. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2017.10.004 · Cited by 45 · see citing works

Cellular Senescence, Neurological Function, and Redox State

Maciel-Barón, L. Á., Moreno-Blas, D., Morales-Rosales, S. L., González‐Puertos, V. Y., López‐Díazguerrero, N. E., Torres, C. A., Castro‐Obregón, S., & Königsberg, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7112 · Cited by 45 · see citing works

Of Energy and Entropy: The Ineluctable Impact of Aging in Old Age Dementia

Boccardi, V., Comanducci, C., Baroni, M., & Mecocci, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122672 · Cited by 45 · see citing works

Cell Cycle and Senescence Regulation by Podocyte Histone Deacetylase 1 and 2

Rangel, P. X. M., Cross, E., Liu, C., Pedigo, C. E., Tian, X., Gutiérrez-Calabrés, E., Nagata, S., Priyadarshini, A., Lerner, G., Bunda, P., et al. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022050598 · Cited by 46 · see citing works

β-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes

Robinson, K. F., Narasipura, S. D., Wallace, J., Ritz, E. M., & Al‐Harthi, L. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00565-2 · Cited by 41 · see citing works

DNA Damage Response-Associated Cell Cycle Re-Entry and Neuronal Senescence in Brain Aging and Alzheimer’s Disease

Wong, G. C., & Chow, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220203 · Cited by 40 · see citing works

A guide to senolytic intervention in neurodegenerative disease

Lee, S., Wang, E. Y., Steinberg, A. B., Walton, C. C., Chinta, S. J., & Andersen, J. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111585 · Cited by 43 · see citing works

The role of cofilin in age-related neuroinflammation

Alsegiani, A. S., & Shah, Z. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.274330 · Cited by 25 · see citing works

Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets

Brokaw, D. L., Piras, I. S., Mastroeni, D., Weisenberger, D. J., Nolz, J., Delvaux, E., Serrano, G. E., Beach, T. G., Huentelman, M. J., & Coleman, P. D. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.06.022 · Cited by 38 · see citing works

Neuroprotective effects of the catalytic subunit of telomerase: A potential therapeutic target in the central nervous system

González‐Giraldo, Y., Forero, D. A., Echeverrı́a, V., González, J., Ávila-Rodriguez, M., García‐Segura, L. M., & Barreto, G. E. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.004 · Cited by 38 · see citing works

Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury

Andrews, R. N., Caudell, D. L., Metheny‐Barlow, L. J., Peiffer, A. M., Tooze, J. A., Bourland, J. D., Hampson, R. E., Deadwyler, S. A., & Cline, J. M. (2018) · Radiation Research · doi:10.1667/rr14961.1 · Cited by 37 · see citing works

Nutrition and cellular senescence in obesity-related disorders

Rubio‐Tomás, T., Rueda‐Robles, A., Plaza‐Díaz, J., & Álvarez‐Mercado, A. I. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108861 · Cited by 37 · see citing works

The Molecular Intersection Between Senescence and Major Depression in the Elderly

Diniz, B. S. (2018) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2018.07.005 · Cited by 35 · see citing works

Blood–brain barrier dysfunction promotes astrocyte senescence through albumin‐induced TGFβ signaling activation

Preininger, M. K., Zaytseva, D., Lin, J. M., & Kaufer, D. (2023) · Aging Cell · doi:10.1111/acel.13747 · Cited by 36 · see citing works

High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression

Xue, W.-J., He, C.-F., Zhou, R., Xu, X.-D., Xiang, L.-X., Wang, J., Wang, X., Zhou, H., & Guo, J.-C. (2022) · Molecular Brain · doi:10.1186/s13041-022-00947-2 · Cited by 34 · see citing works

Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights

Kulkarni, N. P., Vaidya, B., Narula, A. S., & Sharma, S. S. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210608165509 · Cited by 31 · see citing works

Brain Aging and Late-Onset Alzheimer’s Disease: A Matter of Increased Amyloid or Reduced Energy?

Mecocci, P., Baroni, M., Senin, U., & Boccardi, V. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179903 · Cited by 29 · see citing works

SIRT1 safeguards adipogenic differentiation by orchestrating anti-oxidative responses and suppressing cellular senescence

An, Y., Yu, R., Liu, H., Ge, C., & Dang, W. (2023) · GeroScience · doi:10.1007/s11357-023-00863-w · Cited by 28 · see citing works

Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells

Kim, S.-B., Heo, J.-I., Kim, H., & Kim, K. S. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly167 · Cited by 28 · see citing works

Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function

Palmer, A., Epton, S., Crawley, E., Straface, M., Gammon, L., Edgar, M. M., Xu, Y., Elahi, S., Chin‐Aleong, J., Martin, J. E., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.747067 · Cited by 27 · see citing works

Aging: A cell source limiting factor in tissue engineering

Khorraminejad‐Shirazi, M., Dorvash, M., Estedlal, A., Hoveidaei, A. H., Mazloomrezaei, M., & Mosaddeghi, P. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i10.787 · Cited by 27 · see citing works

Progerin-Induced Transcriptional Changes in Huntington’s Disease Human Pluripotent Stem Cell-Derived Neurons

Cohen-Carmon, D., Sorek, M., Lerner, V., Sivaraman, D. M., Nissim‐Rafinia, M., Yarom, Y., & Meshorer, E. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01839-8 · Cited by 23 · see citing works

Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein

Krejciova, Z., Carlson, G. A., Giles, K., & Prusiner, S. B. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0703-9 · Cited by 19 · see citing works

Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids

Möller, S., Saul, N., Cohen, A. A., Köhling, R., Sender, S., Escobar, H. M., Junghanß, C., Cirulli, F., Berry, A., Antal, P., et al. (2020) · Aging · doi:10.18632/aging.103514 · Cited by 17 · see citing works

Alzheimer's Disease and Aging Association: Identification and Validation of Related Genes

Liu, T., Hou, K., Li, J., Han, T., Liu, S., & Wei, J. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.101 · Cited by 17 · see citing works

NS1 of H7N9 Influenza A Virus Induces NO-Mediated Cellular Senescence in Neuro2a Cells

Yan, Y., Du, Y., Zheng, H., Wang, G., Li, R., Chen, J., & Li, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000481848 · Cited by 17 · see citing works

A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype

Porterfield, V. M., Khan, S. S., Foff, E. P., Köseoğlu, M. M., Blanco, I. K., Jayaraman, S., Lien, E. L., McConnell, M. J., Bloom, G. S., Lazo, J. S., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.011 · Cited by 17 · see citing works

Redox lipidomics and adductomics - Advanced analytical strategies to study oxidized lipids and lipid-protein adducts

Cruciani, G., Domingues, P. M., Fedorova, M., Galli, F., & Spickett, C. M. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.07.027 · Cited by 16 · see citing works

Effect of Cellular Senescence in Disease Progression and Transplantation: Immune Cells and Solid Organs

Kirchner, V. A., Badshah, J. S., Hong, S. K., Martinez, O. M., Pruett, T. L., & Niedernhofer, L. J. (2023) · Transplantation · doi:10.1097/tp.0000000000004838 · Cited by 15 · see citing works

Designing neuroreparative strategies using aged regenerating animal models

Vanhunsel, S., Beckers, A. M., & Moons, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101086 · Cited by 14 · see citing works

Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage

Malojirao, V. H., Vasquez, V., Kodavati, M., Mitra, J., Provasek, V., Voh, A. T. T., Liopo, A. V., Derry, P. J., Mikheev, A. M., Rostomily, R. C., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07983-3 · Cited by 13 · see citing works

Role of Telomeres and Telomerase in Parkinson's Disease—A New Theranostics?

Vellingiri, B., Balasubramani, K., Iyer, M., Raj, N., Elangovan, A., Song, K., Yeo, H. C., Jayakumar, N., Kinoshita, M., Ravimanickam, T., et al. (2023) · Advanced Biology · doi:10.1002/adbi.202300097 · Cited by 14 · see citing works

Spatio-temporal correlates of gene expression and cortical morphology across lifespan and aging

Qiu, A., Zhang, H., Kennedy, B. K., & Lee, A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117426 · Cited by 10 · see citing works

Role of Senescence and Neuroprotective Effects of Telomerase in Neurodegenerative Diseases

Ding, X., Liu, X., Wang, F., Wang, F., & Geng, X. (2019) · Rejuvenation Research · doi:10.1089/rej.2018.2115 · Cited by 11 · see citing works

Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2

Zhawar, V. K., Kandpal, R. P., & Athwal, R. S. (2020) · Cancer Genomics & Proteomics · doi:10.21873/cgp.20225 · Cited by 10 · see citing works

Polyphenols and Diets as Current and Potential Nutrition Senotherapeutics in Alzheimer’s Disease: Findings from Clinical Trials

Chen, X., Walton, K. L., Brodaty, H., & Chalton, K. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231222 · Cited by 10 · see citing works

ShcC proteins: Brain aging and beyond

Sagi, O., Budovsky, A., Wolfson, M., & Fraifeld, V. E. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.002 · Cited by 10 · see citing works

Evaluating the Remote Control of Programmed Cell Death, with or without a Compensatory Cell Proliferation

Dou, X., Chen, L., Lei, M., Zellmer, L., Jia, Q., Ling, P., He, Y., Yang, W., & Liao, D. J. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.26962 · Cited by 10 · see citing works

Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson's Disease

Scott, K. M., & Williams‐Gray, C. H. (2018) · Movement Disorders · doi:10.1002/mds.27387 · Cited by 10 · see citing works

Nanomedicines targeting the inflammasome as a promising therapeutic approach for cell senescence

Chaturvedi, S., Naseem, Z., El‐Khamisy, S. F., & Wahajuddin, M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.08.008 · Cited by 9 · see citing works

Dopaminergic mediation in the brain aging and neurodegenerative diseases: a role of senescent cells

Nekrasov, P. V., & Vorobyov, V. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.230290 · Cited by 9 · see citing works

Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration

Sharma, K., Sarkar, J., Trisal, A., Ghosh, R., Dixit, A., & Singh, A. K. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.02.016 · Cited by 8 · see citing works

Senolytics as Modulators of Critical Signaling Pathways: a Promising Strategy to Combat Brain Aging and Neurodegenerative Disorders

Singh, I., & Singh, A. K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05504-1 · Cited by 8 · see citing works

Reelin Alleviates Mesenchymal Stem Cell Senescence and Reduces Pathological α-Synuclein Expression in an In Vitro Model of Parkinson’s Disease

Cho, E., Park, J., Kim, K., Kim, M., & Cho, S. (2021) · Genes · doi:10.3390/genes12071066 · Cited by 8 · see citing works

Animal Models of Alzheimer’s Disease

Amram, S., & Frenkel, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00003-x · Cited by 8 · see citing works

Age-related changes in the primary auditory cortex of newborn, adults and aging bottlenose dolphins (Tursiops truncatus) are located in the upper cortical layers

Graïc, J., Corain, L., Finos, L., Vadori, V., Grisan, E., Gerussi, T., Orekhova, K., Centelleghe, C., Cozzi, B., & Peruffo, A. (2024) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2023.1330384 · Cited by 7 · see citing works

Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology

Dou, X., Tong, P., Huang, H., Zellmer, L., He, Y., Jia, Q., Zhang, D., Peng, J., Wang, C., Xu, N., et al. (2020) · Journal of Cancer · doi:10.7150/jca.41324 · Cited by 7 · see citing works

New Insight in The Molecular Mechanisms of Neurodegenerative Disease

Meiliana, A., Dewi, N. M., & Wijaya, A. (2018) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v10i1.448 · Cited by 6 · see citing works

Spontaneous Cancers, But Not Many Induced Ones in Animals, Resemble Semi-New Organisms that Possess a Unique Programmed Cell Death Mode Different from Apoptosis, Senescent Death, Necrosis and Stress-Induced Cell Death

Shi, M., Zhou, H., Lei, M., Chen, L., Zellmer, L., He, Y., Yang, W., Xu, N., & Liao, D. J. (2018) · Journal of Cancer · doi:10.7150/jca.26502 · Cited by 6 · see citing works

Astrocyte senescence in an Alzheimer’s disease mouse model is mediated by TGF-β1 and results in neurotoxicityPreprint

Amram, S., Iram, T., Lazdon, E., Vassar, R. J., Ben‐Porath, I., & Frenkel, D. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/700013 · Cited by 5 · see citing works

The preventive use of resveratrol increases its antioxidant effect by SIRT1 and subclinical anti-inflammatory action in Neuro-2A cells

Lara, R. C., Franco, F. N., de Araújo, G. R., Silva, B. N. M., & Chaves, M. M. (2022) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-022-00719-1 · Cited by 4 · see citing works

[The effect of deep branches of cervical nerve on motorial function of trapezius muscle].

Wang, F., Wen, Y., & Li, L. (2003) · PubMed · Cited by 4 · see citing works

Age-related diseases: common or diverse pathways?

Demetrius, L., & Fraifeld, V. E. (2014) · Biogerontology · doi:10.1007/s10522-014-9543-y · Cited by 4 · see citing works

Aging, Cellular Senescence, and Glaucoma

Zhang, Y., Huang, S., Xie, B., & Zhong, Y. (2023) · Aging and Disease · doi:10.14336/ad.2023.0631 · Cited by 79 · see citing works

Chromatin Structure from Development to Ageing

Ayala-Guerrero, L., Claudio-Galeana, S., Furlan-Magaril, M., & Castro‐Obregón, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_2 · Cited by 2 · see citing works

Correspondence regarding two recent publications in npj:schizophrenia about DNAm and accelerated aging in schizophrenia

Fernández-Egea, E., & Kirkpatrick, B. W. (2017) · Schizophrenia · doi:10.1038/s41537-017-0041-5 · Cited by 3 · see citing works

Anti-ageing and attenuating cognitive declines of Dicliptera chinensis extracts and purified compounds in vitro and in scopolamine-induced cognitive dysfunction mice

Sie, Y.-Y., Lee, M., & Hou, W. (2025) · Botanical studies · doi:10.1186/s40529-025-00478-8 · Cited by 2 · see citing works

Cellular Senescence in the Aging Brain

Mishra, R. (2025) · Springer eBooks · doi:10.1007/978-981-96-8873-9_4 · Cited by 2 · see citing works

Molecular and Cellular Evidence for Age by Disease Interactions: Updates and Path Forward

Shukla, R., Oh, H., & Sibille, E. L. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.06.001 · Cited by 2 · see citing works

Aging and Cardiovascular Diseases: The Role of Cellular Senescence

Bozaykut, P. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_10 · Cited by 3 · see citing works

Loss of MECP2 leads to activation of p53 and neuronal senescencePreprint

Ohashi, M., Allen, D., Lee, P., Korsakova, E., Fu, K., Vargas, B., Cinkornpumin, J., Salas, C., Park, J., Germanguz, I., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/130401 · Cited by 2 · see citing works

Exploring the uncharted role of cell senescence in rare diseases

Selvaggio, P., Taci, E., Barassi, A., Massa, V., Gervasini, C., Lesma, E. A., Bernardelli, C., & Fede, E. D. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-03778-1 · Cited by 1 · see citing works

Effects of senescence on astrocyte to brain endothelial cell signaling

Guo, S., Hamanaka, G., Zhang, F., Lee, J. C. L., Park, J.-H., Li, W., Arai, K., & Lo, E. H. (2025) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70013 · Cited by 1 · see citing works

Accelerated aging in schizophrenia: integrating epigenetic clocks, telomere dynamics, senescence-associated secretory phenotype, and oxidative stress

Ge, X., Jiang, C., Wu, C., Fang, X., & Zhang, X. (2026) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-026-02325-8 · Cited by 1 · see citing works

Cellular senescence in neurodegenerative diseases

Zhang, P., & Sung, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822514-1.00012-2 · Cited by 10 · see citing works

Cellular senescence in brain aging and neurodegeneration

dos Santos, L. M., Trombetta-Lima, M., Eggen, B. J. L., & Demaria, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102141 · Cited by 158 · see citing works

Cellular senescence in brain aging and neurodegeneration: from molecular mechanisms to translational opportunities

Cantero‐Fortiz, Y., Butler, C., Montalbán, X., & Boada, M. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1805691 · Cited by 5 · see citing works

Cellular Senescence in the Aging Brain

Mishra, R. (2025) · Springer eBooks · doi:10.1007/978-981-96-8873-9_4 · Cited by 2 · see citing works

CELLULAR SENESCENCE: A NOVEL CONTRIBUTOR TO BRAIN AGING AND NEURODEGENERATIVE DISEASE

Andersen, J. K. (2018) · Innovation in Aging · doi:10.1093/geroni/igy023.810 · Cited by 1 · see citing works