Chemical composition, aroma evaluation, and inhibitory activity towards acetylcholinesterase of essential oils from Gynura bicolor DC
Abstract
The compositions of the essential oils obtained from leaves and stems of Gynura bicolor DC. were analyzed by GC-MS. One hundred eight components of these oils were identified. (E)-β-caryophyllene (31.42 %), α-pinene (17.11 %), and bicyclogermacrene (8.09 %) were found to be the main components of the leaf oil, while α-pinene (61.42 %), β-pinene (14.39 %), and myrcene (5.10 %) were the major constituents of the stem oil. We found 73 previously unidentified components in these oils from G. bicolor. The oils were also subjected to odor evaluation. Eleven and 12 aroma-active compounds were detected in the leaf and stem oils, respectively. The abilities of these oils to inhibit acetylcholinesterase (AChE) activity were determined. The sesquiterpenoids in the oils were found to inhibit AChE activity more strongly than the monoterpenoids in the oils did. It was suggested that the three main components in each essential oil act synergistically against AChE activity. These results show that the essential oils obtained from G. bicolor are a good dietary source of AChE activity inhibition.
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Sesquiterpenoids in essential oil from Gynura bicolor act synergistically against AChE inhibition.
“The sesquiterpenoids in essential oil from the Gynura bicolor were found to act synergistically against AChE inhibition.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [91]
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Arya, A., Chahal, R., Rao, R., Rahman, M. H., Kaushik, D., Akhtar, M. F., Saleem, A., Khalifa, S. M. A., El-Seedi, H. R., Kamel, M., et al. (2021) · Biomolecules · doi:10.3390/biom11030350 · Cited by 111 · see citing works
“[91] investigated the leaf and stem oil of Gynura bicolor DC for AChE inhibitory potential.”
BackgroundToledo, P. F. S., Viteri Jumbo, L. O., Rezende, S. M., Haddi, K., Silva, B. A., Mello, T. S., Della Lucia, T. M. C., Aguiar, R. W. S., Smagghe, G., & Oliveira, E. E. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137328 · Cited by 52 · see citing works
- Authors
- Miyazawa, M., Nakahashi, H., Usami, A., & Matsuda, N.
- Affiliations
- Kindai University (JP)
- Corresponding author
- Miyazawa, Mitsuo
- Venue
- Journal of Natural Medicines
- Published
- 2016-01-12
- Volume
- 70
- Issue
- 2
- Pages
- 282-289
- ISSN
- 1340-3443 (ISSN-L)
- 1861-0293
- OpenAlex
- W2236195079
- Cited by
- 34
- References
- 13
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Natural Medicines (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- Gynura bicolor, essential oils, chemical composition, aroma-active compounds, acetylcholinesterase inhibition, sesquiterpenes, monoterpenoids, (E)-caryophyllene, α-pinene, bicyclogermacrene, synergistic inhibition, Alzheimer's disease
- MeSH terms
- Acyclic Monoterpenes, Bicyclic Monoterpenes, Polycyclic Sesquiterpenes, Acetylcholinesterase, Alkenes, Bridged Bicyclo Compounds, Cholinesterase Inhibitors, Humans, Gas Chromatography-Mass Spectrometry, Odorants, Oils, Volatile, Plant Extracts, Sesquiterpenes, Plant Leaves, Plant Stems, Asteraceae, Monoterpenes
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