Whitening and anti-wrinkle activities of ferulic acid isolated from Tetragonia tetragonioides in B16F10 melanoma and CCD-986sk fibroblast cells
Abstract
Ferulic acid isolated from Tetragonia tetragonioides was tested for its whitening effect on the B16F10 mouse melanoma cell line and its anti-wrinkle activity on the CCD-986sk human dermal fibroblast cell line. Ferulic acid, one of the primary phenolic compounds that can be isolated from T. tetragonioides, has been reported to show potential as a functional food, for its whitening effect and anti-wrinkle activity. To measure its whitening and anti-wrinkle activities, cells were treated with ferulic acid isolated from T. tetragonioides at concentrations between 5 and 20 μM. Ferulic acid showed no cytotoxicity at concentrations up to 20 μM. Ferulic acid inhibited melanin synthesis, tyrosinase expression, and microphthalmia transcription factor expression in B16F10 cells stimulated with α-melanocyte stimulating hormone. Ferulic acid induced procollagen synthesis, hyaluronic acid synthesis, tissue inhibitor of metalloproteinase synthesis, and inhibited matrix metalloproteinase (MMP)-1 and MMP-9 expression in CCD-986sk cells stimulated with UV-B. On the basis of these results, we conclude that ferulic acid isolated from T. tetragonioides shows potential for use as a functional food, with whitening and anti-wrinkle activities.
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Ferulic acid inhibits matrix metalloproteinases and promotes the production of tissue inhibitors of metalloproteinases.
“In addition to its antioxidant properties, ferulic acid inhibits matrix metalloproteinases and promotes the production of tissue inhibitors of metalloproteinases, which likely contributed to the increased skin elasticity observed in this study.26,27”
Ferulic acid's inhibition of matrix metalloproteinases and promotion of tissue inhibitors of metalloproteinases likely contributed to the increased skin elasticity observed in this study.
“In addition to its antioxidant properties, ferulic acid inhibits matrix metalloproteinases and promotes the production of tissue inhibitors of metalloproteinases, which likely contributed to the increased skin elasticity observed in this study.26,27”
Cites
Baumann, L. (2007) · The Journal of Pathology · doi:10.1002/path.2098 · Cited by 675 · see citing works
Pluemsamran, T., Onkoksoong, T., & Panich, U. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01118.x · Cited by 140 · see citing works
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Versatile Applications of Cyanobacteria in Biotechnology
Żymańczyk-Duda, E., Samson, S. O., Brzezińska-Rodak, M., & Klimek-Ochab, M. (2022) · Microorganisms · doi:10.3390/microorganisms10122318 · Cited by 64 · see citing works
Kang, Y.-M., Hong, C.-H., Kang, S.-H., Seo, D.-S., Kim, S.-O., Lee, H.-Y., Sim, H.-J., & An, H.-J. (2020) · Journal of Functional Biomaterials · doi:10.3390/jfb11010003 · Cited by 45 · see citing works
Kamila, M. Z., & Helena, R. (2020) · Dermatologic Therapy · doi:10.1111/dth.14000 · Cited by 27 · see citing works
Wawrzyńczak, A. (2023) · Cosmetics · doi:10.3390/cosmetics10030086 · Cited by 19 · see citing works
Liu, C., Boo, J., Kim, H., Hwang, S., Yan, X., Brieva, P., Kim, J., & Kim, J. (2026) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s565035 · Cited by 1 · see citing works
“26,27 The enhanced penetration provided by microneedling, coupled with the combination of these three antioxidant ingredients, explains the synergistic effects of antioxidant serum (15% vitamin C, 1% vitamin E, and 0.5% ferulic acid) observed in this study at a time point as early as four weeks.”
Influential
- Authors
- Park, H.-J., Cho, J.-H., Hong, S.-H., Kim, D.-H., Jung, H.-Y., Kang, I.-K., & Cho, Y.-J.
- Affiliations
- Kyungpook National University (KR)
- National Development Institute of Korean Medicine (KR)
- Corresponding author
- Cho, Young-Je
- Venue
- Journal of Natural Medicines
- Published
- 2017-09-07
- Volume
- 72
- Issue
- 1
- Pages
- 127-135
- ISSN
- 1340-3443 (ISSN-L)
- 1861-0293
- OpenAlex
- W2750661454
- Cited by
- 85
- References
- 2
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 8 · 2023: 10 · 2022: 15 · 2021: 11 · 2020: 13 · 2019: 6 · 2018: 1
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Natural Medicines (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- ferulic acid, Tetragonia tetragonoides, skin lightening, anti-wrinkle activity, melanogenesis inhibition, tyrosinase, microphthalmia-associated transcription factor, alpha-melanocyte-stimulating hormone, B16F10 melanoma cells, dermal fibroblasts, procollagen synthesis, hyaluronic acid, MMP-1, MMP-9, tissue inhibitors of metalloproteinases, functional foods
- MeSH terms
- Animals, Coumaric Acids, Fibroblasts, Humans, Melanins, Melanoma, Skin Aging, Cell Line, Tumor, Mice
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