Cited by 140Skin Protection and AgingPhytochemicals and Antioxidant Activitiesmelanin and skin pigmentation

Caffeic Acid and Ferulic Acid Inhibit UVA‐Induced Matrix Metalloproteinase‐1 through Regulation of Antioxidant Defense System in Keratinocyte HaCaT Cells

Pluemsamran, Thanyawan, Onkoksoong, Tasanee, Panich, Uraiwan·2012·Photochemistry and Photobiology

Abstract

Ultraviolet A (UVA) plays a vital role in the pathogenesis of premature skin aging through keratinocyte cytotoxicity and degradation of collagen, a main component of the extracellular matrix providing structural support. Oxidative stress caused by UVA irradiation can mediate induction of matrix metalloprotease‐1 (MMP‐1), a major enzyme responsible for collagen damage. Protection against UV‐mediated disturbance of antioxidant defense system has been proposed as a possible mechanism by which botanical compounds slow down skin aging process. This study therefore aimed to assess inhibitory effects of caffeic acid (CA) and ferulic acid (FA), powerful plant‐based phenolic antioxidants, on UVA‐induced cytotoxicity and MMP‐1 activity and mRNA level through modulation of antioxidant defense mechanism in immortalized human keratinocyte (HaCaT) cells. Pretreatment of the cells with CA or FA prior to UVA irradiation inhibited cytotoxicity, induction of MMP‐1 activity and mRNA and oxidant formation. Moreover, CA and FA were able to up‐regulate glutathione (GSH) content, γ‐glutamate cysteine ligase (γ‐GCL) mRNA as well as activities and mRNA expression of catalase and glutathione peroxidase (GPx) in irradiated cells. In conclusion, CA and FA provided protective effects on UVA‐mediated MMP‐1 induction in HaCaT cells possibly through restoration of antioxidant defense system at the cellular and molecular level.

Integrity signals

Registry

Crossref · 10.1111/j.1751-1097.2012.01118.x

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 31 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Pluemsamran, T., Onkoksoong, T., & Panich, U.
Affiliations
Siriraj Hospital (TH)
Corresponding author
Panich, Uraiwan
Venue
Photochemistry and Photobiology
Publisher
Wiley
Published
2012-04-20
Volume
88
Issue
4
Pages
961-968
ISSN
  • 0031-8655 (ISSN-L)
  • 1751-1097
OpenAlex
W2045951593
Cited by
140
References
31
Citations by year
2026: 6 · 2025: 14 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 22 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 1
FWCI
8.82
Type
journal article
Language
en
Open access
closed
Locations
  • Photochemistry and Photobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
caffeic acid, ferulic acid, UVA, MMP-1, keratinocytes, HaCaT keratinocytes, skin aging, oxidative stress, antioxidant defense, glutathione, gamma-glutamylcysteine synthetase, catalase, glutathione peroxidase, collagen degradation, phenolic antioxidants
MeSH terms
Antioxidants, Caffeic Acids, Catalase, Cell Line, Transformed, Coumaric Acids, Glutamate-Cysteine Ligase, Gene Expression Regulation, Glutathione, Glutathione Peroxidase, Humans, RNA, Messenger, Ultraviolet Rays, Skin Aging, Keratinocytes, Oxidative Stress, Matrix Metalloproteinase 1, Matrix Metalloproteinase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review