Caffeic Acid and Ferulic Acid Inhibit UVA‐Induced Matrix Metalloproteinase‐1 through Regulation of Antioxidant Defense System in Keratinocyte HaCaT Cells
Abstract
Ultraviolet A (UVA) plays a vital role in the pathogenesis of premature skin aging through keratinocyte cytotoxicity and degradation of collagen, a main component of the extracellular matrix providing structural support. Oxidative stress caused by UVA irradiation can mediate induction of matrix metalloprotease‐1 (MMP‐1), a major enzyme responsible for collagen damage. Protection against UV‐mediated disturbance of antioxidant defense system has been proposed as a possible mechanism by which botanical compounds slow down skin aging process. This study therefore aimed to assess inhibitory effects of caffeic acid (CA) and ferulic acid (FA), powerful plant‐based phenolic antioxidants, on UVA‐induced cytotoxicity and MMP‐1 activity and mRNA level through modulation of antioxidant defense mechanism in immortalized human keratinocyte (HaCaT) cells. Pretreatment of the cells with CA or FA prior to UVA irradiation inhibited cytotoxicity, induction of MMP‐1 activity and mRNA and oxidant formation. Moreover, CA and FA were able to up‐regulate glutathione (GSH) content, γ‐glutamate cysteine ligase (γ‐GCL) mRNA as well as activities and mRNA expression of catalase and glutathione peroxidase (GPx) in irradiated cells. In conclusion, CA and FA provided protective effects on UVA‐mediated MMP‐1 induction in HaCaT cells possibly through restoration of antioxidant defense system at the cellular and molecular level.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ferulic acid's inhibition of matrix metalloproteinases and promotion of tissue inhibitors of metalloproteinases likely contributed to the increased skin elasticity observed in this study.
“In addition to its antioxidant properties, ferulic acid inhibits matrix metalloproteinases and promotes the production of tissue inhibitors of metalloproteinases, which likely contributed to the increased skin elasticity observed in this study.26,27”
Ferulic acid inhibits matrix metalloproteinases and promotes the production of tissue inhibitors of metalloproteinases.
“In addition to its antioxidant properties, ferulic acid inhibits matrix metalloproteinases and promotes the production of tissue inhibitors of metalloproteinases, which likely contributed to the increased skin elasticity observed in this study.26,27”
Cites
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501 · see citing works
Photoageing: mechanism, prevention and therapy
Yaar, M., & Gilchrest, B. A. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08108.x · Cited by 755 · see citing works
Brennan, M. M., Bhatti, H., Nerusu, K. C., Bhagavathula, N., Kang, S., Fisher, G. J., Varani, J., & Voorhees, J. J. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0780043mmitmc2.0.co2 · Cited by 358 · see citing works
Rhie, G.-E., Shin, M. H., Seo, J. Y., Choi, W. W., Cho, K. H., Kim, K. H., Park, K. C., Eun, H. C., & Chung, J. H. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01469.x · Cited by 274 · see citing works
Gao, X., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403886101 · Cited by 215 · see citing works
Murray, J. C., Burch, J. A., Streilein, R. D., Iannacchione, M. A., Hall, R. P., & Pinnell, S. R. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.05.004 · Cited by 212 · see citing works
Mantena, S. K., & Katiyar, S. K. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.12.032 · Cited by 203 · see citing works
Brenneisen, P., Briviba, K., Wlaschek, M., Wenk, J., & Scharffetter‐Kochanek, K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00404-2 · Cited by 199 · see citing works
α‐MSH activates immediate defense responses to UV‐induced oxidative stress in human melanocytes
Song, X., Mosby, N., Yang, J., Xu, A., Abdel‐Malek, Z., & Kadekaro, A. L. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00615.x · Cited by 163 · see citing works
Chiang, H., Lin, T.-J., Chiu, C., Chang, C.-W., Hsu, K.-C., Fan, P.-C., & Wen, K. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.10.034 · Cited by 136 · see citing works
Effects of solar radiation on cutaneous detoxification pathways
Afaq, F., & Mukhtar, H. (2001) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(01)00217-2 · Cited by 127 · see citing works
Panich, U., Tangsupa-a-nan, V., Onkoksoong, T., Kongtaphan, K., Kasetsinsombat, K., Akarasereenont, P., & Wongkajornsilp, A. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-0515-3 · Cited by 127 · see citing works
Self-citationHo, J. N., Lee, Y. H., Park, J. S., Jun, W. J., Kim, H. K., Hong, B.-S., Shin, D. H., & Cho, H. Y. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1244 · Cited by 126 · see citing works
Adaptive Antioxidant Response of Manganese-Superoxide Dismutase Following Repetitive UVA Irradiation
Poswig, A., Wenk, J., Brenneisen, P., Wlaschek, M., Hommel, C., Quel, G., Faisst, K., Dissemond, J., Krieg, T., Scharffetter‐Kochanek, K., et al. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00465.x · Cited by 112 · see citing works
Philips, N. E., Smith, J. C., Keller, T., & González, S. (2003) · Journal of Dermatological Science · doi:10.1016/s0923-1811(03)00042-2 · Cited by 99 · see citing works
Caffeic acid modulates ultraviolet radiation-B induced oxidative damage in human blood lymphocytes
Prasad, N. R., Jeyanthimala, K., & Samivel, R. (2009) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2009.03.007 · Cited by 98 · see citing works
Polte, T., & Tyrrell, R. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.003 · Cited by 94 · see citing works
Antioxidants may contribute in the fight against ageing: an in vitro model
Hu, H.-L., Forsey, R. J., Blades, T. J., Barratt, M. E. J., Parmar, P., & Powell, J. R. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00212-8 · Cited by 92 · see citing works
A Reevaluation of the Peroxynitrite Scavenging Activity of Some Dietary Phenolics
Ketsawatsakul, U., Whiteman, M., & Halliwell, B. B. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4014 · Cited by 80 · see citing works
Panich, U., Kongtaphan, K., Onkoksoong, T., Jaemsak, K., Phadungrakwittaya, R., Thaworn, A., Akarasereenont, P., & Wongkajornsilp, A. (2009) · Cell Biology and Toxicology · doi:10.1007/s10565-009-9121-2 · Cited by 65 · see citing works
Self-citationLeccia, M. ‐., Yaar, M., Allen, N., Gleason, M. J., & Gilchrest, B. A. (2001) · Experimental Dermatology · doi:10.1034/j.1600-0625.2001.100407.x · Cited by 61 · see citing works
Tanaka, K., Hasegawa, J., Asamitsu, K., & Okamoto, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.095 · Cited by 58 · see citing works
Horizontal and sun-normal spectral biologically effective ultraviolet irradiances
Parisi, A. V., & Kimlin, M. G. (1999) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(99)00128-1 · Cited by 54 · see citing works
Wertz, K., Seifert, N., Hunziker, P. B., Riss, G., Wyss, A., Lankin, C., & Goralczyk, R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.018 · Cited by 52 · see citing works
Marionnet, C., Grether‐Beck, S., Seité, S., Marini, A., Jaenicke, T., Lejeune, F., Bastien, P., Rougier, A., Bernerd, F., & Krutmann, J. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01265.x · Cited by 48 · see citing works
Yamada, Y., Yasui, H., & Sakurai, H. (2006) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2006.tb09829.x · Cited by 43 · see citing works
Skin cell protection against UVA by Sideroxyl, a new antioxidant complementary to sunscreens
Pygmalion, M.-J., Ruiz, L., Popovic, E., Gizard, J., Portes, P., Marat, X., Lucet-Levannier, K., Muller, B., & Galey, J.-B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.009 · Cited by 37 · see citing works
Zaw, K. K., Yokoyama, Y., M, A., & Ishikawa, O. (2006) · PubMed · doi:10.5281/zenodo.3478842 · Cited by 31 · see citing works
Venditti, E., Brugè, F., Astolfi, P., Kochevar, I. E., & Damiani, E. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.03.008 · Cited by 28 · see citing works
Effects of UVB Radiation on 4-Hydroxy-2-trans-nonenal Metabolism and Toxicity in Human Keratinocytes
Aldini, G., Granata, P., Marinello, C., Beretta, G., Carini, M., & Facino, R. M. (2007) · Chemical Research in Toxicology · doi:10.1021/tx0601657 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 31 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Antioxidant Properties of Ferulic Acid and Its Possible Application
Zduńska‐Pęciak, K., Dana, A., Kołodziejczak, A. M., & Rotsztejn, H. (2018) · Skin Pharmacology and Physiology · doi:10.1159/000491755 · Cited by 872 · see citing works
The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders
Działo, M., Mierziak, J., Korzun, U., Preisner, M., Szopa, J., & Kulma, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020160 · Cited by 686 · see citing works
Taofiq, O., González-Paramás, A., Barreiro, M., & Ferreira, I. (2017) · Molecules · doi:10.3390/molecules22020281 · Cited by 411 · see citing works
Bosch, R., Philips, N., Suárez-Pérez, J., Juarranz, A., Devmurari, A., Chalensouk-Khaosaat, J., & González, S. (2015) · Antioxidants · doi:10.3390/antiox4020248 · Cited by 407 · see citing works
Caffeic acid: a review of its potential use in medications and cosmetics
Magnani, C., Isaac, V. L. B., Corrêa, M. A., & Salgado, H. R. N. (2014) · Analytical Methods · doi:10.1039/c3ay41807c · Cited by 393 · see citing works
Panich, U., Sittithumcharee, G., Rathviboon, N., & Jirawatnotai, S. (2016) · Stem Cells International · doi:10.1155/2016/7370642 · Cited by 374 · see citing works
Self-citationStrawberry and Human Health: Effects beyond Antioxidant Activity
Giampieri, F., Álvarez-Suárez, J. M., & Battino, M. A. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405455n · Cited by 357 · see citing works
Oxidative stress in the skin: Impact and related protection
Chen, J., Liu, Y., Zhao, Z., & Qiu, J. (2021) · International Journal of Cosmetic Science · doi:10.1111/ics.12728 · Cited by 351 · see citing works
Silva, E. D. O., & Batista, R. (2017) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12266 · Cited by 174 · see citing works
Yu, Q., Fan, L., & Duan, Z. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.05.184 · Cited by 167 · see citing works
Kim, S. R., Jung, Y. R., An, H. J., Kim, D. H., Jang, E. J., Choi, Y. J., Moon, K. M., Park, M. H., Park, C. H., Chung, K. W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073877 · Cited by 161 · see citing works
Chaiprasongsuk, A., Onkoksoong, T., Pluemsamran, T., Limsaengurai, S., & Panich, U. (2016) · Redox Biology · doi:10.1016/j.redox.2015.12.006 · Cited by 116 · see citing works
Self-citationPeres, D. D., Sarruf, F. D., de Oliveira, C. A., Velasco, M. V. R., & Baby, A. R. (2018) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2018.05.026 · Cited by 115 · see citing works
Sanjeev, S., Bidanchi, R. M., Murthy, M. K., Gurusubramanian, G., & Roy, V. K. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-05420-7 · Cited by 113 · see citing works
Baldisserotto, A., Buso, P., Radice, M., Dissette, V., Lampronti, I., Gambari, R., Manfredini, S., & Vertuani, S. (2018) · Molecules · doi:10.3390/molecules23030664 · Cited by 111 · see citing works
Chaiprasongsuk, A., Lohakul, J., Soontrapa, K., Sampattavanich, S., Akarasereenont, P., & Panich, U. (2017) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.238048 · Cited by 101 · see citing works
Self-citationStabilization of ferulic acid in topical gel formulation via nanoencapsulation and pH optimization
Das, S., & Wong, A. B. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-68732-6 · Cited by 102 · see citing works
Park, H.-J., Cho, J.-H., Hong, S.-H., Kim, D.-H., Jung, H.-Y., Kang, I.-K., & Cho, Y.-J. (2018) · Journal of Natural Medicines · doi:10.1007/s11418-017-1120-7 · Cited by 85 · see citing works
Synthesis and Antioxidant Activity of Caffeic Acid Derivatives
Sidoryk, K., Jaromin, A., Filipczak, N., Cmoch, P., & Cybulski, M. (2018) · Molecules · doi:10.3390/molecules23092199 · Cited by 85 · see citing works
Preparation, characterization and application of SPI-based blend film with antioxidant activity
Li, T., Xia, N., Xu, L., Zhang, H., Zhang, H., Chi, Y., Zhang, Y., Li, L., & Li, H. (2020) · Food Packaging and Shelf Life · doi:10.1016/j.fpsl.2020.100614 · Cited by 84 · see citing works
Lillioja, S., Neal, A. L., Tapsell, L. C., & Jacobs, D. R. (2013) · BioFactors · doi:10.1002/biof.1077 · Cited by 81 · see citing works
Balupillai, A., Prasad, N. R., Ramasamy, K., Govindasamy, K., & Muthusamy, G. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.05.030 · Cited by 81 · see citing works
Balupillai, A., Prasad, N. R., Ramasamy, K., Muthusamy, G., Shanmugham, M., Govindasamy, K., & Gunaseelan, S. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12522 · Cited by 81 · see citing works
Mária, J., & Ingrid, Ž. (2017) · Food & Function · doi:10.1039/c7fo00161d · Cited by 71 · see citing works
Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells
Ryšavá, A., Vostálová, J., & Svobodová, A. R. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1962566 · Cited by 65 · see citing works
Zhou, Z., Shi, T., Hou, J., & Li, M. (2020) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2020.1733012 · Cited by 64 · see citing works
Baião, D. D. S., Freitas, C. D., Gomes, L. P., Silva, D. D., Corrêa, A. C. N. T. F., Pereira, P. R., Aguila, E. M. D., & Paschoalin, V. M. F. (2017) · Nutrients · doi:10.3390/nu9091044 · Cited by 62 · see citing works
Carrara, M., Kelly, M. T., Roso, F., Larroque, M., & Margout, D. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c00296 · Cited by 60 · see citing works
Taofiq, O., Heleno, S. A., Calhelha, R. C., Fernandes, I. P., Alves, M. J., Barros, L., Gonzaléz‐Paramás, A. M., Ferreira, I. C. F. R., & Barreiro, M. F. (2019) · Microchemical Journal · doi:10.1016/j.microc.2019.03.059 · Cited by 59 · see citing works
Puigventós, L., Navarro‐Reig, M., Alechaga, É., Núñez, Ó., Saurina, J., Hernández‐Cassou, S., & Puignou, L. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8298-2 · Cited by 55 · see citing works
Beer and beer compounds: physiological effects on skin health
Chen, W., Becker, T. M., Qian, F., & Ring, J. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12204 · Cited by 54 · see citing works
UVA-photoprotective potential of silymarin and silybin
Svobodová, A. R., Gabrielová, E., Michaelides, L., Kosina, P., Ryšavá, A., Jitka Ulrichová, A., Zálešák, B., & Vostálová, J. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1828-6 · Cited by 54 · see citing works
Sharma, R., & Padwad, Y. S. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.02.004 · Cited by 55 · see citing works
Plant phenolics with promising therapeutic applications against skin disorders: A mechanistic review
Nisa, R. U., Nisa, A. U., Tantray, A. Y., Shah, A. H., Jan, A. T., Shah, A. A., & Wani, I. A. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101090 · Cited by 62 · see citing works
Jeon, J., Sung, J., Lee, H., Kim, Y., Jeong, H. S., & Lee, J. (2018) · Journal of Food Biochemistry · doi:10.1111/jfbc.12701 · Cited by 48 · see citing works
Salesa, B., Serra, R. S. I., & Serrano‐Aroca, Á. (2021) · Biology · doi:10.3390/biology10111072 · Cited by 45 · see citing works
Gupta, K. M., Das, S., Chow, P. S., & MacBeath, C. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c00717 · Cited by 44 · see citing works
Therapeutic potential of cranberry for kidney health and diseases
Amin, R., Thalluri, C., Docea, A. O., Sharifi‐Rad, J., & Călina, D. C. (2022) · eFood · doi:10.1002/efd2.33 · Cited by 42 · see citing works
Effect of UVA radiation on the Nrf2 signalling pathway in human skin cells
Ryšavá, A., Čížková, K., Franková, J., Roubalová, L., Jitka Ulrichová, A., Vostálová, J., Vrba, J., Zálešák, B., & Svobodová, A. R. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111948 · Cited by 41 · see citing works
Salesa, B., Assis, M., Andrés, J., & Serrano‐Aroca, Á. (2021) · Biomedicines · doi:10.3390/biomedicines9091155 · Cited by 40 · see citing works
Torres-Contreras, A. M., Garcia-Baeza, A., Vidal-Limon, H. R., Balderas-Renteria, I., Ramírez-Cabrera, M. A., & Ramirez-Estrada, K. (2022) · Plants · doi:10.3390/plants11020220 · Cited by 46 · see citing works
Li, F., Ding, Z., Chen, X. Z., Zhang, Y., Ke, W., Zhang, X., Li, Z. Q., Usman, S., & Guo, X. (2021) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2021.114835 · Cited by 37 · see citing works
Caffeic acid and licochalcone A interfere with the glyoxylate cycle of Trichophyton rubrum
Cantelli, B. A. M., Bitencourt, T. A., Komoto, T. T., Beleboni, R. O., Marins, M., & Fachin, A. L. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.051 · Cited by 37 · see citing works
Raj, P. S., Swapna, S. U. S., & Raghu, K. G. (2019) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12452 · Cited by 35 · see citing works
Valorization of pineapple waste as novel source of nutraceuticals and biofunctional compounds
Polanía, A. M., Londoño‐Hernández, L., Ramírez‐Toro, C., Bolívar, G., & Aguilar, C. N. (2022) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-022-02811-8 · Cited by 35 · see citing works
Comparison of Antiaging and Antioxidant Activities of Protocatechuic and Ferulic Acids
Girsang, E., Lister, I. N. E., Ginting, C. N., Bethasari, M., Amalia, A., & Widowati, W. (2020) · Molecular and Cellular Biomedical Sciences · doi:10.21705/mcbs.v4i2.90 · Cited by 34 · see citing works
Lonicera caerulea fruits reduce UVA-induced damage in hairless mice
Vostálová, J., Galandáková, A., Palíková, I., Jitka Ulrichová, A., Doležal, D., Lichnovská, R., Vrbková, J., & Svobodová, A. R. (2013) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2013.07.024 · Cited by 34 · see citing works
Widowati, W., Prahastuti, S., Ekayanti, N. L. W., Munshy, U. Z., Kusuma, H. S. W., Wibowo, S. H. B., Amalia, A., Widodo, W. S., & Rizal, R. (2019) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1374/1/012052 · Cited by 34 · see citing works
Callizot, N., Campanari, M., Rouvière, L., Jacquemot, G., Henriques, A. T., Garayev, E., & Poindron, P. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.681532 · Cited by 34 · see citing works
An oil‐soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells
Tito, A., Bimonte, M., Carola, A., Lucia, A. D., Barbulova, A., Tortora, A., Colucci, G., & Apone, F. (2015) · International Journal of Cosmetic Science · doi:10.1111/ics.12236 · Cited by 33 · see citing works
Liu, Y.-H., Lin, Y.-S., Huang, Y.-W., Fang, S.-U., Lin, S.-Y., & Hou, W. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b01196 · Cited by 32 · see citing works
Markiewicz, E., & Idowu, O. C. (2019) · Open Biology · doi:10.1098/rsob.190208 · Cited by 32 · see citing works
Ultraviolet A protective potential of plant extracts and phytochemicals
Škařupová, D., Vostálová, J., & Svobodová, A. R. (2020) · Biomedical Papers · doi:10.5507/bp.2020.010 · Cited by 32 · see citing works
Cranberries – potential benefits in patients with chronic kidney disease
Alvarenga, L., Borges, N. A., Moreira, L. D. S. G., Teixeira, K. T. R., Carraro-Eduardo, J. C., Dai, L., Stenvinkel, P., Lindholm, B., & Mafra, D. (2019) · Food & Function · doi:10.1039/c9fo00375d · Cited by 31 · see citing works
Yun, M.-S., Kim, C., & Hwang, J. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1908.08020 · Cited by 31 · see citing works
Lohakul, J., Jeayeng, S., Chaiprasongsuk, A., Torregrossa, R., Wood, M. E., Saelim, M., Thangboonjit, W., Whiteman, M., & Panich, U. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8255 · Cited by 29 · see citing works
Self-citationPark, G., Kim, H. G., Hong, S., Kim, S. Y., & Oh, M. S. (2014) · Skin Pharmacology and Physiology · doi:10.1159/000354917 · Cited by 29 · see citing works
Kamila, M. Z., & Helena, R. (2020) · Dermatologic Therapy · doi:10.1111/dth.14000 · Cited by 27 · see citing works
ObtainingAntioxidants from Botanic Matrices Applying Novel Extraction Techniques
Moraes, M. N., Zabot, G. L., Prado, J. M., & Meireles, M. A. A. (2013) · Food and public health · doi:10.5923/j.fph.20130304.04 · Cited by 28 · see citing works
Zduńska‐Pęciak, K., Kołodziejczak, A., & Rotsztejn, H. (2022) · Dermatologic Therapy · doi:10.1111/dth.15254 · Cited by 28 · see citing works
Seo, S. A., Ngo, H. T. T., Hwang, E., Park, B., & Yi, T. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.03.019 · Cited by 28 · see citing works
Onkoksoong, T., Jeayeng, S., Poungvarin, N., Limsaengurai, S., Thamsermsang, O., Tripatara, P., Akarasereenont, P., & Panich, U. (2018) · Phytotherapy Research · doi:10.1002/ptr.6083 · Cited by 25 · see citing works
Self-citationTaofiq, O., Barreiro, M. F., & Ferreira, I. C. F. R. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200402100157 · Cited by 26 · see citing works
Therapeutic potential of ferulic acid and its derivatives in Alzheimer’s disease—A systematic review
Phadke, A. V., Tayade, A. A., & Khambete, M. (2021) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13922 · Cited by 25 · see citing works
Liu, M., Liu, D., Yu, C.-L., Fan, H., Zhao, X. S., Wang, H., Zhang, C., Zhang, M., Bo, R., He, S., et al. (2023) · MedComm · doi:10.1002/mco2.255 · Cited by 24 · see citing works
Lohakul, J., Chaiprasongsuk, A., Jeayeng, S., Saelim, M., Muanjumpon, P., Thanachaiphiwat, S., Tripatara, P., Soontrapa, K., Lumlerdkij, N., Akarasereenont, P., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.649820 · Cited by 24 · see citing works
Self-citationBioactive compounds from Actinidia arguta fruit as a new strategy to fight glioblastoma
Macedo, C., Costa, P. C., & Rodrigues, F. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113770 · Cited by 23 · see citing works
Parets, L., Alechaga, É., Núñez, Ó., Saurina, J., Hernández‐Cassou, S., & Puignou, L. (2016) · Analytical Methods · doi:10.1039/c6ay00929h · Cited by 21 · see citing works
Chaisiriwong, L., Wanitphakdeedecha, R., Sitthinamsuwan, P., Sampattavanich, S., Chatsiricharoenkul, S., Manuskiatti, W., & Panich, U. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5934024 · Cited by 20 · see citing works
Self-citationSystemic Oxidative Stress Parameters in Skin Cancer Patients and Patients with Benign Lesions
Karampinis, E., Nechalioti, P.-M., Georgopoulou, K.-E., Goniotakis, G., Schulze, A. V. R., Zafiriou, E., & Kouretas, D. (2023) · Stresses · doi:10.3390/stresses3040054 · Cited by 20 · see citing works
Szulc-Kiełbik, I., Kiełbik, M., & Klink, M. (2017) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2017.1369100 · Cited by 20 · see citing works
Sun, G., Wang, J., Xu, X., Zhai, L., Li, Z., Liu, J., Zhao, D., Jiang, R., & Sun, L. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115883 · Cited by 19 · see citing works
Sodhi, G. K., Kaur, G., George, N., Walia, H. K., Sillu, D., Rath, S. K., Saxena, S., Rios‐Solis, L., & Dwibedi, V. (2024) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2024.06.059 · Cited by 19 · see citing works
Ginting, C. N., Lister, I. N. E., Girsang, E., Widowati, W., Yusepany, D. T., Azizah, A. M., & Kusuma, H. S. W. (2021) · Heliyon · doi:10.1016/j.heliyon.2020.e05620 · Cited by 19 · see citing works
Salesa, B., & Serrano‐Aroca, Á. (2021) · Coatings · doi:10.3390/coatings11040414 · Cited by 19 · see citing works
Ferulic acid – A novel topical agent in reducing signs of photoaging
Zduńska‐Pęciak, K., Dębowska, R., Kołodziejczak, A., & Rotsztejn, H. (2022) · Dermatologic Therapy · doi:10.1111/dth.15543 · Cited by 31 · see citing works
Non-Melanoma Skin Cancer: Assessing the Systemic Burden of the Disease
Karampinis, E., Koumaki, D., Sgouros, D., Nechalioti, P.-M., Toli, O., Pappa, G., Papadakis, M., Georgopoulou, K.-E., Schulze-Roussaki, A.-V., & Kouretas, D. (2025) · Cancers · doi:10.3390/cancers17040703 · Cited by 18 · see citing works
New insights into the therapeutic effects of phenolic acids from sorghum seeds
Nhiri, M., Mrid, R. B., Bouargalne, Y., & Omari, R. E. (2019) · Journal of Reports in Pharmaceutical Sciences · doi:10.4103/jrptps.jrptps_6_18 · Cited by 17 · see citing works
Figat, R., Śliwińska, A. A., Stochmal, A., Soluch, A., Sobczak, M., Zgadzaj, A., Sykłowska-Baranek, K., & Pietrosiuk, A. (2020) · Molecules · doi:10.3390/molecules25051090 · Cited by 16 · see citing works
Kim, H. K. (2016) · Nutrition Research and Practice · doi:10.4162/nrp.2016.10.4.371 · Cited by 16 · see citing works
The Anti-Acne Potential and Chemical Composition of Two Cultivated Cotoneaster Species
Krzemińska, B., Dybowski, M. P., Klimek, K., Typek, R., Miazga‐Karska, M., & Szewczyk, K. D. S. (2022) · Cells · doi:10.3390/cells11030367 · Cited by 15 · see citing works
Yang, T., Lai, Y., Lin, T.-P., Liu, W., Kuan, L.-C., & Liu, C. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15021686 · Cited by 14 · see citing works
Chiang, H., Chen, C.-W., Chen, C., Wang, H.-W., Jhang, J.-H., Huang, Y.-H., & Wen, K. (2014) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-12-409517-5.00058-9 · Cited by 13 · see citing works
Kim, S.-Y., Hong, M., Deepa, P., Sowndhararajan, K., Park, S. J., Park, S., & Kim, S. (2023) · Scientia Pharmaceutica · doi:10.3390/scipharm91010014 · Cited by 11 · see citing works
Biological Activities of Cosmetic Material from Ten Kinds of Flower Ethanol Extracts
Lee, T., So, Y. K., Kim, S. Y., & Hwang, J. Y. (2020) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2020.28.4.260 · Cited by 11 · see citing works
Wu, Y., Du, L., Xu, X., Hu, Y., Liu, J., Zhang, J., Lei, L., He, W., Sheng, Z., Ni, Y., et al. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c00861 · Cited by 10 · see citing works
García‐Villegas, A., Fernández‐Ochoa, Á., Alañón, M. E., Rojas-García, A., Arraéz-Román, D., Cádiz‐Gurrea, M. D. L. L., & Segura‐Carretero, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073723 · Cited by 11 · see citing works
Use of Natural Components Derived from Oil Seed Plants for Treatment of Inflammatory Skin Diseases
Styrczewska, M., Żuk, M., Boba, A., Zalewski, I., & Kulma, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190716111700 · Cited by 9 · see citing works
Phenolic Compounds in Prevention and Treatment of Skin Cancers: A Review
Gado, F., Digiacomo, M., Salsano, J. E., Macchia, M., & Manera, C. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210324160324 · Cited by 9 · see citing works
Pluemsamran, T., Tripatara, P., Phadungrakwittaya, R., Akarasereenont, P., Laohapand, T., & Panich, U. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/739473 · Cited by 9 · see citing works
Self-citationAsano, M., & Iwahashi, H. (2014) · Molecules · doi:10.3390/molecules190812486 · Cited by 9 · see citing works
Darzé, F. M., Bridi, E. C., França, F., Amaral, F., Turssi, C., & Basting, R. T. (2023) · Operative Dentistry · doi:10.2341/21-143-l · Cited by 8 · see citing works
Saechan, C., Nguyen, U. H., Wang, Z., Sugimoto, S., Yamano, Y., Matsunami, K., Otsuka, H., Giang, P. M., Viet, P. H., Tipmanee, V., et al. (2021) · PeerJ · doi:10.7717/peerj.11618 · Cited by 8 · see citing works
Avances en fotoprotección. Mecanismos moleculares implicados
Reyes, E., & Vitale, M. A. (2012) · Piel · doi:10.1016/j.piel.2012.04.011 · Cited by 8 · see citing works
Do wearing masks and preservatives have a combined effect on skin health?
Liu, Y., Chen, L., Zhang, S., Wang, X., Song, Y., Sun, H., Cai, Z., & Wang, L. (2024) · Eco-Environment & Health · doi:10.1016/j.eehl.2024.01.003 · Cited by 7 · see citing works
de Oliveira, M., Lang, G. H., Raphaelli, C. D. O., & Lovegrove, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822923-1.00029-7 · Cited by 7 · see citing works
Rathore, D., Naha, N., & Singh, S. (2024) · Springer eBooks · doi:10.1007/978-981-99-3334-1_21 · Cited by 7 · see citing works
Cimmino, G., Nisco, M. D., Alonso, C., Gravina, C., Piscopo, V., Lemos, R., Coderch, L., Piccolella, S., Pacifico, S., & Pedatella, S. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100240 · Cited by 6 · see citing works
Yao, J., Liu, Y., Lin, H., Shao, C., Jin, X., Peng, T., & Liu, Y. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111325 · Cited by 6 · see citing works
Krzemińska, B., Dybowski, M. P., Klimek, K., Typek, R., Miazga‐Karska, M., Ginalska, G., & Szewczyk, K. D. S. (2022) · Molecules · doi:10.3390/molecules27092907 · Cited by 6 · see citing works
- Authors
- Pluemsamran, T., Onkoksoong, T., & Panich, U.
- Affiliations
- Siriraj Hospital (TH)
- Corresponding author
- Panich, Uraiwan
- ORCID
- Panich, Uraiwan
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2012-04-20
- Volume
- 88
- Issue
- 4
- Pages
- 961-968
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2045951593
- Cited by
- 140
- References
- 31
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 22 · 2020: 13 · 2019: 13 · 2018: 8 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 6 · 2012: 1
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- caffeic acid, ferulic acid, UVA, MMP-1, keratinocytes, HaCaT keratinocytes, skin aging, oxidative stress, antioxidant defense, glutathione, gamma-glutamylcysteine synthetase, catalase, glutathione peroxidase, collagen degradation, phenolic antioxidants
- MeSH terms
- Antioxidants, Caffeic Acids, Catalase, Cell Line, Transformed, Coumaric Acids, Glutamate-Cysteine Ligase, Gene Expression Regulation, Glutathione, Glutathione Peroxidase, Humans, RNA, Messenger, Ultraviolet Rays, Skin Aging, Keratinocytes, Oxidative Stress, Matrix Metalloproteinase 1, Matrix Metalloproteinase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review