The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Vascular Endothelial Growth Factor: An Essential Component of Angiogenesis and Fracture Healing
Open accessAbstract
Fractures require adequate stability and blood supply to heal. The vascular supply to long bones is compromised in a fracture, and the ability to heal hinges on the ability of new blood vessels to proliferate from surrounding vessels in a process known as angiogenesis. This process is largely driven by the growth factor, vascular endothelial growth factor (VEGF), whose levels are increased locally and systemically during fracture healing. VEGF is involved in many steps throughout the fracture healing cascade, from initially being concentrated in fracture hematoma, to the promotion of bone turnover during the final remodeling phase. This article reviews the current literature surrounding the role of VEGF and other growth factors in reestablishing vascular supply to fractured bone, as well as medications and surgical techniques that may inhibit this process.
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Citations
Cites
The biology of VEGF and its receptors
Ferrara, N., Gerber, H.-P., & LeCouter, J. (2003) · Nature Medicine · doi:10.1038/nm0603-669 · Cited by 9,591
Kon, T., Cho, T.-J., Aizawa, T., Yamazaki, M., Nooh, N., Graves, D., Gerstenfeld, L. C., & Einhorn, T. A. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.6.1004 · Cited by 552
Overview of the fracture healing cascade
Phillips, A. M. (2005) · Injury · doi:10.1016/j.injury.2005.07.027 · Cited by 311
Wang, D. S., Miura, M., Demura, H., & Sato, K. (1997) · Endocrinology · doi:10.1210/endo.138.7.5275 · Cited by 254
Chemotaxis of human articular chondrocytes and mesenchymal stem cells
Mishima, Y., & Lotz, M. (2008) · Journal of Orthopaedic Research · doi:10.1002/jor.20668 · Cited by 192
Aspenberg, P. (2005) · Acta Orthopaedica · doi:10.1080/17453670510045318 · Cited by 97
Cited by
Blood vessel formation and function in bone
Sivaraj, K. K., & Adams, R. H. (2016) · Development · doi:10.1242/dev.136861 · Cited by 441
Lee, H. Y., Kim, D.-S., Hwang, G. Y., Lee, J.-K., Lee, H.-L., Jung, J.-W., Hwang, S. Y., Baek, S.-W., Yoon, S. L., Ha, Y., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100611 · Cited by 31
Orth, M., Fritz, T., Stutz, J., Scheuer, C., Ganse, B., Bullinger, Y., Lee, J. S., Murphy, W. L., Laschke, M. W., Menger, M. D., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.809397 · Cited by 15
Metadata
- Authors
- Beamer, B., Hettrich, C., & Lane, J.
- Venue
- HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery
- Publisher
- SAGE Publications
- Published
- 2010-02
- Volume
- 6
- Issue
- 1
- Pages
- 85-94
- ISSN
- 1556-3316 (ISSN-L)
- 1556-3324
- OpenAlex
- W2060416200
- Cited by
- 161
- References
- 6
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Beamer, B., Hettrich, C., & Lane, J. (2010). Vascular Endothelial Growth Factor: An Essential Component of Angiogenesis and Fracture Healing. HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery. https://doi.org/10.1007/s11420-009-9129-4
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