Drugs and fracture repair

Aspenberg, Per

doi:10.1080/17453670510045318

Cited by 97Bone fractures and treatmentsBone health and osteoporosis researchBone Tissue Engineering Materials

Drugs and fracture repair

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Aspenberg, Per·2005·Acta Orthopaedica

DOI 10.1080/17453670510045318

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Abstract

The repair of long bones has not been optimized by Mother Nature. One would think that such a complicated process, leading to replacement of damaged tissue and restoration of function, would be the...

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In a review, Per Aspenberg listed drugs that improve fracture healing: growth factors (FGF 1 and 2, TGF-1, GH, BMPs), PTH, selective prostaglandin agonists, statins, and beta blockers.
“The drugs he listed that improve fracture healing were growth factors (fibroblast growth factors (FGF) 1 and 2, transforming growth factor 1 (TGF-1), growth hormone (GH), and bone morphogenetic proteins (BMPs)), PTH, selective prostaglandin agonists, statins, and beta blockers.”
From Methods to accelerate fracture healing – a narrative review from a clinical perspective (2024) · cites this paper as [84]
The growth-factors section (p. 3) reports benefits for FGF-2 and GH in animal studies, but does not identify FGF-1 as improving fracture repair; it discusses TGF-β in combination with IGF-1 rather than as a demonstrated benefit on its own. The Conclusion (p. 6) supports BMPs, PTH and selective prostaglandin agonists. The statins and beta-blockers section (p. 5) reports limited positive animal findings while emphasizing inconsistent or failed results, so the unqualified list overstates the review. (LLM, conf=0.88)
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Authors: Aspenberg, P.
Affiliations: Linköping University (SE)
Corresponding author: Aspenberg, Per
Venue: Acta Orthopaedica
Publisher: MJS Publishing, Medical Journals Sweden AB
Published: 2005-01
Volume: 76
Issue: 6
Pages: 741-748
ISSN: 1745-3674 (ISSN-L)
1745-3682
DOI: 10.1080/17453670510045318
OpenAlex: W2094654701
Cited by: 97
References: 65
Citations by year: 2025: 1 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 2 · 2012: 5
FWCI: 1.21
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Acta Orthopaedica (publishedVersion)
Acta Orthopaedica (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords: fracture healing, bone regeneration, long bones, drugs, osteoporosis
MeSH terms: Adrenal Cortex Hormones, Adrenergic beta-Antagonists, Animals, Anti-Bacterial Agents, Anticholesteremic Agents, Anticoagulants, Antineoplastic Agents, Fibrinolytic Agents, Growth Substances, Humans, Osteogenesis, Parathyroid Hormone, Receptors, Prostaglandin, Cyclooxygenase Inhibitors, Fracture Healing, Bone Morphogenetic Proteins, Cell Proliferation

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