The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells
Abstract
The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in the regulation of not only brain function but also the regulation of the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are suppressed by these agents leading to the hypothesis that these drugs may be of value in the management of chronic inflammatory diseases. In this report, we review current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs.
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“Cannabinoids also inhibit the cell-specific proliferation of B and T cells (Cabral and Griffin-Thomas, 2009;Klein and Cabral, 2006).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Klein and Cabral, 2006
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Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry
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Metadata
- Authors
- Klein, T. W., & Cabral, G. A.
- Affiliations
- University of South Florida (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Klein, Thomas W.
- ORCID
- Klein, Thomas W.
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2006-02-22
- Volume
- 1
- Issue
- 1
- Pages
- 50-64
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- OpenAlex
- W2061663043
- Cited by
- 172
- References
- 139
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 12 · 2020: 16 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 13 · 2012: 6
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmune Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA15608, DA05832, R01DA003646, DA03646, R01DA015608)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- cannabinoids, endocannabinoid system, immunosuppression, antigen-presenting cells, cannabinoid receptors, cytokines, chronic inflammatory diseases, immunomodulation
- MeSH terms
- Animals, Antigen-Presenting Cells, Cannabinoids, Cannabis, Humans, Inflammation, Receptors, Cannabinoid
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