Cited by 172Cannabis and Cannabinoid ResearchImmunotoxicology and immune responsesInflammatory mediators and NSAID effects

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Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells

Klein, Thomas W., Cabral, Guy A.·2006·Journal of Neuroimmune Pharmacology

DOI 10.1007/s11481-005-9007-x

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Abstract

The study of marijuana cannabinoid biology has led to many important discoveries in neuroscience and immunology. These studies have uncovered a new physiological system, the endocannabinoid system, which operates in the regulation of not only brain function but also the regulation of the immune system. Studies examining the effect of cannabinoid-based drugs on immunity have shown that many cellular and cytokine mechanisms are suppressed by these agents leading to the hypothesis that these drugs may be of value in the management of chronic inflammatory diseases. In this report, we review current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic potential of cannabinoid-based drugs.

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Authors: Klein, T. W., & Cabral, G. A.
Affiliations: University of South Florida (US)
Virginia Commonwealth University (US)
Corresponding author: Klein, Thomas W.
ORCID: Klein, Thomas W.
Venue: Journal of Neuroimmune Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 2006-02-22
Volume: 1
Issue: 1
Pages: 50-64
ISSN: 1557-1890 (ISSN-L)
1557-1904
DOI: 10.1007/s11481-005-9007-x
OpenAlex: W2061663043
Cited by: 172
References: 139
Citations by year: 2026: 4 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 12 · 2020: 16 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 13 · 2015: 6 · 2014: 9 · 2013: 13 · 2012: 6
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Neuroimmune Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA15608, DA05832, R01DA003646, DA03646, R01DA015608)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: cannabinoids, endocannabinoid system, immunosuppression, antigen-presenting cells, cannabinoid receptors, cytokines, chronic inflammatory diseases, immunomodulation
MeSH terms: Animals, Antigen-Presenting Cells, Cannabinoids, Cannabis, Humans, Inflammation, Receptors, Cannabinoid

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Cannabinoid-Induced Immune Suppression and Modulation of Antigen-Presenting Cells

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