The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
Opioid Drug Abuse and Modulation of Immune Function: Consequences in the Susceptibility to Opportunistic Infections
Open accessAbstract
Infection rate among intravenous drug users (IDU) is higher than the general public, and is the major cause of morbidity and hospitalization in the IDU population. Epidemiologic studies provide data on increased prevalence of opportunistic bacterial infections such as TB and pneumonia, and viral infections such as HIV-1 and hepatitis in the IDU population. An important component in the intravenous drug abuse population and in patients receiving medically indicated chronic opioid treatment is opioid withdrawal. Data on bacterial virulence in the context of opioid withdrawal suggest that mice undergoing withdrawal had shortened survival and increased bacterial load in response to Salmonella infection. As the body of evidence in support of opioid dependency and its immunosuppressive effects is growing, it is imperative to understand the mechanisms by which opioids exert these effects and identify the populations at risk that would benefit the most from the interventions to counteract opioid immunosuppressive effects. Thus, it is important to refine the existing animal model to closely match human conditions and to cross-validate these findings through carefully controlled human studies. Better understanding of the mechanisms will facilitate the search for new therapeutic modalities to counteract adverse effects including increased infection rates. This review will summarize the effects of morphine on innate and adaptive immunity, identify the role of the mu opioid receptor in these functions and the signal transduction activated in the process. The role of opioid withdrawal in immunosuppression and the clinical relevance of these findings will also be discussed.
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Cited by
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Self-citationAslam, H., Green, J., Jacka, F. N., Collier, F., Berk, M., Pasco, J., & Dawson, S. L. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1544332 · Cited by 179
Contribution of behavioral health factors to non-AIDS-related comorbidities: an updated review
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The effect of opioid dependence on conventional and novel biochemical parameters of bone metabolism
Balodimos, S., Nikolaou, K., Njau, S., Karamouzis, M., & Kovatsi, L. (2015) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2015.1068321 · Cited by 9
Metadata
- Authors
- Roy, S., Ninkovic, J., Banerjee, S., Charboneau, R. G., Das, S., Dutta, R., Kirchner, V. A., Koodie, L., Ma, J., Meng, J., & Barke, R. A.
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2011-07-26
- Volume
- 6
- Issue
- 4
- Pages
- 442-465
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- OpenAlex
- W2094224794
- Cited by
- 309
- References
- 174
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Roy, S., Ninkovic, J., Banerjee, S., Charboneau, R. G., Das, S., Dutta, R., Kirchner, V. A., Koodie, L., Ma, J., Meng, J., & Barke, R. A. (2011). Opioid Drug Abuse and Modulation of Immune Function: Consequences in the Susceptibility to Opportunistic Infections. Journal of Neuroimmune Pharmacology. https://doi.org/10.1007/s11481-011-9292-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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