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Cited by 83T-cell and B-cell ImmunologyWnt/β-catenin signaling in development and cancerPsoriasis: Treatment and Pathogenesis

β-Catenin/TCF-1 Pathway in T Cell Development and Differentiation

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Ma, Jian, Wang, Ruiqing, Fang, Xianfeng, Sun, Zuoming·2012·Journal of Neuroimmune Pharmacology
DOI 10.1007/s11481-012-9367-yPMC PMC3582214
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Abstract

T cells must undergo two critical differentiation processes before they become competent effectors that can mediate actual immune responses. Progenitor T cells undergo defined stages of differentiation in the thymus, which include positive and negative selection, to generate a repertoire of T cells that will respond to foreign but not self antigens. When these immunocompetent T cells first migrate out of thymus into peripheral lymphoid tissues, they are naïve and are unable to mediate immune responses. However, upon antigen encounter, peripheral CD4+ naïve T cells undergo another differentiation process to become armed effector T cells including Th1, Th2, Th17 or regulatory T cells, all of which are capable of regulating immune responses. A canonical Wnt/β-catenin/T cell factor (TCF) pathway has been shown to regulate T cell differentiation in both the thymus and in peripheral lymphoid tissues. Dysfunction of this pathway at any stage of T cell differentiation could lead to severe autoimmunity including experimental autoimmune encephalomyelitis or immune deficiency. Understanding the role played by β-catenin/TCF-1 in T cell differentiation will facilitate our understanding of the mechanisms that regulate T cell function and assist in identifying novel therapy targets for treating both autoimmune and immune diseases. Therefore, in this review, we will focus on the function of β-catenin/TCF-1 pathway in the regulation of thymic and peripheral T cell differentiation processes.

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  • The Wnt signalling pathway is an important regulator in all developmental stages of T-cells.

    “Furthermore, with regard to T-cell development, the Wnt signalling pathway has been described as an important regulator in all developmental stages of T-cells [42,43,44].”

    From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [42]

    Section 3.2 describes Wnt signalling as indispensable for thymocyte development and says it regulates multiple processes at multiple stages. It does not say it regulates all stages; section 3.3 identifies DN2 proliferation as the earliest point at which its regulatory role is reported. (LLM, conf=0.85)

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Cited by

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Authors
Ma, J., Wang, R., Fang, X., & Sun, Z.
Affiliations
City Of Hope National Medical Center (US)
Corresponding author
Sun, Zuoming
ORCID
Venue
Journal of Neuroimmune Pharmacology
Publisher
Springer Science and Business Media LLC
Published
2012-04-27
Volume
7
Issue
4
Pages
750-762
ISSN
  • 1557-1890 (ISSN-L)
  • 1557-1904
DOI
10.1007/s11481-012-9367-y
PMC
PMC3582214
OpenAlex
W2044903635
Cited by
83
References
6
Citations by year
2026: 6 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
0.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroimmune Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R56AI072554, R01AI053147)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
Wnt signaling, T cell differentiation, thymic selection, positive selection, negative selection, naive T cells, effector T cell differentiation, Th1 cells, Th2 cells, Th17 cells, regulatory T cells, autoimmunity, experimental autoimmune encephalomyelitis, immunodeficiency
MeSH terms
Animals, Cell Differentiation, Humans, T-Lymphocytes, Cell Proliferation, beta Catenin, T Cell Transcription Factor 1, Wnt Signaling Pathway

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