Cited by 1,014T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Pearce, Erika L., Mullen, Alan C., Martins, Gislâine A., Krawczyk, Connie M., Hutchins, Anne S., Zediak, Valerie P., Banica, Monica, DiCioccio, Catherine B. +9 more·2003·Science

Abstract

Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8 + T cells. We now show that Eomesodermin ( Eomes ), a paralogue of T-bet , is induced in effector CD8 + T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8 + T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8 + T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.

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Crossref · 10.1126/science.1090148

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Authors
Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., Shen, H., Cereb, N., Yang, S. Y., Lindsten, T., Rossant, J., Hunter, C. A., & Reiner, S. L.
Affiliations
  • Mount Sinai Hospital (CA)
  • Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Corresponding author
Reiner, Steven L.
Venue
Science
Published
2003-11-07
Volume
302
Issue
5647
Pages
1041-1043
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2119319172
Cited by
1,014
References
18
Citations by year
2026: 25 · 2025: 36 · 2024: 32 · 2023: 47 · 2022: 45 · 2021: 72 · 2020: 60 · 2019: 49 · 2018: 63 · 2017: 33 · 2016: 50 · 2015: 45 · 2014: 56 · 2013: 69 · 2012: 56
FWCI
8.86
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of General Medical Sciences (T32GM007229, GM-07229)
  • National Institute of Allergy and Infectious Diseases (AI 042370, R01AI042370)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
Eomesodermin, CD8+ T cells, effector T cell differentiation, transcription factors, T-bet, interferon-gamma, perforin, granzyme B, cell-mediated immunity, transcriptional regulation
MeSH terms
T-bet Transcription Factor, Amino Acid Sequence, Animals, Arenaviridae Infections, Base Sequence, Cell Differentiation, Cytotoxicity, Immunologic, Gene Expression Regulation, Interferon-gamma, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Membrane Glycoproteins, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, RNA, Messenger, Serine Endopeptidases, Transcription Factors, CD8-Positive T-Lymphocytes, Th2 Cells, T-Box Domain Proteins, Mice, Pore Forming Cytotoxic Proteins, Granzymes, Perforin

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