Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: A Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection

Holder, Gerard E.; McGary, Christopher M.; Johnson, Edward M.; Zheng, Rubo; John, Vijay T.; Sugimoto, Chie; Kuroda, Marcelo J.; Kim, Woong-Ki

doi:10.1007/s11481-014-9564-y

Expression of the Mannose Receptor CD206 in HIV and SIV Encephalitis: A Phenotypic Switch of Brain Perivascular Macrophages with Virus Infection

We examined the expression of the mannose receptor CD206 by perivascular macrophages (PVM) in normal human and monkey brains and in brains of HIV-infected humans and of monkeys infected with simian immunodeficiency virus (SIV). Depletion of brain PVM in SIV-infected monkeys by intrathecal injecti…