Novel aspects of the apolipoprotein-E receptor family: regulation and functional role of their proteolytic processing
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ApoER2 is proteolytically processed by secretases.
“Similarly to APP, ApoER2 is proteolytically processed by secretases [38].”
From Sorting nexin 17 regulates ApoER2 recycling and reelin signaling (2014) · cites this paper as [38]
Dab2, Fe65, and X11α/Mint bind to the ApoER2 cytoplasmic domain and regulate its trafficking and signaling.
“In addition to Dab1, a number of adaptors proteins, including Dab2, Fe65, and X11α/Mint, bind to the ApoER2 cytoplasmic domain and regulate its trafficking and signaling [38].”
From Sorting nexin 17 regulates ApoER2 recycling and reelin signaling (2014) · cites this paper as [38]
Cites
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“…function of this receptor is to trigger a signal transduction pathway following binding of reelin (Darcangelo et al., 1999), which is an extracellular matrix protein that is secreted in the developing brain and in the adult brain (Ogawa et al., 1995; Del Río et al., 1997; Bar and Goffinet, 1999).”
BackgroundMao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00224-6 · Cited by 839 · cited 2× · see citing works
“*JIP2 Stockinger et al., 2000 *PSD95 Gotthardt et al., 2000 *Talin homolog Gotthardt et al., 2000 *APC subunit 10 Gotthardt et al., 2000 *ICAP-1 Gotthardt et al., 2000 *X11/ He et al., 2007 Dab1 Trommsdorff et al., 1999 Fe65 Hoe et al., 2006 SNX17 Stockinger et al., 2002 Dab2 Cuitino et al., 2005 ARH Jones et al., 200…”
BackgroundIdentification of Vangl2 and Scrb1 as planar polarity genes in mammals
Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A., & Kelley, M. W. (2003) · Nature · doi:10.1038/nature01618 · Cited by 705 · see citing works
Slusarski, D. C., Corces, V. G., & Moon, R. T. (1997) · Nature · doi:10.1038/37138 · Cited by 680 · see citing works
Kuhn, P., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Roßner, S., & Lichtenthaler, S. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.167 · Cited by 621 · see citing works
Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works
Zeng, X., Huang, H., Tamai, K., Zhang, X., Harada, Y., Yokota, C., Almeida, K., Wang, J., Doble, B., Woodgett, J., et al. (2008) · Development · doi:10.1242/dev.013540 · Cited by 492 · see citing works
A role for Cajal–Retzius cells and reelin in the development of hippocampal connections
Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., et al. (1997) · Nature · doi:10.1038/385070a0 · Cited by 472 · see citing works
Rohlmann, A., Gotthardt, M., Hammer, R. E., & Herz, J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1240 · Cited by 455 · see citing works
Rice, D. S., Sheldon, M., D’Arcangelo, G., Nakajima, K., Goldowitz, D., & Curran, T. (1998) · Development · doi:10.1242/dev.125.18.3719 · Cited by 378 · see citing works
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W. J., & Nimpf, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004119200 · Cited by 239 · cited 7× · see citing works
“Some of these proteins, including JIP1/2 (Stockinger et al., 2000), PSD95 (Herz and Chen, 2006) and the adaptor protein X11α/βMint (He et al.”
BackgroundInfluentialPietrzik, C. U., Busse, T., Merriam, D. E., Weggen, S., & Koo, E. H. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf568 · Cited by 198 · see citing works
DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing
Hoe, H.-S., Tran, T. S., Matsuoka, Y., Howell, B. W., & Rebeck, G. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602162200 · Cited by 174 · see citing works
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FE65 interaction with the ApoE receptor ApoEr2
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Sorting nexin 17 regulates ApoER2 recycling and reelin signaling
Sotelo, P., Farfán, P., Benitez, M. L., Bu, G., & Marzolo, M.-P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093672 · Cited by 47 · see citing works
Self-citationNeurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
Larios, J. A., Jausoro, I., Benitez, M.-L., Bronfman, F. C., & Marzolo, M.-P. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-108 · Cited by 12 · see citing works
Self-citation
- Authors
- Larios, J. A., & Marzolo, M.-P.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- Venue
- Frontiers in Biology
- Published
- 2012-03-16
- Volume
- 7
- Issue
- 2
- Pages
- 113-143
- ISSN
- 1673-3509 (ISSN-L)
- 1674-7984
- 1674-7992
- OpenAlex
- W1984044963
- Cited by
- 9
- References
- 18
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Frontiers in Biology (publishedVersion)
- Frontiers in Biology
- Funders
- Fondo Nacional de Ciencia y Tecnología
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- proteolytic processing, ectodomain shedding, gamma-secretase, cytoplasmic domain, receptor internalization, apolipoprotein E, receptor regulation, Alzheimer's disease, Notch signaling
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