A role for Cajal–Retzius cells and reelin in the development of hippocampal connections
Abstract
During development of the nervous system, specific recognition molecules provide the cues necessary for the formation of neural connections. In some regions, guiding cues for axonal pathfinding and target selection are provided by specific cells that exist only transiently during development, such as the floorplate or the cortical subplate. In the hippocampus, distinct groups of fibres innervate different layers. We have tested the hypothesis that transient neurons in the hippocampus provide positional information for the targeting of these fibres. Here we report that ablation of Cajal-Retzius cells in organotypic slice cultures of hippocampus prevented the ingrowth of entorhinal but not of commissural afferents. Experiments inhibiting Reelin (an extracellular matrix protein expressed by Cajal-Retzius cells) and analysis of reeler mutant mice showed dramatic abnormalities in the development of entorhinal afferents. Thus Cajal-Retzius cells and reelin are essential for the formation of layer-specific hippocampal connections.
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CR-50 antibody has neutralizing activity of Reelin both in vitro and in vivo.
“The CR-50 antibody has neutralizing activity of Reelin both in vitro and in vivo (13, 19–21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [19]
The CR-50 epitope region is essential for Reelin functions.
“This epitope region is essential for the Reelin functions, because CR-50 antibody inhibits laminar pattern formation in cortical reaggregation cultures (13), Purkinje cell alignment in cerebellar explant cultures (20), and an axonal branching pattern in the entorhinohippocampal pathway in vitro (19) and disrupts hippocampal development in vivo (21).”
From Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody (2000) · cites this paper as [19]
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- Authors
- Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., Derer, P., Frotscher, M., & Soriano, E.
- Affiliations
- University of Freiburg (DE)
- Universitat de Barcelona (ES)
- RIKEN (JP)
- Kochi Medical School Hospital (JP)
- Université Pierre-et-Marie-Curie (FR)
- ORCID
- Venue
- Nature
- Published
- 1997-01
- Volume
- 385
- Issue
- 6611
- Pages
- 70-74
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2070651871
- Cited by
- 472
- References
- 26
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 10 · 2017: 11 · 2016: 17 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 11
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Cajal-Retzius cells, reelin, hippocampus, axon guidance, reeler mutant mice, organotypic slice cultures, extracellular matrix
- MeSH terms
- Reelin Protein, Animals, Antibodies, Monoclonal, Astrocytes, Axons, Hippocampus, Mice, Neurologic Mutants, Nerve Tissue Proteins, Neural Pathways, Neurons, Afferent, Serine Endopeptidases, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Entorhinal Cortex, Culture Techniques, Mice
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