Self-reported confusion is related to global and regional β-amyloid: data from the Women’s healthy ageing project
Open accessAbstract
Disease-modifying treatments for Alzheimer's disease (AD) may require implementation during early stages of β-amyloid accumulation, well before patients have objective cognitive decline. In this study we aimed to assess the clinical value of subjective cognitive impairment (SCI) by examining the cross-sectional relationship between β-amyloid load and SCI. Cerebral β-amyloid and SCI was assessed in a cohort of 112 cognitively normal subjects. Subjective cognition was evaluated using specific questions on memory and cognition and the MAC-Q. Participants had cerebral β-amyloid load measured with 18 F-Florbetaben Positron Emission Tomography (PET). No associations were found between measures of subjective memory impairment and cerebral β-amyloid. However, by self-reported confusion was predictive of a higher global β-amyloid burden (p = 0.002), after controlling for confounders. Regional analysis revealed significant associations of confusion with β-amyloid in the prefrontal region (p = 0.004), posterior cingulate and precuneus cortices (p = 0.004) and the lateral temporal lobes (p = 0.001) after controlling for confounders. An in vivo biomarker for AD pathology was associated with SCI by self-reported confusion on cross-sectional analysis. Whilst there has been a large body of research on SMC, our results indicate more research is needed to explore symptoms of confusion.
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- McCluskey, G. E., Yates, P., Villemagne, V. L., Rowe, C. & Szoeke, C. E. I. (2018). Self- reported confusion is related to global and regional beta-amyloid: data from the Women's healthy ageing project. BRAIN IMAGING AND BEHAVIOR, 12 (1), pp.78-86. https://doi.org/10.1007/s11682-016-9668-5. Persistent Link: http://hdl.handle.net/11343/219787 File Description: Accepted
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- Authors
- McCluskey, G. E., Yates, P., Villemagne, V. L., Rowe, C., & Szoeke, C. E. I.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Austin Health (AU)
- The University of Melbourne (AU)
- Corresponding author
- Szoeke, Cassandra E. I.
- Venue
- Brain Imaging and Behavior
- Published
- 2017-01-20
- Volume
- 12
- Issue
- 1
- Pages
- 78-86
- ISSN
- 1931-7557 (ISSN-L)
- 1931-7565
- OpenAlex
- W2572439149
- Cited by
- 7
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Brain Imaging and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- National Health and Medical Research Council (1062133, 547600, 1032350)
- Bayer Health
- Ramaciotti Foundation
- Brain Foundation
- Alzheimer's Association of Australia
- Australian Menopausal Society
- Shepherd Foundation
- Scobie and Claire McKinnon Foundation
- Collier Trust Fund
- JO and JR Wicking Trust
- Mason Foundation
- Alzheimer's Association (NIA320312)
- VicHealth
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- subjective cognitive impairment, amyloid-beta, Alzheimer's disease, prefrontal cortex, posterior cingulate cortex, precuneus, lateral temporal lobe, early detection of dementia
- MeSH terms
- Affect, Aged, Aging, Aniline Compounds, Brain, Confusion, Cross-Sectional Studies, Educational Status, Female, Humans, Longitudinal Studies, Perception, Stilbenes, Cohort Studies, Amyloid beta-Peptides, Radiopharmaceuticals, Positron-Emission Tomography, Apolipoprotein E4, Self Report, Diagnostic Self Evaluation, Cognitive Dysfunction
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