The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ursodeoxycholic Acid in the Prevention of Gallstone Formation after Bariatric Surgery: A Meta-analysis
Abstract
Background Rapid weight loss increases risk for gallstone formation. Prophylactic cholecystectomy is difficult. Several small trials have shown that ursodeoxycholic acid (UDCA) may prevent gallstone formation after bariatric surgery. The aim of this study is to assess the efficacy and safety of UDCA in the prevention of gallstone formation after bariatric surgery. Methods Electronic databases, including the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, Australasian Medical Index, LILACS, and HERDIN, were searched. Reference lists of trials selected by the above electronic searching were also searched. Authors of the retrieved trials and pharmaceutical companies were also contacted for other trials, published and unpublished. A meta-analysis of all randomized, double-blind, placebo-controlled prospective trials comparing UDCA and placebo was performed. Results Five RCTs including 521 patients were assessed. Random effects meta-analysis showed a significant reduction of gallstone formation (RR 0.43, 95% confidence interval 0.22-0.83), with 8.8% of those taking UDCA developing gallstones compared to 27.7% for placebo. Although this meta-analysis is heterogeneous with I(2) of 61.9%, the directions of the effect are all consistently in favor of UDCA (p=0.01). A meta-analysis on the adverse effects could not be performed because the studies did not report them in a way to make the analysis possible. Conclusions UDCA can prevent gallstone formation after bariatric…
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Ursodeoxycholic acid reduces the formation of cholesterol gallstones during rapid weight loss induced by very low-calorie diets or bariatric surgery.
“There is robust evidence that ursodeoxycholic acid reduces the formation of cholesterol gallstones during rapid weight loss induced by very low-calorie diets or bariatric surgery.6,14,15”
Citations
Cites
Miller, K., Hell, E., Lang, B., & Lengauer, E. (2003) · Annals of Surgery · doi:10.1097/01.sla.0000094305.77843.cf · Cited by 200
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Research works printed but not linked: 13
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- Sugerman HJ, Brewer WH, Shiffman ML, et al. A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursodiol for the prevention of gallstone formation following gastric-bypass-induced rapid weight loss. Am J Surg. 1995;169:91–7. · DOI · Paper page
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- Shiffman ML, Kaplan GD, Brinkman-Kaplan V, et al. Prophylaxis against gallstone formation with ursodeoxycholic acid in patients participating in a very-low-calorie diet program. Ann Int Med. 1995;122(12):899–905. · DOI · Paper page
- Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. J Am Med Assoc. 2004;292(14):1724–37. · DOI · Paper page
- Broomfield PH, Chopra R, Sheinbaum RC, et al. Effects of ursodeoxycholic acid and aspirin on the formation of lithogenic bile and gallstones during loss of weight. N Engl J Med. 1998;319(24):1567–72. · DOI · Paper page
- Lafferrere B, Heshka S, Wang K, et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes Care. 2007;30:1709–16. · DOI · Paper page
- Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordtran’s gastrointestinal and liver disease: pathophysiology/diagnosis/management. Philadelphia: Saunders Elsevier; 2006.
- Tan-Tin Hay LM, Oliveros E, Esguerra E, et al. A review of the metabolic profile of patients undergoing bariatric surgery in St. Luke’s Medical Center (2002–2004). Philipp J Int Med. 2005;43:323–30.
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Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
Mechanick, J. I., Youdim, A., Jones, D. B., Garvey, W. T., Hurley, D. L., McMahon, M. M., Heinberg, L. J., Kushner, R., Adams, T. D., Shikora, S., et al. (2013) · Obesity · doi:10.1002/oby.20461 · Cited by 1,650
Mechanick, J. I., Youdim, A., Jones, D. B., Garvey, W. T., Hurley, D. L., McMahon, M. M., Heinberg, L. J., Kushner, R., Adams, T. D., Shikora, S., et al. (2013) · Endocrine Practice · doi:10.4158/ep12437.gl · Cited by 395
Olbers, T., Beamish, A. J., Gronowitz, E., Flodmark, C.-E., Dahlgren, J., Bruze, G., Ekbom, K., Friberg, P., Göthberg, G., Järvholm, K., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30424-7 · Cited by 318
Stokes, C. S., Gluud, L. L., Casper, M., & Lammert, F. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.11.031 · Cited by 118
Magouliotis, D. E., Tasiopoulou, V. S., Svokos, A. A., Svokos, K. A., Chatedaki, C., Sioka, E., & Zacharoulis, D. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2924-y · Cited by 108
Haal, S., Guman, M. S. S., Boerlage, T. C. C., Acherman, Y. I. Z., de Brauw, L. M., Bruin, S., de Castro, S. M. M., van Hooft, J. E., van de Laar, A. W. J. M., Moes, D. E., et al. (2021) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(21)00301-0 · Cited by 82
Manatsathit, W., Leelasinjaroen, P., Al-Hamid, H., Szpunar, S., & Hawasli, A. (2016) · International Journal of Surgery · doi:10.1016/j.ijsu.2016.03.060 · Cited by 78
Metadata
- Authors
- Uy, M. C., Talingdan-Te, M. C., Espinosa, W. Z., Daez, M. L. O., & Ong, J. P.
- Venue
- Obesity Surgery
- Published
- 2008-06-24
- Volume
- 18
- Issue
- 12
- Pages
- 1532-1538
- ISSN
- 0960-8923
- 1708-0428
- Cited by
- 133
- References
- 1
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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