Long-term results of a prospective comparison of roux-en-y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population (bmi 35–50 kg/m2)
Abstract
Background This study presents late results of a previously published 2-year prospective comparison between Roux-en-Y gastric bypass (RYGBP) versus biliopancreatic diversion with Roux-en-Y gastric bypass (BPD-RYGBP) in an exclusively non-superobese population.Methods From a cohort of 130 patients with a BMI of 35-50 kg/m(2), 65 were randomly selected to undergo RYGBP and 65 to BPD-RYGBP. All underwent follow-up evaluation at 1, 3, 6, and 12 months postoperatively and every year thereafter.Results Follow-up at the eighth year was achieved in 60% of the BPD-RYGBP and in 58% of the RYGBP group (p = 1.00). Mean excess weight loss (EWL%), was significantly higher following BPD-RYGBP (76.89 ± 1.53) as compared to RYGBP (67.17 ± 1.43) (p = 0.0004). The mean success rate (percentage of patients with EWL% ≥50%) was significantly higher after BPD-RYGBP (95.85 ± 1.01) than RYGBP (75.91 ± 3.58) (p = 0.0001). No significant differences were observed for late non-metabolic complications. The incidence of anemia, iron deficiency, B12 deficiency, and low-ferritin levels was relatively high in both groups with not always significant differences. Severe protein malnutrition occurred in four patients (three BPD-RYGBP and one RYGBP) (p = 0.37). In only one BPD-RYGBP patient (1.54%) was revision surgery to RYGBP necessary, due to recurrent episodes of hypoproteinemia. The remaining patients were treated successfully with total parenteral nutrition and nutritional counseling.Conclusions Late results presented in this paper agree with the previously published 2-year results of the same patient cohort. Although both procedures are safe and effective, BPD-RYGBP seems to prevail in terms of successful weight loss without a significantly higher incidence of metabolic and non-metabolic complications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The prevalence of iron deficiency one year after RYGB, AGB and SG was estimated to be 20%, 14% and 15%, respectively.
“In representative investigations, the prevalence of iron deficiency one year after RYGB, AGB and SG was estimated to be 20%, 14% and 15%, respectively [51,56,57].”
From Obesity as an emerging risk factor for iron deficiency (2014) · cites this paper as [56]
Cites
Malabsorptive Gastric Bypass in Patients With Superobesity
Brolin, R. E., LaMarca, L. B., Ranatunga, S. A. C. D., Kenler, H. A., Ranatunga, S. A. C. D., Cody, R. P., & Ed.D (2002) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(01)00022-1 · Cited by 385 · see citing works
Kehagias, I., Karamanakos, S. N., Argentou, M., & Kalfarentzos, F. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0479-x · Cited by 349 · see citing works
Self-citationSkroubis, G., Sakellaropoulos, G., Pouggouras, K., Mead, N., Nikiforidis, G., & Kalfarentzos, F. (2002) · Obesity Surgery · doi:10.1381/096089202762252334 · Cited by 303 · see citing works
Self-citationDuodenal Switch: Long-Term Results
Marceau, P., Biron, S., Hould, F., Lebel, S., Marceau, S., Lescelleur, O., Biertho, L. D., & Simard, S. (2007) · Obesity Surgery · doi:10.1007/s11695-008-9435-9 · Cited by 243 · see citing works
Prachand, V. N., DaVee, R. T., & Alverdy, J. C. (2006) · Transactions of the ... Meeting of the American Surgical Association · doi:10.1097/01.sla.0000239086.30518.2a · Cited by 223 · see citing works
Brolin, R. E., & Leung, M. (1999) · Obesity Surgery · doi:10.1381/096089299765553395 · Cited by 214 · see citing works
Buchwald, H. (2002) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(01)01175-9 · Cited by 138 · see citing works
Nelson, D. W., Blair, K. S., & Martin, M. J. (2012) · Archives of Surgery · doi:10.1001/archsurg.2012.1654 · Cited by 128 · see citing works
Buchwald, H. (2002) · Obesity Surgery · doi:10.1381/096089202320995484 · Cited by 125 · see citing works
Inabnet, W. B., Quinn, T. M., Gagner, M., Urban‐Skuro, M., & Pomp, A. (2005) · Obesity Surgery · doi:10.1381/0960892052993468 · Cited by 110 · see citing works
Skroubis, G., Anesidis, S., Kehagias, I., Mead, N., Vagenas, K., & Kalfarentzos, F. E. (2006) · Obesity Surgery · doi:10.1381/096089206776327251 · Cited by 100 · see citing works
Self-citationObesity Surgery Results Depending on Technique Performed: Long-Term Outcome
Gracia, J. A. D., Martínez, M., Elía-Guedea, M., Aguilella, V. M., Dachary, P. R., Jiménez, A., Bielsa, M. A., & del Amo, M. D. A. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9762-x · Cited by 79 · see citing works
Chronaiou, A., Tsoli, M., Kehagias, I., Leotsinidis, M., Kalfarentzos, F. E., & Alexandrides, T. K. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0738-5 · Cited by 78 · see citing works
Self-citationKalfarentzos, F. E., Dimakopoulos, A., Kehagias, I., Loukidi, A., & Mead, N. (1999) · Obesity Surgery · doi:10.1381/096089299765552701 · Cited by 75 · see citing works
Self-citationShort-, Mid- and Long-Term Results of Larrad Biliopancreatic Diversion
Larrad-Jiménez, Á., Sánchez-Cabezudo Díaz-Guerra, C., de Cuadros Borrajo, P., Bretón Lesmes, I., & Moreno Esteban, B. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9035-0 · Cited by 67 · see citing works
Biertho, L. D., Biron, S., Hould, F., Lebel, S., Marceau, S., & Marceau, P. (2010) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2010.03.285 · Cited by 56 · see citing works
Thurnheer, M., Bisang, P., Ernst, B., & Schultes, B. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0708-y · Cited by 54 · see citing works
Effect of bypassing the proximal gut on gut hormones involved with glycemic control and weight loss
Pournaras, D. J., Aasheim, E. T., Bueter, M., Ahmed, A. R., Welbourn, R., Olbers, T., & le Roux, C. W. (2012) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2012.01.021 · Cited by 54 · see citing works
Biliopancreatic diversion for obesity: State of the art
Scopinaro, N., Marinari, G. M., Camerini, G. B., & Papadia, F. S. (2005) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2005.03.216 · Cited by 53 · see citing works
Kalfarentzos, F. E., Skroubis, G., Karamanakos, S. N., Argentou, M., Mead, N., Kehagias, I., & Alexandrides, T. K. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0532-9 · Cited by 50 · see citing works
Self-citationKalfarentzos, F. E., Skroubis, G., Kehagias, I., Mead, N., & Vagenas, K. (2006) · Obesity Surgery · doi:10.1381/096089206775565096 · Cited by 41 · see citing works
Self-citationProspective evaluation of biliopancreatic diversion with Roux-en-Y gastric bypass in the super obese
Kalfarentzos, F. E., Papadoulas, S., Skroubis, G., Kehagias, I., Loukidi, A., & Mead, N. (2004) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2003.11.022 · Cited by 32 · see citing works
Self-citationSkroubis, G., Karamanakos, S. N., Sakellaropoulos, G. C., Panagopoulos, K., & Kalfarentzos, F. E. (2010) · World Journal of Surgery · doi:10.1007/s00268-010-0816-6 · Cited by 28 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Surgery for weight loss in adults
Colquitt, J. L., Pickett, K., Loveman, E., & Frampton, G. K. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003641.pub4 · Cited by 1,567 · see citing works
Obesity as an emerging risk factor for iron deficiency
Aigner, E., Feldman, A., & Datz, C. (2014) · Nutrients · doi:10.3390/nu6093587 · Cited by 328 · see citing works
Long-Term Metabolic Outcomes 5 to 20 Years After Biliopancreatic Diversion
Marceau, P., Biron, S., Marceau, S., Hould, F., Lebel, S., Lescelleur, O., Biertho, L. D., Simard, S., & Kral, J. G. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1599-5 · Cited by 151 · see citing works
Iron deficiency after bariatric surgery: What is the real problem?
Steenackers, N., Van der Schueren, B., Mertens, A., Lannoo, M., Grauwet, T., Augustijns, P., & Matthys, C. (2018) · Proceedings of the Nutrition Society · doi:10.1017/s0029665118000149 · Cited by 106 · see citing works
Sethi, M., Chau, E., Youn, A., Jiang, Y., Fielding, G., & Ren‐Fielding, C. J. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.03.006 · Cited by 102 · see citing works
Rheinwalt, K. P., Plamper, A., Rückbeil, M. V., Kroh, A., Neumann, U. P., & Ulmer, T. F. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04250-3 · Cited by 78 · see citing works
Biliopancreatic Diversion for Severe Obesity: Long-Term Effectiveness and Nutritional Complications
Ballesteros-Pomar, M. D., de Francisco, T. G., Urioste-Fondo, A., González-Herráez, L., Calleja‐Fernández, A., Vidal‐Casariego, A., Fernández, V. S., & Cano‐Rodríguez, I. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1719-2 · Cited by 52 · see citing works
Luca, M. D., Zese, M., Bandini, G., Chiappetta, S., Iossa, A., Merola, G., Piatto, G., Tolone, S., Vitiello, A., Silverii, G. A., et al. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15117 · Cited by 51 · see citing works
Treatment of Severe Protein Malnutrition After Bariatric Surgery
Kuin, C., den Ouden, F., Brandts, H., Deden, L. N., Hazebroek, E. J., van Borren, M. M. G. J., & de Boer, H. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04035-8 · Cited by 41 · see citing works
De Luca, M., Zese, M., Silverii, G. A., Ragghianti, B., Bandini, G., Forestieri, P., Zappa, M. A., Navarra, G., Foschi, D., Musella, M., et al. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06909-4 · Cited by 28 · see citing works
Azagury, D. E., Papasavas, P. K., Hamdallah, I. N., Gagner, M., & Kim, J. J. (2018) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2018.08.001 · Cited by 25 · see citing works
Rolim, F. F. D. A., Santa‐Cruz, F., Campos, J. M., & Ferraz, Á. A. B. (2018) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/0100-6991e-20181916 · Cited by 23 · see citing works
Markers of Bone Metabolism in Obese Individuals Undergoing Laparoscopic Sleeve Gastrectomy
Schollenberger, A. E., Heinze, J. M., Meile, T., Peter, A., Königsrainer, A., & Bischoff, S. C. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1509-2 · Cited by 21 · see citing works
Mantziari, S., Abboretti, F., Favre, L., Thomopoulos, T., Barigou, M., Demartines, N., & Suter, M. (2022) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2022.12.032 · Cited by 20 · see citing works
Metabolic surgery and iron homeostasis
Benotti, P. N., Wood, G. C., Still, C. D., Gerhard, G. S., Rolston, D. D. K., & Bistrian, B. R. (2018) · Obesity Reviews · doi:10.1111/obr.12811 · Cited by 19 · see citing works
Bianchi, A. C., Pomar, A. P., Jiménez-Segovia, M., Martínez-Córcoles, J. A., & González-Argente, X. F. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04777-w · Cited by 20 · see citing works
Metabolic surgery: A paradigm shift in type 2 diabetes management
Pappachan, J. M. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i8.990 · Cited by 18 · see citing works
Luca, M. D., Zese, M., Bandini, G., Zappa, M. A., Bardi, U., Carbonelli, M. G., Carrano, F. M., Casella, G., Chianelli, M., Chiappetta, S., et al. (2024) · Updates in Surgery · doi:10.1007/s13304-024-01996-z · Cited by 16 · see citing works
Change in Mineral Status After Bariatric Surgery: a Meta-analysis
Cao, L. H., Liang, S., Yu, X., Guan, B., Yang, Q., Ming, W., & Chen, Y. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06888-6 · Cited by 15 · see citing works
Bouchard‐Mercier, A., de Toro‐Martín, J., Nadeau, M., Lescelleur, O., Lebel, S., Richard, D., Biertho, L. D., Tchernof, A., & Vohl, M. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03485-6 · Cited by 14 · see citing works
Ongoing Inconsistencies in Weight Loss Reporting Following Bariatric Surgery: a Systematic Review
Mocanu, V., Nasralla, A., Dang, J. T., Jacobson, M., Switzer, N. J., Madsen, K., Birch, D. W., & Karmali, S. (2019) · Obesity Surgery · doi:10.1007/s11695-018-03702-6 · Cited by 14 · see citing works
Comparative effectiveness of metabolic and bariatric surgeries: a network meta-analysis
Malik, A., Malik, M. I., Javaid, S. T., Qureshi, S., & Nadir, A. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01648-7 · Cited by 11 · see citing works
Markopoulos, G., Skroubis, G., Kalfarentzos, F. E., & Kehagias, I. (2021) · Gastroenterology Review · doi:10.5114/pg.2021.108453 · Cited by 9 · see citing works
Self-citationAssessment of Serum Copper State after Gastrectomy with Roux-en-Y Reconstruction for Gastric Cancer
Nakagawa, M., Kojima, K., Inokuchi, M., Kato, K., Sugita, H., Otsuki, S., Higuchi, K., Kobayashi, K., & Sugihara, K. (2015) · Digestive Surgery · doi:10.1159/000431186 · Cited by 7 · see citing works
Gao, Z., Liang, Y., Zheng, C., Wu, Y., Xiang, S., Zhang, X., Li, M., Zhang, Z., & Yang, J. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002942 · Cited by 6 · see citing works
Barazzoni, R., Monami, M., Buscemi, S., Busetto, L., Luca, M. D., Navarra, G., Ragghianti, B., Silverii, G. A., Belluzzi, A., Mannucci, E., et al. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70204 · Cited by 5 · see citing works
Kruschitz, R., Wakolbinger, M., Schindler, K., Prager, G., & Ludvik, B. H. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2645-2 · Cited by 1 · see citing works
Abril, G., & Ángel, S. (2015) · Dialnet (Universidad de la Rioja)
Shetiwy, M., Elghadban, H. M., Negm, M., Basheer, M., & Shoma, A. M. (2018) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2018.55096
Surgery Failure: What Are the Options?
Holihan, J. L., & Wilson, E. B. (2023) · Springer eBooks · doi:10.1007/978-3-031-25828-2_35
Arora, G., Via, M. A., & Mechanick, J. I. (2025) · Springer eBooks · doi:10.1007/978-3-031-77690-8_63-1
Bouchard‐Mercier, A., de Toro‐Martín, J., Nadeau, M., Lescelleur, O., Lebel, S., Richard, D., Biertho, L. D., Tchernof, A., & Vohl, M.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20141107
- Authors
- Skroubis, G., Kouri, N., Mead, N., & Kalfarentzos, F.
- Affiliations
- University of Patras (GR)
- Corresponding author
- Kalfarentzos, Fotis
- Venue
- Obesity Surgery
- Published
- 2013-10-09
- Volume
- 24
- Issue
- 2
- Pages
- 197-204
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2015090917
- Cited by
- 32
- References
- 23
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 3
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Health Sciences › Medicine › Surgery › Body Contouring and Surgery
- Keywords
- Roux-en-Y gastric bypass
- MeSH terms
- Adult, Female, Ferritins, Follow-Up Studies, Humans, Male, Obesity, Morbid, Postoperative Complications, Prospective Studies, Gastric Bypass, Weight Loss, Biliopancreatic Diversion, Body Mass Index, Treatment Outcome, Anemia, Iron-Deficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review