The DOI matches its Crossref record; 210 of the 212 references it cites were found in a registry or an index.
Mechanism Underlying the Weight Loss and Complications of Roux-en-Y Gastric Bypass. Review
Open accessAbstract
Various bariatric surgical procedures are effective at improving health in patients with obesity associated co-morbidities, but the aim of this review is to specifically describe the mechanisms through which Roux-en-Y gastric bypass (RYGB) surgery enables weight loss for obese patients using observations from both human and animal studies. Perhaps most but not all clinicians would agree that the beneficial effects outweigh the harm of RYGB; however, the mechanisms for both the beneficial and deleterious (for example postprandial hypoglycaemia, vitamin deficiency and bone loss) effects are ill understood. The exaggerated release of the satiety gut hormones, such as GLP-1 and PYY, with their central and peripheral effects on food intake has given new insight into the physiological changes that happen after surgery. The initial enthusiasm after the discovery of the role of the gut hormones following RYGB may need to be tempered as the magnitude of the effects of these hormonal responses on weight loss may have been overestimated. The physiological changes after RYGB are unlikely to be due to a single hormone, or single mechanism, but most likely involve complex gut-brain signalling. Understanding the mechanisms involved with the beneficial and deleterious effects of RYGB will speed up the development of effective, cheaper and safer surgical and non-surgical treatments for obesity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“treatment of T2D and obesity with metabolic surgery, which results in increased GLP-1 secretion (98), has been associated with an increased risk of suicide and self-harm (99)”
From The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications (2026) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 201–210 of 210
Flancbaum, L., Verducci, J. S., & Choban, P. S. (1998) · Obesity Surgery · doi:10.1381/096089298765554331 · Cited by 19
Adami, G., Campostano, A., Gandolfo, P., Marinari, G. M., Bessarione, D., & Scopinaro, N. (2008) · European Surgical Research · doi:10.1159/000129469 · Cited by 14
Adami, G., Campostano, A., Bessarione, D., Gandolfo, P., Marinari, G. M., Lamedica, G., & Scopinaro, N. (1993) · Obesity Surgery · doi:10.1381/096089293765559106 · Cited by 13
Taste aversion learning in fyn mutant mice.
Schafe, G. E., Stein, P., Park, C. R., & Bernstein, I. L. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.845 · Cited by 13
Fernando Carrasco, N., Rojas, P., Manuel Ruz, O., Rebolledo, A., Codoceo, J., lnostroza, J., Mizón, C., Papapietro, K., Csendes, A., Flores, J. R., et al. (2008) · Revista médica de Chile · doi:10.4067/s0034-98872008000500004 · Cited by 8
Gastric bypass surgery alters food preferences through changes in the perception of taste
Meillon, S., Miras, A. D., & le Roux, C. W. (2013) · Clinical Practice · doi:10.2217/cpr.13.32 · Cited by 6
Moral challenges with surgical treatment of type 2 diabetes
Hofmann, B., Hjelmesaeth, J. S., & Søvik, T. T. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.07.006 · Cited by 5
Balzano, E., & Naquet, R. (1970) · Physiology & Behavior · doi:10.1016/0031-9384(70)90081-8 · Cited by 4
Pinkney, J. H. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03354.x · Cited by 3
Infl uence of the Intestinal Microbiota on the Critically
Schiffrin, E. J., Marteau, P., & Brassart, D. (2014) · CRC Press eBooks · doi:10.1201/b16442-15 · Cited by 1
Research works printed but not linked: 2
- Sugerman HJ, Londrey GL, Kellum JM, et al. Weight loss with vertical banded gastroplasty and Roux-en-Y gastric bypass: selective vs. random assignment. Am J Surg. 1989;5:457–64.
- Carrasco F, Rojas P, Ruz M, et al. Energy expenditure and body composition in severe and morbid obese women after gastric bypass]. Revista m_Ñdica de Chile. 2008;136:570.
Cited by
Sorted by citations
Genetic identification of vagal sensory neurons that control feeding
Bai, L., Mesgarzadeh, S., Ramesh, K. S., Huey, E. L., Liu, Y., Gray, L. A., Aitken, T. J., Chen, Y., Beutler, L. R., Ahn, J. S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.031 · Cited by 494
Causality of small and large intestinal microbiota in weight regulation and insulin resistance
Scheithauer, T. P. M., Dallinga-Thie, G. M., de Vos, W. M., Nieuwdorp, M., & van Raalte, D. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.002 · Cited by 188
“Interestingly, improvement in glucose metabolism is independent of weight loss, suggesting other mechanisms may be involved [147,148].”
BackgroundObesity: Current and potential pharmacotherapeutics and targets
Narayanaswami, V., & Dwoskin, L. P. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.10.015 · Cited by 188
Hypothalamic detection of macronutrients via multiple gut-brain pathways
Goldstein, N., McKnight, A. D., Carty, J. R. E., Arnold, M., Betley, J. N., & Alhadeff, A. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.018 · Cited by 182
Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status
Ciobârcă, D., Cătoi, A. F., Copăescu, C., Miere, D., & Crișan, G. (2020) · Nutrients · doi:10.3390/nu12010235 · Cited by 194
Metadata
- Authors
- Abdeen, G., & le Roux, C.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Abdeen, G
- ORCID
- Abdeen, G
- Venue
- Obesity Surgery
- Published
- 2015-11-03
- Volume
- 26
- Issue
- 2
- Pages
- 410-421
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- PMC
- PMC4709370
- OpenAlex
- W1900993947
- Cited by
- 162
- References
- 212
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 15 · 2022: 22 · 2021: 23 · 2020: 18 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 9
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Obesity Surgery (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- Roux-en-Y gastric bypass, bariatric surgery
- MeSH terms
- Animals, Eating, Gastrointestinal Hormones, Humans, Obesity, Gastric Bypass, Weight Loss
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
