Cited by 162Bariatric Surgery and OutcomesRegulation of Appetite and ObesityPharmacology and Obesity Treatment

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Mechanism Underlying the Weight Loss and Complications of Roux-en-Y Gastric Bypass. Review

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Abdeen, G, le Roux, CW·2016·Obesity Surgery

DOI 10.1007/s11695-015-1945-7PMC PMC4709370

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Abstract

Various bariatric surgical procedures are effective at improving health in patients with obesity associated co-morbidities, but the aim of this review is to specifically describe the mechanisms through which Roux-en-Y gastric bypass (RYGB) surgery enables weight loss for obese patients using observations from both human and animal studies. Perhaps most but not all clinicians would agree that the beneficial effects outweigh the harm of RYGB; however, the mechanisms for both the beneficial and deleterious (for example postprandial hypoglycaemia, vitamin deficiency and bone loss) effects are ill understood. The exaggerated release of the satiety gut hormones, such as GLP-1 and PYY, with their central and peripheral effects on food intake has given new insight into the physiological changes that happen after surgery. The initial enthusiasm after the discovery of the role of the gut hormones following RYGB may need to be tempered as the magnitude of the effects of these hormonal responses on weight loss may have been overestimated. The physiological changes after RYGB are unlikely to be due to a single hormone, or single mechanism, but most likely involve complex gut-brain signalling. Understanding the mechanisms involved with the beneficial and deleterious effects of RYGB will speed up the development of effective, cheaper and safer surgical and non-surgical treatments for obesity.

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See all 162

Authors: Abdeen, G., & le Roux, C.
Affiliations: Imperial College London (GB)
Corresponding author: Abdeen, G
ORCID: Abdeen, G
Venue: Obesity Surgery
Publisher: Springer Science and Business Media LLC
Published: 2015-11-03
Volume: 26
Issue: 2
Pages: 410-421
ISSN: 0960-8923 (ISSN-L)
1708-0428
DOI: 10.1007/s11695-015-1945-7
PMC: PMC4709370
OpenAlex: W1900993947
Cited by: 162
References: 212
Citations by year: 2026: 8 · 2025: 10 · 2024: 11 · 2023: 15 · 2022: 22 · 2021: 23 · 2020: 18 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 9
FWCI: 2.81
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Obesity Surgery (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Spiral (Imperial College London) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Keywords: Roux-en-Y gastric bypass, bariatric surgery
MeSH terms: Animals, Eating, Gastrointestinal Hormones, Humans, Obesity, Gastric Bypass, Weight Loss

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Mechanism Underlying the Weight Loss and Complications of Roux-en-Y Gastric Bypass. Review

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