Increased Free testosterone levels in men with uncontrolled type 2 diabetes five years after randomization to bariatric surgery
Abstract
Hypogonadism frequently occurs in male patients with type 2 diabetes (T2DM) and is linked to insulin resistance and inflammation. Testosterone levels rise acutely in obese patients following bariatric surgery, though long-term changes have not been investigated in a randomized controlled trial. This study evaluated obese men with T2DM randomized to either bariatric surgery or medical therapy. Testosterone, gonadotropins, body composition, insulin sensitivity, and inflammatory markers were evaluated in 32 patients at baseline and at 5 years. Surgical patients had 47.4% increase in free testosterone compared to medical therapy patients who had 2.2% decrease (P = 0.013). Increase in free testosterone correlated with reduction in body weight, high-sensitivity C-reactive protein (hsCRP), and leptin levels. Prolonged improvements in testosterone levels after bariatric surgery in T2DM are found to be related to reduction in body weight and adipogenic inflammation.
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Reversal of obesity-related low testosterone levels occurs with substantial weight loss after bariatric surgery, with approximately 50% increment in free testosterone concentration.
“Also, reversal of obesity-related low testosterone levels occur with substantial weight loss after bariatric surgery and an approximately 50% increment in free testosterone concentration is seen [75].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [75]
Total and free testosterone concentrations significantly increase after bariatric procedures.
“Total and free testosterone concentrations significantly increase after bariatric procedures [74, 75].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [75]
Cites
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824 · see citing works
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Aminian, A., Brethauer, S. A., Navaneethan, S. D., Singh, R. P., Pothier, C. E., Nissen, S. E., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1600869 · Cited by 2,934 · see citing works
Self-citationBariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Brethauer, S. A., Navaneethan, S. D., Aminian, A., Pothier, C. E., Kim, E. S. H., Nissen, S. E., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401329 · Cited by 1,901 · see citing works
Self-citationDe Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works
Corona, G., Rastrelli, G., Monami, M., Saad, F., Luconi, M., Lucchese, M., Facchiano, E., Sforza, A., Forti, G., Mannucci, E., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0955 · Cited by 414 · see citing works
Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment
Grossmann, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0118 · Cited by 350 · see citing works
Update: Hypogonadotropic Hypogonadism in Type 2 Diabetes and Obesity
Dandona, P., & Dhindsa, S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2724 · Cited by 313 · see citing works
Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa
Frączek, M., & Kurpisz, M. K. (2007) · Journal of Andrology · doi:10.2164/jandrol.106.001149 · Cited by 190 · see citing works
Watanobe, H., & Hayakawa, Y. (2003) · Endocrinology · doi:10.1210/en.2003-0644 · Cited by 169 · see citing works
Taylor, S. R., Meadowcraft, L., & Williamson, B. (2015) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1623 · Cited by 34 · see citing works
Rosenblatt, A., Faintuch, J., & Cecconello, I. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1663-1 · Cited by 21 · see citing works
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Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects
Biobaku, F., Ghanim, H., Monte, S. V., Caruana, J. A., & Dandona, P. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa049 · Cited by 68 · see citing works
Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery
Sultan, S., Patel, A. G., El-Hassani, S., Whitelaw, B., Leca, B. M., Vincent, R. P., le Roux, C. W., Rubino, F., Aywlin, S. J. B., & Dimitriadis, G. K. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00408 · Cited by 39 · see citing works
- Authors
- Pham, N. H., Bena, J., Bhatt, D. L., Kennedy, L., Schauer, P. R., & Kashyap, S. R.
- Affiliations
- Cleveland Clinic Lerner College of Medicine (US)
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- Corresponding author
- Kashyap, Sangeeta R.
- Venue
- Obesity Surgery
- Published
- 2017-11-15
- Volume
- 28
- Issue
- 1
- Pages
- 277-280
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2769225420
- Cited by
- 21
- References
- 11
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ethicon Endo-Surgery (EES IIS 19900)
- American Diabetes Association (1-11-26 CT)
- National Institutes of Health (R01-DK089547)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- free testosterone, type 2 diabetes
- MeSH terms
- Adult, Blood Glucose, Body Composition, C-Reactive Protein, Diabetes Mellitus, Type 2, Follow-Up Studies, Humans, Hypogonadism, Insulin Resistance, Male, Middle Aged, Obesity, Testosterone, Leptin, Bariatric Surgery
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