Serum irisin, adropin, and preptin in obese patients 6 months after bariatric surgery
Open accessAbstract
BACKGROUND/OBJECTIVES: The reduction of body mass after bariatric surgery affects energy metabolism and may involve changes in irisin, preptin, and adropin production. SUBJECTS AND METHODS: were treated with either laparoscopic sleeve gastrectomy(n = 30) or laparoscopic adjustable gastric banding (n = 25). Forty-six (83.6%) were followed-up 6 months after surgery. The control group included 15 healthy non-obese participants. Anthropometric measurements, lipid profiles, HbA1c, and serum irisin, preptin, and adropin were assessed at baseline and on follow-up. RESULTS: The serum concentrations of all three peptides were higher at 6 months than at baseline but only irisin (p = 0.02) and adropin (p = 0.000001) were significantly higher. The increase in preptin was borderline significant (p = 0.051). Changes of serum concentrations of all three peptides were bidirectional. CONCLUSION: Body mass reduction resulting from bariatric procedures may change the production of energy regulating peptides, but not always in a favorable manner.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Weight loss increased levels of adropin in patients who underwent bariatric surgery.
“A study of patients who underwent bariatric surgery showed that weight loss increased levels of adropin [80].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [80]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works
Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J., Matteis, R. D., & Cinti, S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00600.2009 · Cited by 751 · see citing works
Is irisin a human exercise gene?
Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 388 · see citing works
Three new players in energy regulation: Preptin, adropin and irisin
Aydın, S. (2014) · Peptides · doi:10.1016/j.peptides.2014.03.021 · Cited by 258 · see citing works
Xin, C., Liu, J., Zhang, J., Zhu, D., Wang, H., Xiong, L., Lee, Y., Ye, J., Lian, K., Xu, C., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.199 · Cited by 248 · see citing works
Butler, A. A., Tam, C. S., Stanhope, K. L., Wolfe, B. M., Ali, M. R., O'Keeffe, M. M., St‐Onge, M., Ravussin, É., & Havel, P. J. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2194 · Cited by 206 · see citing works
Exercise-induced myokines in health and metabolic diseases
So, B., Kim, H., Kim, J., & Song, W. J. (2014) · Integrative Medicine Research · doi:10.1016/j.imr.2014.09.007 · Cited by 133 · see citing works
Circulating serum irisin levels in obesity and type 2 diabetes mellitus
Shoukry, A., Shalaby, S. M., Bdeer, S. E., Mahmoud, A. A., Mousa, M. M., & Khalifa, A. (2016) · IUBMB Life · doi:10.1002/iub.1511 · Cited by 120 · see citing works
Du, X.-L., Jiang, W.-X., & Lv, Z.-T. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-108730 · Cited by 101 · see citing works
Oelmann, S., Nauck, M., Völzke, H., Bahls, M., & Friedrich, N. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154319 · Cited by 83 · see citing works
Sahin-Efe, A., Upadhyay, J., Ko, B., Dincer, F., Park, K., Migdal, A. L., Vokonas, P., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.10.011 · Cited by 77 · see citing works
Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects
Fukushima, Y., Kurose, S., Shinno, H., Thu, H. C. T., Takao, N., Tsutsumi, H., Hasegawa, T., Nakajima, T., & Kimura, Y. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.5.386 · Cited by 46 · see citing works
Buscemi, S., Corleo, D., Vasto, S., Buscemi, C., Massenti, M. F., Nuzzo, D., Lucisano, G., Barile, A. M., Rosafio, G., Maniaci, V., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.255 · Cited by 46 · see citing works
Fujie, S. J., Hasegawa, N., Kurihara, T., Sanada, K., Hamaoka, T., & Iemitsu, M. (2016) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2016-0310 · Cited by 38 · see citing works
Relationships between preptin and osteocalcin in obese, overweight, and normal weight adults
El-Eshmawy, M. M., & Aal, I. A. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0338 · Cited by 33 · see citing works
New peptides players in metabolic disorders
Mierzwicka, A., & Bolanowski, M. (2016) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.1216271 · Cited by 28 · see citing works
Liu, Y., Lu, Y., Liu, W., Xie, H., Luo, X., Wu, X., Yuan, L., & Liao, E.-Y. (2009) · Amino Acids · doi:10.1007/s00726-009-0281-4 · Cited by 27 · see citing works
Wpływ gastrektomii rękawkowej na poziom irisiny w surowicy pacjentów z chorobliwą otyłością
Demirpençe, M., Yilmaz, H., Çolak, A., Yalçın, H., Toprak, B., Türkön, H., Uğurlu, L., & Aydın, C. (2016) · Endokrynologia Polska · doi:10.5603/ep.a2016.0029 · Cited by 21 · see citing works
The influence of bariatric surgery on serum levels of irisin and nesfatin-1
Majorczyk, M., Staszkiewicz, M., Szklarczyk, J., Major, P., Pisarska, M., Wysocki, M., Stefura, T., Kacprzyk, A., Droś, J., Holda, M. K., et al. (2018) · Acta chirurgica Belgica · doi:10.1080/00015458.2018.1534393 · Cited by 19 · see citing works
Lee, Y. J., Heo, Y., Choi, J., Park, S., Kim, K. K., Shin, D. W., & Kang, J. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16040660 · Cited by 17 · see citing works
Assessment of Serum Vitamin D and Irisin Levels in Obese Patients
Gouda, W., Mageed, L., Shaker, Y., Hamimy, W. I., & Afify, M. (2018) · Clinical Laboratory · doi:10.7754/clin.lab.2018.180416 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Demirpence M, Yilmaz H, Colak A, et al. The effect of sleeve gastrectomy on serum irisin levels in patients with morbid obesity. Endokrynol Pol. 2016;67:481-6.
Cited by
Sorted by citations
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
Adropin’s Role in Energy Homeostasis and Metabolic Disorders
Ali, I. I., D'souza, C., Singh, J., & Adeghate, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158318 · Cited by 84 · see citing works
Frühbeck, G., Fernández-Quintana, B., Paniagua, M., Hernández‐Pardos, A. W., Valentí, V., Moncada, R., Catalán, V., Becerril, S., Gómez‐Ambrosi, J., Portincasa, P., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154261 · Cited by 80 · see citing works
Kolben, Y., Weksler‐Zangen, S., & Ilan, Y. (2020) · Obesity Reviews · doi:10.1111/obr.13108 · Cited by 68 · see citing works
Metabolic adaptations after bariatric surgery: Adipokines, myokines and hepatokines
Faramia, J., Ostinelli, G., Drolet-Labelle, V., Picard, F., & Tchernof, A. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.06.005 · Cited by 44 · see citing works
Özbay, S., Ulupınar, S., Şebin, E., & Altınkaynak, K. (2020) · The Chinese Journal of Physiology · doi:10.4103/cjp.cjp_84_19 · Cited by 32 · see citing works
Exercise in the Cold Causes Greater Irisin Release but May Not Be Enough for Adropin
Ulupınar, S., Özbay, S., Gençoğlu, C., Altınkaynak, K., Şebin, E., & Oymak, B. (2021) · The Chinese Journal of Physiology · doi:10.4103/cjp.cjp_2_21 · Cited by 29 · see citing works
Galectin-1 in Obesity and Type 2 Diabetes
Fryk, E., Silva, V. R. R., & Jansson, P. (2022) · Metabolites · doi:10.3390/metabo12100930 · Cited by 26 · see citing works
Myokines in Appetite Control and Energy Balance
Grannell, A., Kokkinos, A. D., & le Roux, C. W. (2022) · Muscles · doi:10.3390/muscles1010003 · Cited by 23 · see citing works
Jamal, M. H., Abu‐Farha, M., Al‐Khaledi, G., Al‐Sabah, S., Ali, H., Cherian, P., Al‐Khairi, I., AlOtaibi, F., Al-Ali, W., Bosso, M., et al. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.07.022 · Cited by 18 · see citing works
Adropin as an indicator of T2DM and its complications
Zhang, H., & Chen, N. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.06.002 · Cited by 19 · see citing works
Czerwińska, M., Czarzasta, K., & Cudnoch‐Jędrzejewska, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.692642 · Cited by 15 · see citing works
The effect of thyroid dysfunction and treatment on adropin, asprosin and preptin levels in rats
Moğulkoç, R., Dasdelen, D., Baltacı, S. B., Baltacı, A. K., & Sivrikaya, A. (2020) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2020-0058 · Cited by 15 · see citing works
Smith, J. A. H., Soares, R. N., McMillan, N. J., Jurrissen, T. J., Martinez‐Lemus, L. A., Padilla, J., & Manrique‐Acevedo, C. (2022) · Endocrinology · doi:10.1210/endocr/bqac137 · Cited by 13 · see citing works
Role of the Unique Secreted Peptide Adropin in Various Physiological and Disease States
Segherlou, Z. H., Butler, A. A., Candelario‐Jalil, E., & Hoh, B. L. (2024) · Biomolecules · doi:10.3390/biom14121613 · Cited by 12 · see citing works
Hepatokines and their role in cardiohepatic interactions in heart failure
Shouman, W. A., Najmeddine, S., Sinno, L., Nehme, R. D., Ghawi, A. E., Ziade, J. A., Altara, R., Amin, G., Booz, G. W., & Zouein, F. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177356 · Cited by 8 · see citing works
The Impact of Bariatric Surgery on Bone Health: State of the Art and New Recognized Links
Mendonça, F. M., Soares, R. A., Carvalho, D. M., & Freitas, P. (2022) · Hormone and Metabolic Research · doi:10.1055/a-1767-5581 · Cited by 8 · see citing works
Assessment of Serum Vitamin D and Irisin Levels in Obese Patients
Gouda, W., Mageed, L., Shaker, Y., Hamimy, W. I., & Afify, M. (2018) · Clinical Laboratory · doi:10.7754/clin.lab.2018.180416 · Cited by 8 · see citing works
The effect of bariatric surgery on bone Health: From mechanism to management
Ye, Y., Yang, D., & Han, J. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100199 · Cited by 7 · see citing works
Adropin transgenesis improves recognition memory in diet-induced obese LDLR-deficient C57BL/6J mice
Ghoshal, S., Banerjee, S., Zhang, J., Niehoff, M. L., Farr, S. A., & Butler, A. A. (2021) · Peptides · doi:10.1016/j.peptides.2021.170678 · Cited by 7 · see citing works
The Effect of Bariatric Surgery on Irisin Level: a Systematic Review and Meta-analysis
Bidares, M., Safari‐Kish, B., Abedi, M., Malekzadeh‐Shoushtari, H., Jasemnezhad, M., Azarbayejani, N., Aziz, M., Jahromi, S. P., Fouladi, S., & Azizi-Soleiman, F. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06764-3 · Cited by 7 · see citing works
Shantavasinkul, P. C., Omotosho, P. A., Corsino, L., Muehlbauer, M. J., Chattranukulchai, P., & Torquati, A. (2022) · Journal of Laparoendoscopic & Advanced Surgical Techniques · doi:10.1089/lap.2021.0558 · Cited by 5 · see citing works
Association of circulating preptin with non-alcoholic fatty liver disease: A case-control study
Arğun, D., Basım, P., Uysal, B. B., & Argun, F. (2021) · Journal of Surgery and Medicine · doi:10.28982/josam.859388 · Cited by 4 · see citing works
Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis
Jamialahamdi, T., Mirhadi, E., Almahmeed, W. A., Eid, A. H., Al‐Rasadi, K., Nguyen, N. T., Gadde, K. M., & Sahebkar, A. (2024) · Updates in Surgery · doi:10.1007/s13304-024-01866-8 · Cited by 3 · see citing works
Irisan Profile of Obese Women After Moderate Intensity Aerobic Exercise
Firdaus, N. M., Sugiharto, S., & Merawati, D. (2023) · COMPETITOR Jurnal Pendidikan Kepelatihan Olahraga · doi:10.26858/cjpko.v15i2.47729 · Cited by 2 · see citing works
Bariatric Surgery and Metabolic Bone Disease: Crosstalk between Muscle, Adipose Tissue, and Bone
Borges, L. S., Bezerra, A. B. G., Boppre, G., Hatanaka, E., & Fonseca, H. (2026) · Obesity Surgery · doi:10.1007/s11695-026-08488-6 · Cited by 1 · see citing works
Cross-talk between hepatokines as Liver indused-exercise factors and organokinesPreprint
Rad, R. S. (2023) · Research Square · doi:10.21203/rs.3.rs-3734627/v1
Preptin, PPARγ, and NLRP3 as inflammatory biomarkers in pediatric obesity – a pilot study
Kahraman, E. K., Donma, O., Donma, M. M., Yılmaz, A., & Güzel, S. (2025) · BMC Pediatrics · doi:10.1186/s12887-025-06192-5
Kupczyk, W., Boińska, J., Słomka, A., Kupczyk, K., Jackowski, M., & Żekanowska, E. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198932
- Authors
- Glück, M., Glück, J., Wiewióra, M., Rogala, B., & Piecuch, J.
- Affiliations
- Medical University of Silesia (PL)
- Corresponding author
- Glück, M.
- Venue
- Obesity Surgery
- Published
- 2019-06-17
- Volume
- 29
- Issue
- 10
- Pages
- 3334-3341
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W2949719690
- Cited by
- 31
- References
- 22
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 7 · 2018: 1
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Obesity Surgery (publishedVersion, cc-by)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by)
- Funders
- Śląski Uniwersytet Medyczny (KNW-1-195/K/6/K)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- irisin, adropin
- MeSH terms
- Adult, Energy Metabolism, Female, Fibronectins, Humans, Insulin-Like Growth Factor II, Lipids, Male, Middle Aged, Obesity, Morbid, Peptide Fragments, Peptides, Body Mass Index, Case-Control Studies, Intercellular Signaling Peptides and Proteins, Bariatric Surgery, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
