The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Isoprenoids: Remarkable diversity of form and function
Abstract
The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In this review we focus on C‐10 mono‐, C‐15 sesqui‐, and C‐20 diterpenes. Evidence for interconversion between the pathway intermediates farnesyl pyrophosphate and geranylgeranly pyrophosphate and their respective metabolites is examined. The diverse functions of these molecules are discussed in detail, including their ability to regulate expression of the β‐HMG‐CoA reductase and Ras‐related proteins. Additional topics include the mechanisms underlying the apoptotic effects of select isoprenoids, antiulcer activities, and the disposition and degradation of isoprenoids in the environment. Finally, the significance of pharmacological manipulation of the isoprenoid pathway and clinical correlations are discussed.
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Cites
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
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Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
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Cited by
Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?
Kenny, R. G., & Marmion, C. J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00271 · Cited by 636
Terpenes and isoprenoids: a wealth of compounds for global use
Tetali, S. D. (2019) · Planta · doi:10.1007/s00425-018-3056-x · Cited by 422
Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus
Sha, W., Hu, F., Xi, Y., Chu, Y., & Bu, S. (2021) · Journal of Diabetes Research · doi:10.1155/2021/9999612 · Cited by 266
Polyisoprenoids: Structure, biosynthesis and function
SWIEZEWSKA, E., & DANIKIEWICZ, W. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.05.002 · Cited by 196
Perl, A., Hanczko, R., Lai, Z.-W., Oaks, Z., Kelly, R., Borsuk, R., Asara, J. M., & Phillips, P. E. (2015) · Metabolomics · doi:10.1007/s11306-015-0772-0 · Cited by 189
Metadata
- Authors
- Holstein, S. A., & Hohl, R. J.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 39
- Issue
- 4
- Pages
- 293-309
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2003228453
- Cited by
- 249
- References
- 5
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
