Cited by 118Antifungal resistance and susceptibilityFungal and yeast genetics researchMicrobial Natural Products and Biosynthesis

Farnesol Biosynthesis in Candida albicans : Cellular Response to Sterol Inhibition by Zaragozic Acid B

Open access
Hornby, Jacob M., Kebaara, Bessie W., Nickerson, Kenneth W.·2003·Antimicrobial Agents and Chemotherapy

Abstract

The dimorphic fungus Candida albicans produces farnesol as a quorum-sensing molecule that regulates cellular morphology. The biosynthetic origin of farnesol has been resolved by treating these cells with zaragozic acid B, a potent inhibitor of squalene synthase in the sterol biosynthetic pathway. Treatment with zaragozic acid B leads to an eightfold increase in the amount of farnesol produced by C. albicans . Furthermore, C. albicans cell extracts contain enzymatic activity to convert [ 3 H]farnesyl pyrophosphate to [ 3 H]farnesol. Many common antifungal antibiotics (e.g., zaragozic acids, azoles, and allylamines) target steps in sterol biosynthesis. We suggest that the fungicidal activity of zaragozic acid derives in large part from the accumulation of farnesol that accompanies the inhibition of sterol biosynthesis.

Integrity signals

Registry

Crossref · 10.1128/aac.47.7.2366-2369.2003

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Hornby, J. M., Kebaara, B. W., & Nickerson, K. W.
Affiliations
University of Nebraska–Lincoln (US)
Corresponding author
Nickerson, Kenneth W.
Venue
Antimicrobial Agents and Chemotherapy
Published
2003-07
Volume
47
Issue
7
Pages
2366-2369
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2146402972
Cited by
118
References
14
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 5
FWCI
4.27
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Lincoln (University of Nebraska) (submittedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Keywords
Candida albicans, squalene synthase inhibition, sterol biosynthesis, quorum sensing, farnesyl pyrophosphate, antifungal antibiotics, fungicidal activity, dimorphic fungi, fungal cell morphology
MeSH terms
Antifungal Agents, Candida albicans, Farnesol, Sterols, Bridged Bicyclo Compounds, Heterocyclic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review