Consumption of synbiotic bread decreases triacylglycerol and VLDL levels while increasing HDL levels in serum from patients with type-2 diabetes
Abstract
To our knowledge, no reports are available indicating the favorable effects of synbiotic bread consumption on blood lipid profiles among patients with type 2 diabetes mellitus (T2DM). This study was conducted to evaluate the effects of the daily consumption of synbiotic bread on blood lipid profiles of patients with T2DM. This randomized double‐blinded controlled clinical trial was performed with 78 diabetic patients, aged 35–70 years. After a 2‐week run‐in period, subjects were randomly assigned to consume either synbiotic (n = 26), probiotic (n = 26) or control bread (n = 26) for 8 weeks. The synbiotic bread contained viable and heat‐resistant probiotic Lactobacillus sporogenes (1 × 10 8 CFU) and 0.07 g inulin (HPX) as prebiotic per 1 g. The probiotic bread contained L. sporogenes (1 × 10 8 CFU) per 1 g. Patients were asked to consume the synbiotic, probiotic and control breads three times a day in a 40 g package for a total of 120 g/day. Biochemical measurements including blood lipid profiles were conducted before and after 8 weeks of intervention. Consumption of the synbiotic bread, compared to the probiotic and control breads, led to a significant decrease in serum TAG (P = 0.005), VLDL‐C (P = 0.005), TC/HDL‐C (P = 0.002) and a significant increase in serum HDL‐C levels (P = 0.01). No significant effect of synbiotic bread consumption on FPG, TC, LDL‐C and non‐HDL‐C levels was seen compared to the probiotic and control breads (P > 0.05). Trial registry code: http://www.irct.ir IRCT201311215623N13.
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Consumption of symbiotic bread containing Lactobacillus sporogenes for 8 weeks decreased serum triglyceride and VLDL concentrations in type 2 diabetes patients.
“Consumption of symbiotic bread containing the heat-resistant probiotic Lactobacillus sporogenes (1 × 108 CFU/g) for 8 weeks also decreased the serum triglyceride and VLDL concentrations in patients with type 2 diabetes (Shakeri et al., 2014).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Shakeri et al., 2014
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“For instance, our previous study among patients with T2DM did not show any significant difference in lipid profiles following the consumption of a synbiotic food containing L. sporogenes (1 9 107 CFU) and 0.04 g inulin as prebiotic per 1 g after 6 weeks [21].”
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- Authors
- Shakeri, H., Hadaegh, H., Abedi, F., Tajabadi‐Ebrahimi, M., Mazroii, N., Ghandi, Y., & Asemi, Z.
- Affiliations
- Kashan University of Medical Sciences (IR)
- Department of Research and Development of Sahar Bread Company Tehran Islamic Republic of Iran
- Faculty Member of Science Department, Science Faculty Islamic Azad University, Tehran Central Branch Tehran Islamic Republic of Iran
- Corresponding author
- Asemi, Zatollah
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 2014-04-06
- Volume
- 49
- Issue
- 7
- Pages
- 695-701
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2098702370
- Cited by
- 145
- References
- 34
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 16 · 2023: 21 · 2022: 18 · 2021: 7 · 2020: 12 · 2019: 14 · 2018: 9 · 2017: 14 · 2016: 9 · 2015: 5
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- type 2 diabetes, lipid profile, HDL cholesterol, triglycerides, VLDL cholesterol, Bacillus coagulans, inulin, prebiotics, probiotics, dietary intervention
- MeSH terms
- Bread, Diabetes Mellitus, Type 2, Diet, Double-Blind Method, Female, Humans, Lipoproteins, HDL, Lipoproteins, VLDL, Male, Middle Aged, Triglycerides, Synbiotics
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