The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n‐6 or n‐3 fatty acids
Abstract
This study evaluated the effects of conjugated linoleic acids (CLA) on tissue fatty acid composition and ex vivo prostaglandin E 2 (PGE 2) production in rats given diets varying in n‐6 and n‐3 fatty acids. Four groups of rats were given a basal semipurified diet (AIN‐93G) containing 70 g/kg of added fat for 42 d. The fat treatments were formulated to contain CLA (0 vs. 10 g/kg of diet) and n‐6 (soybean oil having an n‐6/n‐3 ratio of 7.3) and n‐3 fatty acids (menhaden oil+safflower oil having an n‐6/n‐3 ratio of 1.8) in different ratios in a 2×2 factorial design. Fatty acids in liver, serum, muscle, heart, brain, spleen, and bone (cortical, marrow, and periosteum) were analyzed by capillary gas‐liquid chromatography. The various dietary lipid treatments did not affect growth; however, CLA improved feed efficiency. The CLA isomers were found in all rat tissues analyzed although their concentrations varied. Dietary CLA decreased the concentrations of 16∶1n−7, 18∶1, total monounsaturates and n−6 fatty acids, but increased the concentrations of n−3 fatty acids (22∶5n−3 and 22∶6n−3), and saturates in the tissues analyzed. Ex vivo PGE 2 production in bone organ culture was decreased by n−3 fatty acids and CLA. We speculate that CLA reduced the concentration of 18∶1 fatty acids by inhibiting liver Δ9‐desaturase activity. The fact that CLA lowered ex vivo PGE 2 production in bone organ culture suggests that these conjugated fatty acids have the potential to influence bone formation and resorption.
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Cites
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Conjugated linoleic acid and atherosclerosis in rabbits
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Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid
Ha, Y. L., Grimm, N. K., & Pariza, M. W. (1987) · Carcinogenesis · doi:10.1093/carcin/8.12.1881 · Cited by 925
Mammary cancer prevention by conjugated dienoic derivative of linoleic acid.
Ip, C., Chin, S. F., Scimeca, J. A., & Pariza, M. W. (1991) · PubMed · Cited by 743
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Conjugated linoleic acid modulates hepatic lipid composition in mice
Belury, M. A., & Kempa‐Steczko, A. (1997) · Lipids · doi:10.1007/s11745-997-0025-0 · Cited by 367
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Cited by
Implication of Conjugated Linoleic Acid (CLA) in Human Health
Dilzer, A., & Park, Y. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.501409 · Cited by 375
Conjugated linoleic acid supplementation in humans—metabolic effects
Smedman, A., & Vessby, B. (2001) · Lipids · doi:10.1007/s11745-001-0784-7 · Cited by 305
Atherogenic High-Fat Diet Reduces Bone Mineralization in Mice
Parhami, F., Tintut, Y., Beamer, W. G., Gharavi, N., Goodman, W., & Demer, L. L. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.1.182 · Cited by 302
Parhami, F., Jackson, S. M., Tintut, Y., Le, V., Balucan, J. P., Territo, M., & Demer, L. L. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.12.2067 · Cited by 259
The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers
Nugent, A. P., Roche, H. M., Noone, E. J., Long, A., Kelleher, D. K., & Gibney, M. J. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602132 · Cited by 71
Metadata
- Authors
- Li, Y., & Watkins, B. A.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1998-04
- Volume
- 33
- Issue
- 4
- Pages
- 417-425
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2091706696
- Cited by
- 261
- References
- 19
- FWCI
- 21.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n‐6 or n‐3 fatty acids. https://app.cochat.ai/papers/10.1007/s11745-998-0223-9
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- Li, Y., & Watkins, B. A. (1998). Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n‐6 or n‐3 fatty acids. Lipids. https://doi.org/10.1007/s11745-998-0223-9
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