The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study
Open accessAbstract
PurposeThis study aimed to determine the prevalence of sarcopenia and examine whether sarcopenia was associated with overall and breast-cancer-specific mortality in a cohort of women diagnosed with breast cancer (stages I–IIIA).MethodsA total of 471 breast cancer patients from western Washington State and New Mexico who participated in the prospective Health, Eating, Activity, and Lifestyle Study were included in this study. Appendicular lean mass was measured using dual X-ray absorptiometry scans at study inception, on average, 12 months after diagnosis. Sarcopenia was defined as two standard deviations below the young healthy adult female mean of appendicular lean mass divided by height squared (<5.45 kg/m2). Total and breast-cancer-specific mortality data were obtained from Surveillance Epidemiology and End Results registries. Multivariable Cox proportional hazard models assessed the associations between sarcopenia and mortality.ResultsMedian follow-up was 9.2 years; 75 women were classified as sarcopenic, and among 92 deaths, 46 were attributed to breast cancer. In multivariable models that included age, race-ethnicity/study site, treatment type, comorbidities, waist circumference, and total body fat percentage, sarcopenia was independently associated with overall mortality (hazard ratio (HR) = 2.86; 95 % CI, 1.67–4.89). Sarcopenic women had increased risk of breast-cancer-specific mortality, although the association was not statistically significant (HR = 1.95, 95 % CI, 0.87–4.35).ConclusionSarcopenia is associated with an increased risk of overall mortality in breast cancer survivors and may be associated with breast-cancer-specific mortality. The development of effective interventions to maintain and/or increase skeletal muscle mass to improve prognosis in breast cancer survivors warrants further study.Implications for Cancer SurvivorsSuch interventions may help breast cancer patients live longer.
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Epidemiology of Sarcopenia among the Elderly in New Mexico
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Self-citationFielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
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“Fat and lean soft tissue measurements We used DXA to quantify whole- and regional-body composition, at baseline (New Mexico site: Lunar model DPX; Lunar Radiation Corporation, Madison, WI, USA; Washington site: Hologic QDR 1500, Hologic, Inc., Bedford, MA, USA).”
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Cited by
Caan, B. J., Cespedes Feliciano, E. M., Prado, C. M., Alexeeff, S., Kroenke, C. H., Bradshaw, P., Quesenberry, C. P., Weltzien, E. K., Castillo, A. L., Olobatuyi, T. A., et al. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.0137 · Cited by 565
Ryan, A. M., Power, D. G., Daly, L., Cushen, S. J., Ní Bhuachalla, Ē., & Prado, C. M. (2016) · Proceedings of the Nutrition Society · doi:10.1017/s002966511500419x · Cited by 542
Batsis, J. A., Mackenzie, T. A., Barre, L. K., Lopez-Jimenez, F., & Bartels, S. J. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.117 · Cited by 479
Playdon, M. C., Bracken, M. B., Sanft, T. B., Ligibel, J. A., Harrigan, M., & Irwin, M. L. (2015) · Journal of the National Cancer Institute · doi:10.1093/jnci/djv275 · Cited by 309
Buffart, L. M., Galvão, D. A., Brug, J., Chinapaw, M. J. M., & Newton, R. U. (2014) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.06.007 · Cited by 266
Metadata
- Authors
- Villaseñor, A., Ballard-Barbash, R., Baumgartner, K., Baumgartner, R., Bernstein, L., McTiernan, A., & Neuhouser, M. L.
- Venue
- Journal of Cancer Survivorship
- Published
- 2012-10-04
- Volume
- 6
- Issue
- 4
- Pages
- 398-406
- ISSN
- 1932-2259 (ISSN-L)
- 1932-2267
- OpenAlex
- W2074514491
- Cited by
- 274
- References
- 52
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- green
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