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Cited by 9Childhood Cancer Survivors' Quality of LifeCancer survivorship and careEconomic and Financial Impacts of Cancer

Positive and negative survivor-specific psychosocial consequences of childhood cancer: the DCCSS-LATER 2 psycho-oncology study

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Maas, Anne, Maurice-Stam, Heleen, van der Aa-van Delden, Alied M., van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H. +13 more·2024·Journal of Cancer Survivorship
DOI 10.1007/s11764-023-01394-1PMC PMC11424676
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Abstract

Purpose: Numerous studies investigated generic psychosocial outcomes in survivors of childhood cancer (CCS). The present study aimed to describe survivor-specific psychosocial consequences in CCS, and to identify socio-demographic and medical associated factors. Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963–2001) part 2 (age ≥ 18 years, diagnosed < 18 years, ≥ 5 years since diagnosis) completed the Benefit & Burden Scale (BBSC) and the Impact of Cancer–Childhood Cancer (IOC-CS). Items were scored on a 5-point Likert scale (range 1–5). We examined outcomes with descriptive statistics, and socio-demographic and medical associated factors with regression analyses, corrected for multiple testing (p < 0.004). Results: CCS, N = 1713, age mean (M) 36 years, 49% female, ≥ 15 years since diagnosis, participated. On average, CCS reported ‘somewhat’ Benefit (M = 2.9), and ‘not at all’ to ‘a little’ Burden (M = 1.5) of childhood cancer. Average scores on IOC-CS’ positive impact scales ranged from 2.5 (Personal Growth) to 4.1 (Socializing), and on the negative impact scales from 1.4 (Financial Problems) to 2.4 (Thinking/Memory). Apart from cognitive problems, CCS reported challenges as worries about relationship status, fertility, and how cancer had affected siblings. Female sex was associated with more Personal Growth, and more negative impact. CCS more highly educated, partnered, and employed had higher positive and lower negative impact. CCS older at diagnosis reported more positive impact. CNS tumor survivors and those who had head/cranium radiotherapy had higher negative impact. CNS tumor survivors reported less positive impact. Conclusion and implications: The majority of CCS reported positive impact of cancer while most CCS reported little negative impact. While this may indicate resiliency in most CCS, health care providers should be aware that they can also experience survivor-specific challenges that warrant monitoring/screening, information provision and psychosocial support.

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  • The analyses adjusted for attained age, sex, number of health conditions, and time since diagnosis to mitigate potential confounding.

    “Associations were assessed with regression analysis, adjusting for attained age, sex, number of health conditions, and time since diagnosis, while correcting for multiple testing ( p &lt; 0.004).”

    From Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study (2024) · cites this paper as [29]

    The Methods (Statistical analysis; page not provided) confirm multiple linear regression and a 0.004 significance threshold to correct for multiple testing. Methods (Measures; page not provided) lists attained age, sex, and time since diagnosis as collected characteristics, but the available passages do not establish that all three were adjustment variables; they do not identify number of health conditions as a variable. (LLM, conf=0.85)

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Authors
Maas, A., Maurice-Stam, H., van der Aa-van Delden, A. M., van Dalen, E. C., van Dulmen-den Broeder, E., Tissing, W. J. E., Loonen, J. J., van der Pal, H. J. H., de Vries, A. C. H., van den Heuvel-Eibrink, M. M., Janssens, G. O., Ronckers, C., Neggers, S., Bresters, D., Louwerens, M., Versluys, B. A. B., van der Heiden-van der Loo, M., Kremer, L. C. M., van Gorp, M., Grootenhuis, M. A., & on behalf of the Dutch LATER study group
Affiliations
  • Princess Máxima Center (NL)
  • University Medical Center Groningen (NL)
  • Radboud University Medical Center (NL)
  • University Medical Center Utrecht (NL)
  • Johannes Gutenberg University Mainz (DE)
  • Erasmus MC (NL)
  • Leiden University Medical Center (NL)
Corresponding author
Maas, Anne
ORCID
Venue
Journal of Cancer Survivorship
Publisher
Springer Science and Business Media LLC
Published
2023-05-11
Volume
18
Issue
5
Pages
1505-1516
ISSN
  • 1932-2259 (ISSN-L)
  • 1932-2267
DOI
10.1007/s11764-023-01394-1
PMC
PMC11424676
OpenAlex
W4376225449
Cited by
9
References
6
Citations by year
2026: 2 · 2025: 3 · 2024: 4
FWCI
3.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Cancer Survivorship (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, cc-by)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
  • Leiden Repository (Leiden University) (submittedVersion, cc-by)
  • PUBLISSO (German National Library of Medicine) (submittedVersion, cc-by)
  • Radboud Repository (Radboud University) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
Funders
Stichting Kinderen Kankervrij (361 & 171)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Financial Impacts of Cancer
Keywords
childhood cancer survivors, psychosocial consequences, cognitive complaints, central nervous system tumors, cranial irradiation, fertility concerns, relationship status, siblings, resilience, sociodemographic factors
MeSH terms
Cancer Survivors, Psycho-Oncology, Adolescent, Adult, Child, Child, Preschool, Female, Humans, Male, Middle Aged, Neoplasms, Quality of Life, Surveys and Questionnaires, Cohort Studies, Young Adult

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