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Cited by 7Childhood Cancer Survivors' Quality of LifeCancer survivorship and careMultiple and Secondary Primary Cancers

The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer: results of the DCCSS-LATER study

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Maas, Anne, Maurice-Stam, Heleen, Feijen, Lieke E.A.M., Teepen, Jop C., van der Aa-van Delden, Alied M., Streefkerk, Nina, van Dulmen-den Broeder, Eline, Tissing, Wim J. E. +13 more·2025·Journal of Cancer Survivorship
DOI 10.1007/s11764-024-01617-zPMC PMC12546303
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Abstract

PURPOSE: Investigate the association between presence, number and type of clinically relevant health conditions and a range of psychosocial outcomes (emotional, social, cognitive, physical) in survivors of childhood cancer (CCS). METHODS: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963-2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013-2014), and questionnaires on psychosocial outcomes (2017-2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004). RESULTS: A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large. CONCLUSION AND IMPLICATIONS: Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.

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  • The analyses adjusted for attained age, sex, number of health conditions, and time since diagnosis to mitigate potential confounding.

    “Associations were assessed with regression analysis, adjusting for attained age, sex, number of health conditions, and time since diagnosis, while correcting for multiple testing ( p &lt; 0.004).”

    From Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study (2024) · cites this paper as [9]

    The Statistical analysis section says the regression analyses adjusted for attained age, sex, and time since diagnosis, and used a significance threshold of 0.004 to correct for multiple testing. The Results section describes number of health conditions as a variable whose association with psychosocial outcomes was assessed, not as an adjustment variable. (LLM, conf=0.91)

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  • Specific health conditions were associated with psychosocial problems in childhood cancer survivors.

    “Additionally, we found that specific health conditions were associated with psychosocial problems [9].”

    From Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study (2024) · cites this paper as [9]

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Authors
Maas, A., Maurice-Stam, H., Feijen, L. E. A. M., Teepen, J. C., van der Aa-van Delden, A. M., Streefkerk, N., van Dulmen-den Broeder, E., Tissing, W. J. E., Loonen, J. J., van der Pal, H. J. H., de Vries, A. C. H., van den Heuvel-Eibrink, M. M., Ronckers, C., Neggers, S., Bresters, D., Louwerens, M., Versluys, B. A. B., van der Heiden-van der Loo, M., Kremer, L. C. M., Grootenhuis, M., & the Dutch LATER study group
Affiliations
  • Princess Máxima Center (NL)
  • University Medical Center Groningen (NL)
  • Radboud University Medical Center (NL)
  • Johannes Gutenberg University Mainz (DE)
  • Erasmus MC (NL)
  • Leiden University Medical Center (NL)
  • University Medical Center Utrecht (NL)
Corresponding author
Maas, Anne
ORCID
Venue
Journal of Cancer Survivorship
Publisher
Springer Science and Business Media LLC
Published
2024-06-22
Volume
19
Issue
6
Pages
2066-2076
ISSN
  • 1932-2259 (ISSN-L)
  • 1932-2267
DOI
10.1007/s11764-024-01617-z
PMC
PMC12546303
OpenAlex
W4399917083
Cited by
7
References
9
Citations by year
2026: 3 · 2025: 3 · 2024: 1
FWCI
4.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Cancer Survivorship (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, cc-by)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
  • Leiden Repository (Leiden University) (submittedVersion, cc-by)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
Funders
Stichting Kinderen Kankervrij (361)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Epidemiology › Multiple and Secondary Primary Cancers
Keywords
childhood cancer survivors, psychosocial outcomes, comorbid health conditions, secondary malignancies, gastrointestinal diseases, endocrine conditions, anxiety, depression, health-related quality of life, post-traumatic stress disorder, emotional functioning, social functioning, physical function
MeSH terms
Cancer Survivors, Adolescent, Adult, Child, Female, Humans, Male, Middle Aged, Neoplasms, Netherlands, Quality of Life, Surveys and Questionnaires, Young Adult

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