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Cited by 133Childhood Cancer Survivors' Quality of LifeCancer survivorship and careFamily Support in Illness

Psychological Outcomes, Health-Related Quality of Life, and Neurocognitive Functioning in Survivors of Childhood Cancer and Their Parents

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Michel, Gisela, Brinkman, Tara M., Wakefield, Claire E., Grootenhuis, Martha·2020·Pediatric Clinics of North America
DOI 10.1016/j.pcl.2020.07.005
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Abstract

Childhood cancer disrupts the lives of patients and their families and affects acute and long-term psychological health. This article summarizes (1) psychological challenges, including depression, anxiety, worries, and posttraumatic stress, as well as positive outcomes such as benefit finding and posttraumatic growth in young survivors and parents; (2) health-related quality of life; (3) interventions to support survivors and parents with psychological difficulties; and (4) neurocognitive problems and interventions to help alleviate them. Although many survivors and parents fare well in the long term, many survivors may benefit from interventions. Interventions should be further evaluated and integrated into routine clinical care.

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Crossref · 10.1016/j.pcl.2020.07.005

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  • With the exception of the eSCCIP, most interventions are implemented face-to-face, limiting benefits to rural-remote families.

    “With the exception of the eSCCIP [23], most interventions are also implemented face-to-face, limiting benefits to rural-remote families [7,25,27,33].”

    From Providing psychological support to parents of childhood cancer survivors: ‘cascade’ intervention trial results and lessons for the future (2021) · cites this paper as [7]

    In “Survivors of Childhood Cancer and Their Parents” (page unavailable), the review describes several interventions delivered online, by telephone, or through videoconferencing—not just eSCCIP. Although it also describes face-to-face programs, its account runs contrary to the claim that most interventions are face-to-face apart from eSCCIP. The cited passages do not establish that delivery format limits benefits to rural-remote families. (LLM, conf=0.85)

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  • Childhood cancer survivors with certain socio-demographic characteristics (female sex, lower educational attainment, unemployment) and cancer-related medical characteristics (CNS tumor diagnosis) reported poorer psychosocial outcomes.

    “In line with other studies, we found that CCS with certain socio-demographic characteristics, including female sex, lower educational attainment, and unemployment, along with cancer-related medical characteristics, such as a CNS tumor diagnosis, reported poorer psychosocial outcomes [4, 8].”

    From Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study (2024) · cites this paper as [4]

    The Psychological Health in Survivors section identifies women and CNS tumor survivors as at higher risk for psychological distress; the Health-Related Quality of Life section also identifies socioeconomic disadvantage as a risk factor. The paper does not specifically identify lower educational attainment or unemployment as predictors of poorer psychosocial outcomes. Its Neurocognitive Problems section instead describes reduced college graduation and employment as outcomes associated with neurocognitive deficits. (LLM, conf=0.86)

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  • Parents/caregivers of childhood cancer survivors can experience poor quality of life, anxiety, depression, loneliness, and fear of their child's cancer recurring.

    “Despite the benefits of cancer treatment, this can be a vulnerable time for parents/caregivers, who can experience poor quality of life (QOL),_ENREF_9 anxiety, depression, loneliness _ENREF_8 [3,4,5,6,7], and fear of their child’s cancer recurring [4,5].”

    From Providing psychological support to parents of childhood cancer survivors: ‘cascade’ intervention trial results and lessons for the future (2021) · cites this paper as [7]

    The section “Psychological Outcomes in Parents of Childhood Cancer Survivors” says some parents report high anxiety and worry about relapse; the review table also notes that depressive symptoms may persist in some parents. The passages do not establish poor quality of life or loneliness specifically among parents or caregivers. Page numbers are not available in our copy. (LLM, conf=0.85)

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  • Certain subgroups of childhood cancer survivors report worse health-related quality of life compared to general population norms and experience symptoms like anxiety, depression, and posttraumatic stress.

    “However, certain subgroups report worse HRQOL compared to general population norms, and experience symptoms like anxiety, depression, and posttraumatic stress [4, 5].”

    From Risk and Protective Factors of Psychosocial Functioning in Survivors of Childhood Cancer: Results of the DCCSS-LATER Study (2024) · cites this paper as [4]

  • Many interventions have not been evaluated with rigorous research designs in pediatric oncology.

    “However, few interventions have implemented evidence-based treatments [31,32] and many have not been evaluated with rigorous research designs in pediatric oncology [7,24,25,27].”

    From Providing psychological support to parents of childhood cancer survivors: ‘cascade’ intervention trial results and lessons for the future (2021) · cites this paper as [7]

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Research works printed but not linked: 1

  1. Schwartz CE, Feinberg RG, Jilinskaia E, et al. An evaluation of a psychosocial intervention for survivors of childhood cancer: paradoxical effects of response shift over time. Psychooncology 1999;8(4):344-54.

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Authors
Michel, G., Brinkman, T. M., Wakefield, C. E., & Grootenhuis, M.
Affiliations
  • University of Lucerne (CH)
  • St. Jude Children's Research Hospital (US)
  • UNSW Sydney (AU)
  • Princess Máxima Center (NL)
Corresponding author
Michel, Gisela
ORCID
Venue
Pediatric Clinics of North America
Publisher
Elsevier BV
Published
2020-12
Volume
67
Issue
6
Pages
1103-1134
ISSN
0031-3955 (ISSN-L)
DOI
10.1016/j.pcl.2020.07.005
OpenAlex
W3089288901
Cited by
133
References
89
Citations by year
2026: 28 · 2025: 25 · 2024: 36 · 2023: 22 · 2022: 13 · 2021: 8 · 2020: 1
FWCI
2.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Pediatric Clinics of North America (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Sociology and Political Science › Family Support in Illness
Keywords
childhood cancer survivors, parental caregivers, psychological outcomes, health-related quality of life, neurocognitive function, depression, anxiety, post-traumatic stress, benefit finding, posttraumatic growth, psychological intervention, neurocognitive interventions
MeSH terms
Cancer Survivors, Adaptation, Psychological, Humans, Mental Health, Parents, Quality of Life, Stress, Psychological

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