Dangerous Allergens: Why Some Allergens are Bad Actors
Open accessAbstract
Immune responses can be compartmentalized into innate versus adaptive components. This relatively recent dichotomy positioned the innate immune system at the interface between the host and the external environment and provided a new conceptual framework with which to view allergic diseases, including asthma. Airway epithelial cells and dendritic cells are key components of the innate immune system in the nose and lung and are now known to be intimately involved in allergen recognition and in modulating allergic immune responses. Here we review current thinking about how these two key cell types sense and respond to inhaled allergens, and emphasize how an understanding of "allergic innate immunity" can translate into new thinking about mechanisms of allergen sensitization and potentially lead to new therapeutic targets.
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Proteolytic allergens directly disrupt the apical junctional complex via proteolysis, leading to barrier dysfunction.
“Proteolytic allergens directly disrupt the apical junctional complex via proteolysis, leading to barrier dysfunction.430”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [430]
The section on allergen recognition reports that the dust-mite allergen Der p disrupts airway epithelial tight junctions in a protease-dependent manner; the References annotation for study 29 says an allergen protease increased bronchial epithelial permeability. This supports the proposed barrier effect, but the copy does not establish that proteolytic allergens generally disrupt the entire apical junctional complex. (LLM, conf=0.83)
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- Authors
- Georas, S. N., Rezaee, F., Lerner, L., & Beck, L.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Georas, Steve N.
- Venue
- Current Allergy and Asthma Reports
- Published
- 2010-03
- Volume
- 10
- Issue
- 2
- Pages
- 92-98
- ISSN
- 1529-7322 (ISSN-L)
- 1534-6315
- PMC
- PMC2862603
- OpenAlex
- W1974753554
- Cited by
- 16
- References
- 57
- Citations by year
- 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2012: 3
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Allergy and Asthma Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL071933)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- aeroallergens, airway epithelial cells, dendritic cells, allergen identification, allergen sensitization, asthma, allergic inflammation, therapeutic target
- MeSH terms
- Allergens, Inhalation, Asthma, Dendritic Cells, Humans, Immunity, Innate, Immunologic Factors, Lung, Nose, Respiratory Mucosa
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