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Cited by 181Gut microbiota and healthDermatology and Skin DiseasesFood Allergy and Anaphylaxis Research

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Birth Mode, Breastfeeding, Pet Exposure, and Antibiotic Use: Associations With the Gut Microbiome and Sensitization in Children

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Kim, Haejin, Sitarik, Alexandra R., Woodcroft, Kimberley, Johnson, Christine Cole, Zoratti, Edward·2019·Current Allergy and Asthma Reports
DOI 10.1007/s11882-019-0851-9PMC PMC7376540
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Abstract

Purpose of review The infant gut microbiota has become a focus of multiple epidemiologic and cohort studies. This microbiome is derived from the mother (via the vaginal canal, maternal skin contact, breastfeeding, and possibly in utero microbial transfer) and is likely influenced by multiple external factors. It is now believed by some experts that colonization and formation of the newborn and alterations of gut microbiota in children are dependent on earlier alterations of the microbiota of mothers during or perhaps even before pregnancy. This review will focus on specific factors (pet keeping, breastfeeding, antibiotic use, and mode of delivery) that influence the infant gut microbiome and atopy. Recent findings This is a review of recent literature describing how pet keeping, breastfeeding, antibiotic use, and mode of delivery influences and changes the infant gut microbiome and atopy. General trends in gut microbiota differences have emerged in different birth cohorts when each external factor is analyzed, but consistency between studies is difficult to replicate. The aforementioned factors do not seem to confer an overwhelming risk for development of atopy alone. This review provides a comprehensive review of early life environmental factors and their influence on the infant gut microbiome and atopy.

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  • Children treated with antibiotics, specially macrolides, amoxicillin, cefdinir, vancomycin, and tetracyclines, had a higher incidence of obesity, since antibiotics can alter the composition of the intestinal microbiota, leading to a dysbiotic state.

    “Children treated with antibiotics, specially macrolides, amoxicillin, cefdinir, vancomycin, and tetracyclines (69) had a higher incidence of obesity (3), since antibiotics can alter the composition of the intestinal microbiota, leading to a dysbiotic state (3, 70).”

    From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [70]

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Metadata

Authors
Kim, H., Sitarik, A. R., Woodcroft, K., Johnson, C. C., & Zoratti, E.
Affiliations
Henry Ford Health (US)
ORCID
Venue
Current Allergy and Asthma Reports
Publisher
Springer Science and Business Media LLC
Published
2019-03-11
Volume
19
Issue
4
Pages
22-22
ISSN
  • 1529-7322 (ISSN-L)
  • 1534-6315
DOI
10.1007/s11882-019-0851-9
PMC
PMC7376540
OpenAlex
W2921908174
Cited by
181
References
3
Citations by year
2026: 11 · 2025: 21 · 2024: 25 · 2023: 32 · 2022: 41 · 2021: 34 · 2020: 12 · 2019: 5
FWCI
2.03
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Allergy and Asthma Reports (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (to come)
  • National Institute of Allergy and Infectious Diseases (to come)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
Keywords
infant gut microbiota, atopy, pet exposure, breastfeeding, antibiotic use, mode of delivery, maternal microbiota, sensitization
MeSH terms
Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Breast Feeding, Child, Female, Humans, Infant, Infant, Newborn, Pregnancy, Prenatal Exposure Delayed Effects, Delivery, Obstetric, Pets

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