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Cited by 282Asthma and respiratory diseasesAllergic Rhinitis and SensitizationOccupational exposure and asthma

Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy

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Remes, Sami T., Castro-Rodriguez, Jose A., Holberg, Catharine J., Martinez, Fernando D., Wright, Anne L.·2001·Journal of Allergy and Clinical Immunology
DOI 10.1067/mai.2001.117797
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Abstract

Background Influence of household pets in the development of childhood asthma or atopy has been controversial. Objective The purpose of this study was to investigate whether pet exposure in early life decreases the subsequent risk of frequent wheezing and/or allergic sensitization. Methods This was a prospective observational birth cohort study. The setting was a large health maintenance organization in Tucson, Ariz; the subjects were a population sample of 1246 newborns enrolled at birth and followed prospectively to age 13 years. The main outcome measures were as follows: time to first report of frequent wheezing (>3 episodes in the past year), skin prick test reactivity at 6 years and 11 years of age, and total serum IgE at 9 months, 6 years, and 11 years of age. Results Children living in households with > or =1 indoor dogs at birth were less likely to develop frequent wheeze than those not having indoor dogs (P =.004). This inverse association was confined to children without parental asthma (hazard ratio = 0.47; P <.001 [Cox regression]) and was not evident for children with parental asthma (hazard ratio = 0.96; P =.87). Adjustment by potential confounders did not change the results. Indoor cat exposure was not significantly associated with the risk of frequent wheezing. Neither cat exposure in early life nor dog exposure in early life was associated with skin prick test reactivity or total serum IgE at any age. Conclusion Dog exposure in early life might prevent the development of asthma-like symptoms, at least in low-risk children with no family history of asthma. Nevertheless, early pet exposure does not seem to significantly influence the development of allergic sensitization.

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  • The potential protective effects of early-life pet exposure against asthma-like symptoms appear to be closely linked to family (especially maternal) history of asthma.

    “Additionally, the potential protective effects of early-life pet exposure against asthma-like symptoms appear to be closely linked to family (especially maternal) history of asthma [165,166].”

    From Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control (2025) · cites this paper as [165]

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Authors
Remes, S. T., Castro-Rodriguez, J. A., Holberg, C. J., Martinez, F. D., & Wright, A. L.
Affiliations
University of Arizona (US)
ORCID
Remes, Sami T.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2001-10
Volume
108
Issue
4
Pages
509-515
ISSN
0091-6749 (ISSN-L)
DOI
10.1067/mai.2001.117797
OpenAlex
W2011659244
Cited by
282
References
29
Citations by year
2026: 1 · 2025: 6 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 7 · 2015: 10 · 2014: 7 · 2013: 6 · 2012: 9
FWCI
17.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Suomen Lääketieteen Säätiö
  • National Institutes of Health (5p50hl014136-25)
  • National Heart, Lung, and Blood Institute (HL-14136, R01HL056177, HL-56177)
Topics
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
dog exposure, household pets, childhood asthma, atopy, allergen sensitization, serum IgE, skin prick test reactivity, indoor cats, parental asthma, early life exposure, birth cohort
MeSH terms
Adolescent, Animals, Animals, Domestic, Arizona, Asthma, Cats, Child, Child, Preschool, Dogs, Environment, Controlled, Environmental Exposure, Female, Humans, Hypersensitivity, Immunoglobulin E, Male, Prospective Studies, Respiratory Hypersensitivity, Respiratory Sounds, Environmental Illness

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