Mediterranean diet and cardiovascular disease: historical perspective and latest evidence

de Lorgeril, Michel

doi:10.1007/s11883-013-0370-4

Cited by 60Nutritional Studies and DietCardiovascular Health and Risk FactorsFatty Acid Research and Health

Mediterranean diet and cardiovascular disease: historical perspective and latest evidence

de Lorgeril, Michel·2013·Current Atherosclerosis Reports

DOI 10.1007/s11883-013-0370-4

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Abstract

The concept that the Mediterranean diet was associated with a lower incidence of cardiovascular disease (CVD) was first proposed in the 1950s. Since then, there have been randomized controlled trials and large epidemiological studies that reported associations with lower CVD: in 1994 and 1999, the reports of the intermediate and final analyses of the trial Lyon Diet Heart Study; in 2003, a major epidemiological study in Greece showing a strong inverse association between a Mediterranean score and the risk of cardiovascular complications; in 2011-2012, several reports showing that even non-Mediterranean populations can gain benefits from long-term adhesion to the Mediterranean diet; and in 2013, the PREDIMED trial showing a significant risk reduction in a low-risk population. Contrary to the pharmacological approach of cardiovascular prevention, the adoption of the Mediterranean diet has been associated with a significant reduction in new cancers and overall mortality. Thus, in terms of evidence-based medicine, the full adoption of a modern version of the Mediterranean diet pattern can be considered one of the most effective approaches for the prevention of fatal and nonfatal CVD complications.

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Current dietary investigations have found unsaturated fatty acids such as oleic and linoleic acid and dietary nitrate to be concentrated in the traditional Mediterranean diet, a diet with beneficial effects on the development of CVD and its risk factors.
“Current dietary investigations have found these fatty acids and dietary nitrate to be concentrated in the traditional Mediterranean diet, a diet with beneficial effects on the development of CVD and its risk factors[362,375–377].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [362]

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Authors: de Lorgeril, M.
Venue: Current Atherosclerosis Reports
Publisher: Springer Science and Business Media LLC
Published: 2013-10-09
Volume: 15
Issue: 12
Pages: 370-370
ISSN: 1523-3804 (ISSN-L)
1534-6242
DOI: 10.1007/s11883-013-0370-4
OpenAlex: W2083403483
Cited by: 60
References: 39
Citations by year: 2025: 4 · 2024: 1 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 2 · 2015: 9 · 2014: 12 · 2012: 1
FWCI: 1.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Atherosclerosis Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: Mediterranean diet, cardiovascular disease, cardiovascular disease prevention, PREDIMED trial, Mediterranean diet adherence, Mediterranean diet score, dietary intervention, mortality reduction, cancer risk reduction
MeSH terms: Animals, Cardiovascular Diseases, Clinical Trials as Topic, Humans, Risk Factors, Incidence, Evidence-Based Medicine, Diet, Mediterranean

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Mediterranean diet and cardiovascular disease: historical perspective and latest evidence

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