Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women
Open accessAbstract
BACKGROUND: Several studies have documented an inverse association between adherence to the Mediterranean diet and risk of coronary heart disease (CHD), but few data are available on the relationship between Mediterranean diet and risk of stroke. METHODS AND RESULTS: For the present study, 74,886 women 38 to 63 years of age in the Nurses' Health Study, a cohort study of female nurses, without a history of cardiovascular disease and diabetes were followed up from 1984 to 2004. We computed an Alternate Mediterranean Diet Score from self-reported dietary data collected through validated food frequency questionnaires administered 6 times between 1984 and 2002. Relative risks for incident CHD, stroke, and combined fatal cardiovascular disease were estimated with Cox proportional-hazards models adjusted for cardiovascular risk factors. During 20 years of follow-up, 2391 incident cases of CHD, 1763 incident cases of stroke, and 1077 cardiovascular disease deaths (fatal CHD and strokes combined) were ascertained. Women in the top Alternate Mediterranean Diet Score quintile were at lower risk for both CHD and stroke compared with those in the bottom quintile (relative risk [RR], 0.71; 95% CI, 0.62 to 0.82; P for trend<0.0001 for CHD; RR, 0.87; 95% CI, 0.73 to 1.02; P for trend=0.03 for stroke). Cardiovascular disease mortality was significantly lower among women in the top quintile of the Alternate Mediterranean Diet Score (RR, 0.61; 95% CI, 0.49 to 0.76; P for trend<0.0001). CONCLUSIONS: A greater adherence to the Mediterranean diet, as reflected by a higher Alternate Mediterranean Diet Score, was associated with a lower risk of incident CHD and stroke in women.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several population-based and prospective epidemiological studies have shown that adherence to the Mediterranean diet might have a protective effect against cardiovascular disease, stroke, obesity, diabetes, hypertension, several types of cancers, allergic diseases, and Alzheimer and Parkinson's disease.
“Several population-based and prospective epidemiological studies have shown that adherence to the Mediterranean diet might have a protective effect against cardiovascular disease, stroke, obesity, diabetes, hypertension, several type of cancers, allergic diseases and, most recently, Alzheimer and Parkinson’s disease (7–18).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [7]
Similar evidence has been collected for non-fatal cardiovascular disease.
“Subsequently, similar evidences have been collected for 'non-fatal' CVD.[3][4][5]”
From Cohort Profile: Design and methods of the PREDIMED study (2012) · cites this paper as [3]
Both the Health Professionals Follow-up Study and the Nurses' Health Study find a ≈20% increased CHD risk in the highest category of SSB consumption compared with the lowest category.
“Both the HPFS and the NHS find a ≈20% increased CHD risk in the highest category of SSB consumption compared with the lowest category (132,133);”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [133]
A Mediterranean diet including nuts lowers CVD risk in observational studies and RCTs.
“In observational studies (133,217–220) and RCTs (164,221–223) a Mediterranean diet including nuts lowers CVD risk.”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [133]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Compendium of physical activities: an update of activity codes and MET intensities
AINSWORTH, B. E., HASKELL, W. L., WHITT, M. C., IRWIN, M. L., SWARTZ, A. M., STRATH, S. J., O???BRIEN, W. L., BASSETT, D. R., SCHMITZ, K. H., EMPLAINCOURT, P. O., et al. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00009 · Cited by 8,497 · see citing works
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981 · see citing works
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903 · see citing works
Willett, W. C. (1998) · doi:10.1093/acprof:oso/9780195122978.001.0001 · Cited by 4,541 · see citing works
Self-citationAdherence to a Mediterranean diet and survival in a Greek population
Trichopoulou, A., Costacou, T., Bamia, C., & Trichopoulos, D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025039 · Cited by 4,397 · see citing works
Cardiovascular Survey Methods.
Rose, G., & Blackburn, H. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-6-1335_2 · Cited by 3,065 · see citing works
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910 · see citing works
Mediterranean diet pyramid: a cultural model for healthy eating
Willett, W., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A., Helsing, E., & Trichopoulos, D. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1402s · Cited by 2,461 · see citing works
Self-citationWeight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Shai, I., Schwarzfuchs, D., Henkin, Y., Shahar, D. R., Witkow, S., Greenberg, I., Golan, R., Fraser, D., Bolotin, A., Vardi, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708681 · Cited by 2,143 · see citing works
Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D'Armiento, M., D'Andrea, F., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.292.12.1440 · Cited by 2,126 · see citing works
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
de Lorgeril, M., Renaud, S., Salen, P., Monjaud, I., Mamelle, N., Martin, J. L., Guidollet, J., Touboul, P., & Delaye, J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92580-1 · Cited by 2,122 · see citing works
Fish Intake, Contaminants, and Human Health: Evaluating the Risks and the Benefits
Mozaffarian, D., & Rimm, E. B. (2006) · JAMA · doi:10.1001/jama.296.15.1885 · Cited by 1,966 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors: A Randomized Trial
Estruch, R., Martínez-González, M. Á., Corella, D., Salas-Salvadó, J., Ruiz-Gutiérrez, V., Covas, M. I., Fiol, M., Gómez-Gracia, E., López-Sabater, M. C., Vinyoles, E., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-1-200607040-00004 · Cited by 1,704 · see citing works
Adherence to a DASH-Style Diet and Risk of Coronary Heart Disease and Stroke in Women
Fung, T. T. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.7.713 · Cited by 1,567 · see citing works
Self-citationMcCullough, M. L., Feskanich, D., Stampfer, M. J., Giovannucci, E. L., Rimm, E. B., Hu, F. B., Spiegelman, D., Hunter, D. J., Colditz, G. A., & Willett, W. C. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1261 · Cited by 1,191 · see citing works
Self-citationHu, F. B., Stampfer, M. J., Rimm, E., Ascherio, A., Rosner, B. A., Spiegelman, D., & Willett, W. C. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009849 · Cited by 1,085 · see citing works
Self-citationSalvini, S., Hunter, D. J., SAMPSON, L., Stampfer, M. J., Colditz, G. A., ROSNER, B. A., & Willett, W. C. (1989) · International Journal of Epidemiology · doi:10.1093/ije/18.4.858 · Cited by 1,038 · see citing works
Self-citationDiet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction
Fung, T. T., McCullough, M. L., Newby, P., Manson, J. E., Meigs, J. B., Rifai, N., Willett, W. C., & Hu, F. B. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.1.163 · Cited by 1,001 · see citing works
Self-citationCOLDITZ, G. A., MARTIN, P., STAMPFER, M. J., WILLETT, W. C., SAMPSON, L., ROSNER, B., HENNEKENS, C. H., & SPEIZER, F. E. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114319 · Cited by 992 · see citing works
Self-citationHe, K., Song, Y., Daviglus, M. L., Liu, K., Van Horn, L., Dyer, A. R., & Greenland, P. (2004) · Circulation · doi:10.1161/01.cir.0000132503.19410.6b · Cited by 764 · see citing works
Mitrou, P. N. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.22.2461 · Cited by 574 · see citing works
Ψαλτοπούλου, Θ., Naska, A., Orfanos, P., Trichopoulos, D., Mountokalakis, T. D., & Trichopoulou, A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1012 · Cited by 517 · see citing works
Oh, K. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi085 · Cited by 498 · see citing works
The National Survey of Stroke. Clinical findings.
Walker, A., Robins, M., & Weinfeld, F. D. (1981) · PubMed · Cited by 460 · see citing works
Effect of a Traditional Mediterranean Diet on Lipoprotein Oxidation: A Randomized Controlled Trial
Fitó, M., Guxens, M., Corella, D., Sáez, G., Estruch, R., de la Torre, R., Francés, F., Cabezas, C., López-Sabater, M. D. C., Marrugat, J., et al. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1195 · Cited by 448 · see citing works
Pitsavos, C., Panagiotakos, D. B., Tzima, N., Chrysohoou, C. A., Economou, M., Zampelas, A., & Stefanadis, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.82.3.694 · Cited by 283 · see citing works
Pitsavos, C., Panagiotakos, D. B., Tzima, N., et al. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.694 · Cited by 240 · see citing works
Mantzoros, C. S., Williams, C. J., Manson, J. E., Meigs, J. B., & Hu, F. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.328 · Cited by 213 · see citing works
Self-citationResch, K. (2008) · PubMed · Cited by 203 · see citing works
Mantzoros, C. S., Williams, C. J., Manson, J. E., Meigs, J. B., & Hu, F. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.328 · Cited by 180 · see citing works
Self-citationKnoops, K. T. B., de Groot, L. C. P. G. M., Kromhout, D., Perrin, A.-E., Moreiras-Varela, O., Menotti, A., & van Staveren, W. A. (2004) · JAMA · doi:10.1001/jama.292.12.1433 · Cited by 146 · see citing works
Dietary glycemic load and atherothrombotic risk
Liu, S., & Willett, W. C. (2002) · Current Atherosclerosis Reports · doi:10.1007/s11883-002-0050-2 · Cited by 146 · see citing works
Self-citationDai, J., Miller, A. H., Bremner, J. D., Goldberg, J., Jones, L., Shallenberger, L., Buckham, R., Murrah, N. V., Veledar, E., Wilson, P. W., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.710699 · Cited by 145 · see citing works
Levitan, E. B., Mittleman, M. A., Håkansson, N., & Wolk, A. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1521 · Cited by 100 · see citing works
Sinovas, C. R. (2007) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/s0214-9168(07)74173-6 · Cited by 85 · see citing works
Serrano-Martínez, M., Palacios, M., Martínez-Losa, E., Lezaún, R., Maraví, C., Prado, M., Martínez, J. A., & Martínez‐González, M. Á. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0532-9 · Cited by 78 · see citing works
Nutrition, Lipids, and Cardiovascular Disease
Kuller, L. H. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00230.x · Cited by 60 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [19]Fung TT McCullough ML Newby PK Manson JE Meigs JB Rifai N Willett WC Hu FB Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction American Journal of Clinical Nutrition 2005 82 163 173 16002815
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596 · see citing works
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700 · see citing works
Heart Disease and Stroke Statistics—2014 Update
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · Circulation · doi:10.1161/01.cir.0000441139.02102.80 · Cited by 5,207 · see citing works
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292 · see citing works
O'Donnell, M. J., Xavier, D., Liu, L., Zhang, H., Chin, S. L., Rao-Melacini, P., Rangarajan, S., Islam, S., Pais, P., McQueen, M. J., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60834-3 · Cited by 3,448 · see citing works
Global diets link environmental sustainability and human health
Tilman, D. G., & Clark, M. (2014) · Nature · doi:10.1038/nature13959 · Cited by 3,413 · see citing works
Sofi, F., Abbate, R., Gensini, G. F., & Casini, A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29673 · Cited by 1,605 · see citing works
Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines
Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works
Definition of the Mediterranean Diet; A Literature Review
Davis, C. R., Bryan, J., Hodgson, J. M., & Murphy, K. J. (2015) · Nutrients · doi:10.3390/nu7115459 · Cited by 1,184 · see citing works
Sofi, F., Macchi, C., Abbate, R., Gensini, G. F., & Casini, A. (2014) · Public Health Nutrition · doi:10.1017/s1368980013003169 · Cited by 997 · see citing works
The Mediterranean Diet, its Components, and Cardiovascular Disease
Widmer, R. J., Flammer, A. J., Lerman, L. O., & Lerman, A. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.10.014 · Cited by 963 · see citing works
“Observational and ecological studies such as the original Seven Countries Study have shown positive benefits of the Mediterranean diet in terms of cardioprotection, surrogate markers for cardiovascular disease, as well as overall morbidity and mortality.(27,28) Subsequently, a large meta-analysis of over 50,000 patien…”
BackgroundThe Mediterranean diet and health: a comprehensive overview
Guasch‐Ferré, M., & Willett, W. C. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13333 · Cited by 940 · see citing works
Self-citationThe Mediterranean Diet and Cardiovascular Health: A Critical Review
Martínez-González, M. A., Gea, A., & Ruiz-Canela, M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313348 · Cited by 878 · see citing works
Mediterranean diet, stroke, cognitive impairment, and depression: A meta‐analysis
Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., Sergentanis, I. N., Kosti, R., & Scarmeas, N. (2013) · Annals of Neurology · doi:10.1002/ana.23944 · Cited by 793 · see citing works
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms
Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762 · see citing works
Cohort Profile: Design and methods of the PREDIMED study
Martinez-Gonzalez, M. A., Corella, D., Salas-Salvado, J., Ros, E., Covas, M. I., Fiol, M., Warnberg, J., Aros, F., Ruiz-Gutierrez, V., Lamuela-Raventos, R. M., et al. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyq250 · Cited by 671 · see citing works
Epidemiology and Genetics of Sudden Cardiac Death
Deo, R., & Albert, C. (2012) · Circulation · doi:10.1161/circulationaha.111.023838 · Cited by 616 · see citing works
Fuster, V., & Kelly, B. B. (2010) · Cited by 611 · see citing works
Components of a Cardioprotective Diet: New Insights
Mozaffarian, D., Appel, L. J., & Van Horn, L. (2011) · Circulation · doi:10.1161/circulationaha.110.968735 · Cited by 571 · see citing works
Shams‐White, M., Pannucci, T. E., Lerman, J., Herrick, K., Zimmer, M. C., Mathieu, K. M., Stoody, E. E., & Reedy, J. (2023) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2023.05.015 · Cited by 525 · see citing works
Anand, S. S., Hawkes, C., de Souza, R. J., Mente, A., Dehghan, M., Nugent, R., Zulyniak, M. A., Weis, T., Bernstein, A. M., Krauss, R. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.050 · Cited by 507 · see citing works
“Both the HPFS and the NHS find an approximate 20% increased CHD risk in the highest category of SSB consumption compared with the lowest category (132,133); and, after adjusting for dietary and nondietary cardiovascular risk factors, a 16% increased stroke risk (134).”
BackgroundSelf-citationRosato, V., Temple, N. J., La Vecchia, C., Castellan, G., Tavani, A., & Guercio, V. (2019) · European Journal of Nutrition · doi:10.1007/s00394-017-1582-0 · Cited by 479 · see citing works
Micha, R., Shulkin, M., Peñalvo, J. L., Khatibzadeh, S., Singh, G. M., Rao, M., Fahimi, S., Powles, J. W., & Mozaffarian, D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175149 · Cited by 477 · see citing works
Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil
Cicerale, S., Lucas, L., & Keast, R. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.09.006 · Cited by 467 · see citing works
Association of changes in diet quality with total and cause-specific mortality
Sotos-Prieto, M., Bhupathiraju, S. N., Mattei, J., Fung, T. T., Li, Y., Pan, A., Willett, W. C., Rimm, E. B., & Hu, F. B. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1613502 · Cited by 466 · see citing works
Self-citationGrosso, G., Marventano, S., Yang, J., Micek, A., Pajak, A., Scalfi, L., Galvano, F., & Kales, S. N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1107021 · Cited by 456 · see citing works
Biological Activities of Phenolic Compounds Present in Virgin Olive Oil
Cicerale, S., Lucas, L., & Keast, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11020458 · Cited by 449 · see citing works
Horn, L. V., Carson, J. A. S., Appel, L. J., Burke, L. E., Economos, C. D., Karmally, W., Lancaster, K. J., Lichtenstein, A. H., Johnson, R. K., Thomas, R. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000462 · Cited by 431 · see citing works
Nutritional and health benefits of pulses
Mudryj, A. N., Yu, N., & Aukema, H. M. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0557 · Cited by 424 · see citing works
Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease
Shan, Z., Li, Y., Baden, M. Y., Bhupathiraju, S. N., Wang, D. D., Sun, Q., Rexrode, K. M., Rimm, E. B., Qi, L., Willett, W. C., et al. (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.2176 · Cited by 448 · see citing works
Self-citationAdherence to a Mediterranean-type dietary pattern and cognitive decline in a community population
Tangney, C. C., Kwasny, M. J., Li, H., Wilson, R. S., Evans, D. A., & Morris, M. C. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007369 · Cited by 397 · see citing works
Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease
Rees, K., Takeda, A., Martin, N., Ellis, L., Wijesekara, D., Vepa, A., Das, A., Hartley, L., & Stranges, S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009825.pub3 · Cited by 395 · see citing works
Diet, Stress and Mental Health
Bremner, J. D., Moazzami, K., Wittbrodt, M. T., Nye, J. A., Lima, B. B., Gillespie, C. F., Rapaport, M. H., Pearce, B. D., Shah, A. J., & Vaccarino, V. (2020) · Nutrients · doi:10.3390/nu12082428 · Cited by 394 · see citing works
The Mediterranean diet, plasma metabolome, and cardiovascular disease risk
Li, J., Guasch‐Ferré, M., Chung, W., Ruiz‐Canela, M., Toledo, E., Corella, D., Bhupathiraju, S. N., Tobias, D. K., Tabung, F. K., Hu, J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa209 · Cited by 364 · see citing works
Self-citationMediterranean diet and nonalcoholic fatty liver disease
Anania, C., Perla, F. M., Olivero, F., Pacifico, L., & Chiesa, C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i19.2083 · Cited by 353 · see citing works
Buckland, G., Gonzalez, C. A., Agudo, A., Vilardell, M., Berenguer, A., Amiano, P., Ardanaz, E., Arriola, L., Barricarte, A., Basterretxea, M., et al. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp282 · Cited by 344 · see citing works
Grundy, S. M. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.10.001 · Cited by 349 · see citing works
Zhong, V. W., Van Horn, L., Cornelis, M. C., Wilkins, J. T., Ning, H., Carnethon, M. R., Greenland, P., Mentz, R. J., Tucker, K. L., Zhao, L., et al. (2019) · JAMA · doi:10.1001/jama.2019.1572 · Cited by 327 · see citing works
Wang, D. D., Toledo, E., Hruby, A., Rosner, B. A., Willett, W. C., Sun, Q., Razquin, C., Zheng, Y., Ruiz-Canela, M., Guasch-Ferré, M., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024261 · Cited by 327 · see citing works
Self-citationGrundy, S. M., Arai, H., Barter, P. J., Bersot, T. P., Betteridge, D. J., Carmena, R., Cuevas, A. M., Davidson, M. H., Genest, J. J., Kesäniemi, Y. A., et al. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.12.005 · Cited by 328 · see citing works
The mutual interplay of gut microbiota, diet and human disease
Illiano, P., Brambilla, R., & Parolini, C. (2020) · FEBS Journal · doi:10.1111/febs.15217 · Cited by 331 · see citing works
Harmon, B. E., Boushey, C. J., Shvetsov, Y. B., Ettienne, R., Reedy, J., Wilkens, L. R., Le Marchand, L., Henderson, B. E., & Kolonel, L. N. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.090688 · Cited by 364 · see citing works
A review of statistical methods for dietary pattern analysis
Zhao, J., Li, Z., Gao, Q., Zhao, H., Chen, S., Huang, L., Wang, W., & Wang, T. (2021) · Nutrition Journal · doi:10.1186/s12937-021-00692-7 · Cited by 325 · see citing works
Medina‐Remón, A., Kirwan, R., Lamuela-Raventós, R. M., & Estruch, R. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1158690 · Cited by 317 · see citing works
Martínez‐González, M. Á., Hershey, M. S., Zazpe, I., & Trichopoulou, A. (2017) · Nutrients · doi:10.3390/nu9111226 · Cited by 313 · see citing works
Nordmann, A. J., Suter, K., Bucher, H. C., Shai, I., Tuttle, K. R., Estruch, R., & Briel, M. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.04.024 · Cited by 304 · see citing works
The Mediterranean Diet: From an Environment-Driven Food Culture to an Emerging Medical Prescription
Lăcătușu, C.-M., Grigorescu, E.-D., Floria, M., Onofriescu, A., & Mihai, B. M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16060942 · Cited by 308 · see citing works
Mediterranean dietary pattern and cancer risk in the EPIC cohort
Couto, E., Boffetta, P., Lagiou, P., Ferrari, P., Buckland, G., Overvad, K., Dahm, C. C., Tjønneland, A., Olsen, A., Clavel-Chapelon, F., et al. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.106 · Cited by 291 · see citing works
Kirkpatrick, S. I., Reedy, J., Krebs‐Smith, S. M., Pannucci, T. E., Subar, A. F., Wilson, M. M., Lerman, J., & Tooze, J. A. (2018) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2018.05.020 · Cited by 290 · see citing works
Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial
Ruiz‐Canela, M., Toledo, E., Clish, C. B., Hruby, A., Liang, L., Salas‐Salvadó, J., Razquín, C., Corella, D., Estruch, R., Ros, E., et al. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2015.251710 · Cited by 288 · see citing works
Self-citationFruit Polyphenols: A Review of Anti-inflammatory Effects in Humans
Joseph, S. V., Edirisinghe, I., & Burton‐Freeman, B. M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.767221 · Cited by 282 · see citing works
Lin, J., Fung, T. T., Hu, F. B., & Curhan, G. C. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.09.027 · Cited by 270 · see citing works
Self-citationMediterranean diet and telomere length in Nurses' Health Study: population based cohort study
Crous‐Bou, M., Fung, T. T., Prescott, J., Julin, B., Du, M., Sun, Q., Rexrode, K. M., Hu, F. B., & Vivo, I. D. (2014) · BMJ · doi:10.1136/bmj.g6674 · Cited by 270 · see citing works
Self-citationPalomeras, E., & Ruiz, V. C. (2010) · Current Cardiology Reviews · doi:10.2174/157340310791658785 · Cited by 264 · see citing works
Uusitupa, M. I. J., Hermansen, K., Savolainen, M. J., Schwab, U., Kolehmainen, M., Brader, L., Mortensen, L. S., Cloetens, L., Johansson‐Persson, A., Önning, G., et al. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12044 · Cited by 267 · see citing works
Fruits and Vegetables Consumption and Risk of Stroke: A Meta-Analysis of Prospective Cohort Studies
Hu, D., Huang, J., Wang, Y., Zhang, D., & Qu, Y. (2014) · Stroke · doi:10.1161/strokeaha.114.004836 · Cited by 258 · see citing works
The Case for Diet: A Safe and Efficacious Strategy for Secondary Stroke Prevention
Dearborn, J. L., Urrutia, V., & Kernan, W. N. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00001 · Cited by 255 · see citing works
Diet-Quality Scores and the Risk of Type 2 Diabetes in Men
de Koning, L., Chiuve, S. E., Fung, T. T., Willett, W. C., Rimm, E. B., & Hu, F. B. (2011) · Diabetes Care · doi:10.2337/dc10-2352 · Cited by 252 · see citing works
Self-citationThe Secrets of the Mediterranean Diet. Does [Only] Olive Oil Matter?
Mazzocchi, A., Leone, L., Agostoni, C., & Pali-Schöll, I. (2019) · Nutrients · doi:10.3390/nu11122941 · Cited by 252 · see citing works
'Mediterranean' dietary pattern for the primary prevention of cardiovascular disease
Rees, K., Hartley, L., Flowers, N., Clarke, A., Hooper, L., Thorogood, M., & Stranges, S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009825.pub2 · Cited by 243 · see citing works
Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study
García‐Arellano, A., Ramallal, R., Ruiz‐Canela, M., Salas‐Salvadó, J., Corella, D., Shivappa, N., Schröder, H., Hébert, J. R., Ros, E., Gómez‐Gracia, E., et al. (2015) · Nutrients · doi:10.3390/nu7064124 · Cited by 242 · see citing works
Berries: Anti-inflammatory Effects in Humans
Joseph, S. V., Edirisinghe, I., & Burton‐Freeman, B. M. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4044056 · Cited by 240 · see citing works
Gardener, H. E., Wright, C. B., Gu, Y., Demmer, R. T., Boden-Albala, B. M., Elkind, M. S. V., Sacco, R. L., & Scarmeas, N. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.012799 · Cited by 237 · see citing works
Zuo, K., Li, J., Li, K., Hu, C., Gao, Y., Chen, M., Hu, R., Liu, Y., Chi, H., Wang, H., et al. (2019) · GigaScience · doi:10.1093/gigascience/giz058 · Cited by 235 · see citing works
Benefits of the Mediterranean diet: Epidemiological and molecular aspects
Serra‐Majem, L., Román‐Viñas, B., Sánchez‐Villegas, A., Guasch‐Ferré, M., Corella, D., & Vecchia, C. L. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.001 · Cited by 240 · see citing works
Healthy Aspects of the Nordic Diet Are Related to Lower Total Mortality,
Olsen, A., Egeberg, R., Halkjær, J., Christensen, J., Overvad, K., & Tjønneland, A. M. (2011) · Journal of Nutrition · doi:10.3945/jn.110.131375 · Cited by 231 · see citing works
Prepregnancy adherence to dietary patterns and lower risk of gestational diabetes mellitus
Tobias, D. K., Zhang, C., Chavarro, J. E., Bowers, K. A., Rich-Edwards, J. W., ROSNER, B. A., Mozaffarian, D., & Hu, F. B. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.028266 · Cited by 223 · see citing works
Self-citationCoronary heart disease prevention: Nutrients, foods, and dietary patterns
Bhupathiraju, S. N., & Tucker, K. L. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.04.038 · Cited by 224 · see citing works
Agnoli, C., Krogh, V., Grioni, S., Sieri, S., Palli, D., Masala, G., Sacerdote, C., Vineis, P., Tumino, R., Frasca, G., et al. (2011) · The Journal of Nutrition · doi:10.3945/jn.111.140061 · Cited by 218 · see citing works
Pirinccioglu, A. G., Gökalp, D., Pirinççioğlu, M., Kızıl, G., & Kızıl, M. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.07.022 · Cited by 221 · see citing works
van den Brandt, P. A., & Schulpen, M. (2017) · International Journal of Cancer · doi:10.1002/ijc.30654 · Cited by 221 · see citing works
Associations of Diet with Albuminuria and Kidney Function Decline
Lin, J., Hu, F. B., & Curhan, G. C. (2010) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08001109 · Cited by 216 · see citing works
Self-citationTektonidis, T. G., Åkesson, A., Gigante, B., Wolk, A., & Larsson, S. C. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.039 · Cited by 216 · see citing works
Changes in Diet Quality Scores and Risk of Cardiovascular Disease Among US Men and Women
Sotos‐Prieto, M., Bhupathiraju, S. N., Mattei, J., Fung, T. T., Li, Y., Pan, A., Willett, W. C., Rimm, E. B., & Hu, F. B. (2015) · Circulation · doi:10.1161/circulationaha.115.017158 · Cited by 221 · see citing works
Self-citationSofi, F., Macchi, C., Abbate, R., Gensini, G. F., & Casini, A. (2013) · BioFactors · doi:10.1002/biof.1096 · Cited by 219 · see citing works
Galbete, C., Schwingshackl, L., Schwedhelm, C., Boeing, H., & Schulze, M. B. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0427-3 · Cited by 212 · see citing works
Mediterranean diet and the incidence of cardiovascular disease: A Spanish cohort
Martínez‐González, M. Á., García–López, M., Bes‐Rastrollo, M., Toledo, E., Martínez‐Lapiscina, E. H., Delgado‐Rodríguez, M., Ruiz, Z. V., Benito, S., & Beunza, J. J. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.10.005 · Cited by 213 · see citing works
The Effects of the Mediterranean Diet on Health and Gut Microbiota
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2023) · Nutrients · doi:10.3390/nu15092150 · Cited by 213 · see citing works
Mediterranean Diet Reduces 24-Hour Ambulatory Blood Pressure, Blood Glucose, and Lipids
Doménech, M., Román, P., Lapetra, J., de la Corte, F. J. G., Sala‐Vila, A., de la Torre, R., Corella, D., Salas‐Salvadó, J., Ruíz-Gutiérrez, V., Lamuela-Raventós, R. M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.03353 · Cited by 212 · see citing works
Dietary Flavonoids and Risk of Stroke in Women
Cassidy, A., Rimm, E. B., O’Reilly, É. J., Logroscino, G., Kay, C. D., Chiuve, S. E., & Rexrode, K. M. (2012) · Stroke · doi:10.1161/strokeaha.111.637835 · Cited by 210 · see citing works
Self-citationDiet quality is associated with disability and symptom severity in multiple sclerosis
Fitzgerald, K. C., Tyry, T. M., Salter, A. R., Cofield, S. S., Cutter, G., Fox, R. J., & Marrie, R. A. (2017) · Neurology · doi:10.1212/wnl.0000000000004768 · Cited by 208 · see citing works
Adherence to a Low-Risk, Healthy Lifestyle and Risk of Sudden Cardiac Death Among Women
Chiuve, S. E., Fung, T. T., Rexrode, K. M., Spiegelman, D. L., Manson, J. E., Stampfer, M. J., & Albert, C. M. (2011) · JAMA · doi:10.1001/jama.2011.907 · Cited by 199 · see citing works
Self-citationExamining Plausibility of Self-Reported Energy Intake Data: Considerations for Method Selection
Banna, J. C., McCrory, M. A., Fialkowski, M. K., & Boushey, C. J. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00045 · Cited by 200 · see citing works
Mediterranean and DASH Diet Scores and Mortality in Women With Heart Failure
Levitan, E. B., Lewis, C. E., Tinker, L. F., Eaton, C. B., Ahmed, A., Manson, J. E., Snetselaar, L. G., Martin, L. W., Trevisan, M., Howard, B. V., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000495 · Cited by 200 · see citing works
Self-citationHealth Benefits of Mediterranean Diet
Martini, D. (2019) · Nutrients · doi:10.3390/nu11081802 · Cited by 200 · see citing works
Forsyth, C., Kouvari, M., D'Cunha, N. M., Georgousopoulou, E. N., Panagiotakos, D. B., Mellor, D. D., Kellett, J., & Naumovski, N. (2017) · Rheumatology International · doi:10.1007/s00296-017-3912-1 · Cited by 196 · see citing works
Lopez-Garcia, E., Rodriguez-Artalejo, F., Li, T. Y., Fung, T. T., Li, S., Willett, W. C., Rimm, E. B., & Hu, F. B. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.068106 · Cited by 190 · see citing works
Self-citationMa, J., Hennein, R., Liu, C., Long, M. T., Hoffmann, U., Jacques, P. F., Lichtenstein, A. H., Hu, F. B., & Levy, D. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.03.038 · Cited by 187 · see citing works
Self-citationThe Mediterranean Diet: An Update of the Clinical Trials
Finicelli, M., Salle, A. D., Galderisi, U., & Peluso, G. (2022) · Nutrients · doi:10.3390/nu14142956 · Cited by 194 · see citing works
Global Improvement in Dietary Quality Could Lead to Substantial Reduction in Premature Death
Wang, D. D., Li, Y., Afshin, A., Springmann, M., Mozaffarian, D., Stampfer, M. J., Hu, F. B., Murray, C. J. L., & Willett, W. C. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz010 · Cited by 184 · see citing works
Self-citationHardman, R. J., Kennedy, G., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00022 · Cited by 179 · see citing works
Mediterranean diet and life expectancy; beyond olive oil, fruits, and vegetables
Martínez‐González, M. Á., & Martín‐Calvo, N. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000316 · Cited by 177 · see citing works
Cabanillas, B., Jappe, U., & Novak, N. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700446 · Cited by 177 · see citing works
- Authors
- Fung, T. T., Rexrode, K. M., Mantzoros, C. S., Manson, J. E., Willett, W. C., & Hu, F. B.
- Affiliations
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Circulation
- Published
- 2009-03-03
- Volume
- 119
- Issue
- 8
- Pages
- 1093-1100
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC2724471
- OpenAlex
- W2015746229
- Cited by
- 916
- References
- 37
- Citations by year
- 2026: 43 · 2025: 63 · 2024: 58 · 2023: 59 · 2022: 47 · 2021: 59 · 2020: 68 · 2019: 47 · 2018: 56 · 2017: 46 · 2016: 51 · 2015: 59 · 2014: 54 · 2013: 49 · 2012: 48
- FWCI
- 52.19
- Type
- journal article
- Language
- en
- Update notices
- correction (2009-03-31)
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL60712, R01HL060712, HL88521, HL34594, R01HL034594, R01HL088521)
- National Cancer Institute (CA-87969, P01CA087969)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK040561)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- Mediterranean diet, coronary artery disease, stroke, cardiovascular mortality, women, dietary adherence, alternate Mediterranean diet score, Nurses' Health Study, diet and cardiovascular risk
- MeSH terms
- Adult, Coronary Disease, Female, Follow-Up Studies, Humans, Middle Aged, Risk Factors, Cohort Studies, Incidence, Stroke, Diet, Mediterranean
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
