Inflammation: The Common Pathway of Stress-Related Diseases
Open accessAbstract
While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.
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Stress is physiologically costly leading to a greater propensity for disease.
“Since stress is physiologically costly leading to a greater propensity for disease (e.g., Liu et al. 2017; Everly and Lating 2019), it”
From Unlimited Associative Learning and the origins of consciousness: a primer and some predictions (2020) · cites this paper as Liu et al. 2017
The Introduction says severe or prolonged stress increases the risk of physical and psychiatric disorders, supporting the disease-risk part of the claim. It also says an appropriate short-term stress response is protective and beneficial, so the source does not support the unqualified implication that stress is always physiologically costly. (LLM, conf=0.85)
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- Authors
- Liu, Y.-Z., Wang, Y.-X., & Jiang, C.-L.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Jiang, Chun-Lei
- ORCID
- Jiang, Chun-Lei
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2017-06-20
- Volume
- 11
- Pages
- 316-316
- ISSN
- 1662-5161 (ISSN-L)
- PMC
- PMC5476783
- OpenAlex
- W2656568860
- Cited by
- 800
- References
- 118
- Citations by year
- 2026: 82 · 2025: 103 · 2024: 146 · 2023: 123 · 2022: 90 · 2021: 88 · 2020: 82 · 2019: 61 · 2018: 22 · 2017: 2
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Human Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81571169, 31371200)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- chronic stress, inflammation, stress-related disorders, homeostasis, atherosclerosis, non-alcoholic fatty liver disease, depression, stress system, disease prevention and treatment
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