The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response
Open accessAbstract
Purpose of Review Coronavirus disease of 2019 (COVID-19) is a cause of significant morbidity and mortality worldwide. While cardiac injury has been demonstrated in critically ill COVID-19 patients, the mechanism of injury remains unclear. Here, we review our current knowledge of the biology of SARS-CoV-2 and the potential mechanisms of myocardial injury due to viral toxicities and host immune responses. Recent Findings A number of studies have reported an epidemiological association between history of cardiac disease and worsened outcome during COVID infection. Development of new onset myocardial injury during COVID-19 also increases mortality. While limited data exist, potential mechanisms of cardiac injury include direct viral entry through the angiotensin-converting enzyme 2 (ACE2) receptor and toxicity in host cells, hypoxia-related myocyte injury, and immune-mediated cytokine release syndrome. Potential treatments for reducing viral infection and excessive immune responses are also discussed. Summary COVID patients with cardiac disease history or acquire new cardiac injury are at an increased risk for in-hospital morbidity and mortality. More studies are needed to address the mechanism of cardiotoxicity and the treatments that can minimize permanent damage to the cardiovascular system.
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An interactive web-based dashboard to track COVID-19 in real time
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Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China
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Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China
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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
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COVID-19 and the cardiovascular system
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Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
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Cited by
Zhao, Y.-M., Shang, Y.-M., Song, W.-B., Li, Q.-Q., Xie, H., Xu, Q.-F., Jia, J.-L., Li, L.-M., Mao, H.-L., Zhou, X.-M., et al. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100463 · Cited by 927
Aboudounya, M. M., & Heads, R. J. (2021) · Mediators of Inflammation · doi:10.1155/2021/8874339 · Cited by 346
Grimaud, M., Starck, J., Levy, M., Marais, C., Chareyre, J., Khraiche, D., Leruez-Ville, M., Quartier, P., Léger, P. L., Geslain, G., et al. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00690-8 · Cited by 319
Multiple organ dysfunction in SARS-CoV-2: MODS-CoV-2
Robba, C., Battaglini, D., Pelosi, P., & Rocco, P. R. M. (2020) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2020.1778470 · Cited by 268
Perez-Bermejo, J. A., Kang, S., Rockwood, S. J., Simoneau, C. R., Joy, D. A., Silva, A. C., Ramadoss, G. N., Flanigan, W. R., Fozouni, P., Li, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf7872 · Cited by 259
Metadata
- Authors
- Zhu, H., Rhee, J.-W., Cheng, P., Waliany, S., Chang, A., Witteles, R. M., Maecker, H., Davis, M. M., Nguyen, P. K., & Wu, S. M.
- Venue
- Current Cardiology Reports
- Published
- 2020-04-21
- Volume
- 22
- Issue
- 5
- Pages
- 32-32
- ISSN
- 1523-3782 (ISSN-L)
- 1534-3170
- OpenAlex
- W3016514446
- Cited by
- 210
- References
- 19
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhu, H., Rhee, J.-W., Cheng, P., Waliany, S., Chang, A., Witteles, R. M., Maecker, H., Davis, M. M., Nguyen, P. K., & Wu, S. M. (2020). Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response. Current Cardiology Reports. https://doi.org/10.1007/s11886-020-01292-3
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