Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 319

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children

Open access
Grimaud, Marion, Starck, Julie, Levy, Michael, Marais, Clémence, Chareyre, Judith, Khraiche, Diala, Leruez-Ville, Marianne, Quartier, Pierre, Léger, Pierre Louis, Geslain, Guillaume, Semaan, Nada, Moulin, Florence, Bendavid, Matthieu, Jean, Sandrine, Poncelet, Géraldine, Renolleau, Sylvain, Oualha, Mehdi·2020·Annals of Intensive Care
DOI 10.1186/s13613-020-00690-8
Open this paper in CoChat — free account

Abstract

Background: A recent increase in children admitted with hypotensive shock and fever in the context of the COVID-19 outbreak requires an urgent characterization and assessment of the involvement of SARS-CoV-2 infection. This is a case series performed at 4 academic tertiary care centers in Paris of all the children admitted to the pediatric intensive care unit (PICU) with shock, fever and suspected SARS-CoV-2 infection between April 15th and April 27th, 2020. Results: 20 critically ill children admitted for shock had an acute myocarditis (left ventricular ejection fraction, 35% (25–55); troponin, 269 ng/mL (31–4607)), and arterial hypotension with mainly vasoplegic clinical presentation. The first symptoms before PICU admission were intense abdominal pain and fever for 6 days (1–10). All children had highly elevated C-reactive protein (> 94 mg/L) and procalcitonin (> 1.6 ng/mL) without microbial cause. At least one feature of Kawasaki disease was found in all children (fever, n = 20, skin rash, n = 10; conjunctivitis, n = 6; cheilitis, n = 5; adenitis, n = 2), but none had the typical form. SARS-CoV-2 PCR and serology were positive for 10 and 15 children, respectively. One child had both negative SARS-CoV-2 PCR and serology, but had a typical SARS-CoV-2 chest tomography scan. All children but one needed an inotropic/vasoactive drug support (epinephrine, n = 12; milrinone, n = 10; dobutamine, n = 6, norepinephrine, n = 4) and 8 were intubated. All children received intravenous immunoglobulin (2 g per kilogram) with adjuvant corticosteroids ( n = 2), IL 1 receptor antagonist ( n = 1) or a monoclonal antibody against IL-6 receptor ( n = 1). All children survived and were afebrile with a full left ventricular function recovery at PICU discharge. Conclusions: Acute myocarditis with intense systemic inflammation and atypical Kawasaki disease is an emerging severe pediatric disease following SARS-CoV-2 infection. Early recognition of this disease is needed and referral to an expert center is recommended. A delayed and inappropriate host immunological response is suspected. While underlying mechanisms remain unclear, further investigations are required to target an optimal treatment.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s13613-020-00690-8

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 16 references

Cited by

See all 319

Metadata

Authors
Grimaud, M., Starck, J., Levy, M., Marais, C., Chareyre, J., Khraiche, D., Leruez-Ville, M., Quartier, P., Léger, P. L., Geslain, G., Semaan, N., Moulin, F., Bendavid, M., Jean, S., Poncelet, G., Renolleau, S., & Oualha, M.
Venue
Annals of Intensive Care
Publisher
Elsevier BV
Published
2020-06-01
Volume
10
Issue
1
Pages
69-69
ISSN
2110-5820 (ISSN-L)
DOI
10.1186/s13613-020-00690-8
OpenAlex
W3031924236
Cited by
319
References
16
FWCI
61.61
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. https://app.cochat.ai/papers/10.1186/s13613-020-00690-8
The paper
Grimaud, M., Starck, J., Levy, M., Marais, C., Chareyre, J., Khraiche, D., Leruez-Ville, M., Quartier, P., Léger, P. L., Geslain, G., Semaan, N., Moulin, F., Bendavid, M., Jean, S., Poncelet, G., Renolleau, S., & Oualha, M. (2020). Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Annals of Intensive Care. https://doi.org/10.1186/s13613-020-00690-8

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.