Treating diabetes and prediabetes by focusing on obesity management
Open accessAbstract
Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes mellitus (T2DM). In obesity, the adipose cell releases nonesterified free fatty acids, hormones, adipocytokines, and other substances that are involved in insulin resistance. Under normal conditions, the pancreatic islet beta cells increase production of insulin sufficiently to maintain normal blood glucose concentrations despite insulin resistance. However, in genetically predisposed patients, the beta cells eventually become dysfunctional and T2DM develops. The development of T2DM can be delayed or sometimes prevented in individuals with obesity who are able to lose weight. Weight loss can be achieved medically with behavioral therapies that combine diet and exercise treatment or with behavioral therapies combined with weight-loss medications or weight-loss surgery. In this article, we summarize the evidence of obesity management in treating T2DM and prediabetes.
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Weight loss has been shown to decrease insulin resistance in both obese T2D patients and obese T2D-free individuals, suggesting that insulin resistance is related to increased nutrient storage.
“Weight loss has been shown to decrease insulin resistance in both obese T2D patients and obese T2D-free individuals, suggesting that insulin resistance is related to increased nutrient storage.117”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [117]
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- [30]Norris SL Zhang X Avenell A Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta-analysis Arch Intern Med 2004 164 1395 1404 15249348
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- Authors
- Khaodhiar, L., Cummings, S., & Apovian, C. M.
- Affiliations
- Boston University (US)
- Corresponding author
- Apovian, Caroline M.
- ORCID
- Apovian, Caroline M.
- Venue
- Current Diabetes Reports
- Published
- 2009-09-29
- Volume
- 9
- Issue
- 5
- Pages
- 348-354
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- PMC
- PMC2857968
- OpenAlex
- W2152912717
- Cited by
- 56
- References
- 60
- Citations by year
- 2025: 4 · 2024: 3 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK046200)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Keywords
- obesity treatment, type 2 diabetes, prediabetes, insulin resistance, beta-cell dysfunction, weight loss, behavior therapy, diet and exercise, anti-obesity drugs, bariatric surgery, adipose tissue hormones, free fatty acids
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Obesity, Prediabetic State, Weight Loss, Anti-Obesity Agents
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